Year of Graduation: 2019
Research Lab: Professor Alexander Leggy Arnold
Major Area of Focus: Biochemistry

Thesis: Targeting the gamma Aminobutyric Acid a Receptor (GABAAR) to Alleviate Inflammation for Asthma and Neuropathic Pain

Publications

1. Guanguan Li, Amanda N. Nieman, Md Yeunus Mian, Nicolas M. Zahn, Brandon N. Mikulsky, Michael M. Poe, Kashi R. Methuku, Yongfeng Liu, James M. Cook, Douglas C. Stafford, and Leggy A. Arnold “A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA_A Receptor” Molecules 2020.
2. Amanda N. Nieman, Guanguan Li, Nicolas M. Zahn, Md Yeunus Mian, Brandon N. Mikulsky, Dylan A. Hoffman, Taylor M. Wilcox, Alexander S. Kehoe, Ian W. Luecke, Michael M. Poe, David Alvarez-Carbonell, James M. Cook, Douglas C. Stafford, and Leggy A. Arnold “Targeting Nitric Oxide Production in Microglia with Novel Imidazodiazepines for Nonsedative Pain Treatment” ACS Chemical Neuroscience 2020, 11(13), 2019-2030.
3. Gloria S. Forkuo, Amanda N. Nieman, Revathi Kodali, Nicolas M. Zahn, Guanguan Li, M. S. Rashid Roni, Michael Rajesh Stephen, Ted W. Harris, Rajwana Jahan, Margaret L. Guthrie, Olivia B. Yu, Janet L. Fisher, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook , and Leggy A. Arnold “A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA(A) Receptors in the Lung” Molecular Pharmaceutics 2018, 15, 1766-1777.
4. Gloria S. Forkuo, Amanda N. Nieman, Nina Y. Yuan, Revathi Kodali, Olivia B. Yu, Nicolas M. Zahn, Rajwana Jahan, Guanguan Li, Michael Rajesh Stephen, Margaret L. Guthrie, Michael M. Poe, Benjamin D. Hartzler, Ted W. Harris, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook and Leggy A. Arnold “Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators” Molecular Pharmaceutics 2017. 14, 2088-2098.
5. Rajwana Jahan, Michael R. Stephen, Gloria S. Forkuo, Revathi Kodali, Margaret L. Guthrie, Amanda N. Nieman, Nina Y. Yuan, Nicolas M. Zahn, Michael M. Poe, Guanguan Li, Olivia B. Yu, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford, James M. Cook, and Leggy A. Arnold "Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments" European Journal of Medicinal Chemistry 2017, 126, 550-560.
6. Gloria S. Forkuo, Margaret L. Guthrie, Nina Y. Yuan, Amanda N. Nieman, Revathi Kodali, Rajwana Jahan, Michael R. Stephen, Gene T. Yocum, Marco Treven, Michael M. Poe, Guanguan Li, Olivia B. Yu, Benjamin D. Hartzler, Nicolas M. Zahn, Margot Ernst, Charles W. Emala, Douglas C. Stafford, James M. Cook, and Leggy A. Arnold “Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments” Molecular Pharmaceutics 2016, 13, 2026-2038.