Year of Graduation: 2019
Research Lab: Professor Alexander Leggy Arnold
Major Area of Focus: Organic Chemistry/Medicinal Chemistry

Thesis: Part I: An Investigation of Calcitroic Acid and Its Phase II Conjugates. Part II: Toward the Development of a Novel Orally-available Asthma Treatment Targeting Gabaa Receptors in the Lungs

Publications

1. Olivia B. Yu, Tania R. Mutchie, Elliot S. Di Milo and Leggy A. Arnold, “Synthesis and biological evaluation of calcioic acid” Steroids 2020, 154, 108536.
2. Tania R. Mutchie, Olivia B. Yu, Elliot S. Di Milo, and Leggy A. Arnold "Alternative binding sites at the vitamin D receptor and their ligands" Molecular and Cellular Endocrinology 2019, 485, 1-8.
3. Gloria S. Forkuo, Amanda N. Nieman, Revathi Kodali, Nicolas M. Zahn, Guanguan Li, M. S. Rashid Roni, Michael Rajesh Stephen, Ted W. Harris, Rajwana Jahan, Margaret L. Guthrie, Olivia B. Yu, Janet L. Fisher, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook , and Leggy A. Arnold “A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA(A) Receptors in the Lung” Molecular Pharmaceutics 2018, 15, 1766-1777.
4. Gloria S. Forkuo, Amanda N. Nieman, Nina Y. Yuan, Revathi Kodali, Olivia B. Yu, Nicolas M. Zahn, Rajwana Jahan, Guanguan Li, Michael Rajesh Stephen, Margaret L. Guthrie, Michael M. Poe, Benjamin D. Hartzler, Ted W. Harris, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook and Leggy A. Arnold “Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators” Molecular Pharmaceutics 2017. 14, 2088-2098.
5. Rajwana Jahan, Michael R. Stephen, Gloria S. Forkuo, Revathi Kodali, Margaret L. Guthrie, Amanda N. Nieman, Nina Y. Yuan, Nicolas M. Zahn, Michael M. Poe, Guanguan Li, Olivia B. Yu, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford, James M. Cook, and Leggy A. Arnold "Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments" European Journal of Medicinal Chemistry 2017, 126, 550-560.
6. Olivia B. Yu, Leggy A. Arnold, “Calcitroic acid–a review” ACS Chemical Biology 2016, 11, 2665-2672.
7. Gloria S. Forkuo, Margaret L. Guthrie, Nina Y. Yuan, Amanda N. Nieman, Revathi Kodali, Rajwana Jahan, Michael R. Stephen, Gene T. Yocum, Marco Treven, Michael M. Poe, Guanguan Li, Olivia B. Yu, Benjamin D. Hartzler, Nicolas M. Zahn, Margot Ernst, Charles W. Emala, Douglas C. Stafford, James M. Cook, and Leggy A. Arnold “Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments” Molecular Pharmaceutics 2016, 13, 2026-2038.
8. Kelly A. Teske, Olivia B. Yu, and Leggy A. Arnold, “Inhibitors for the Vitamin D Receptor–Coregulator Interaction” Vitamin and Hormones 2016, 100, 45-82.
9. Kelly A. Teske, Jonathon W. Bogart, Luis M. Sanchez, Olivia B. Yu, Joshua V. Preston, James M. Cook, Nicholas R. Silvaggi, Daniel D. Bikle, and Leggy A. Arnold, “Synthesis and Evaluation of Vitamin D Receptor-Mediated Activities of Cholesterol and Vitamin D Metabolites European Journal of Medicinal Chemistry 2016, 109, 238-246.