Mian, Md Yeunus

Chemistry & Biochemistry

Research Lab: Cook Research Group

Research Advisor: Dr. James M Cook

Major Area of Focus: Medicinal Chemistry & Organic Synthesis
Minor Area of Focus: Biochemistry

Thesis: Design and synthesis of  chiral and non-chiral benzodiazepines and imidazodiazepines  as α–subtype selective GABAAR modulators to treat schistosomiasis, pain, epilepsy, asthma as well as mental disorder


 Bachelor of Pharmacy, 2006-2010, University of Dhaka

Master of Pharmacy (Pharmaceutical Chemistry)


Why I like Chemistry

I love chemistry because it helps me to understand the world around me

Why I chose the Chemistry and Biochemistry Program at UW-Milwaukee

Outstanding faculty and excellent research helped me to choose chemistry program in UW-Milwaukee.

Favorite things to do in Milwaukee

 Biking, Fishing, Festivals, Shows, Restaurants etc



  1. A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor. Guanguan Li , Amanda N. Nieman, Md Yeunus Mian , Nicolas M. Zahn, Brandon N. Mikulsky, Michael M. Poe, Kashi R. Methuku, Yongfeng Liu, James M. Cook, Douglas C. Stafford  and Leggy A. Arnold Molecules 2020, 25, 3864
  2. The Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects. Daniel E Knutson, Jodi L Smith, Xingjie Ping, Xiaoming Jin, Lalit K Golani, Guanguan Li, VVN Phani Babu Tiruveedhula, Farjana Rashid, Md Yeunus Mian, Rajwana Jahan, Dishary Sharmin, Rok Cerne, James M Cook, Jeffrey M Witkin. ACS Chem. Neurosci. 2020, 11, 2624−2637
  3. Improved Scale-up Synthesis and Purification of Clinical Asthma Candidate MIDD0301. Daniel E. Knutson, M. S. Rashid Roni, Md Yeunus Mian, James M. Cook, Douglas C. Stafford, Leggy A. Arnold. Process Res. Dev. 2020, 24, 1467−1476
  4. The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development. J.M. Witkin. A. Biggerstaff, B. Kivella, J.L. Smith , Md Y. Mian , L.K. Golani , F. Rashid , D. Sharmin , D.E. Knutson , R. Cerne , J.M. Cook. Pharmacology, Biochemistry and Behavior 2020, 196, 172996
  5. Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment. Amanda N Nieman, Guanguan Li, Nicolas M Zahn, Md Yeunus Mian, Brandon N Mikulsky, Dylan A Hoffman, Taylor M Wilcox, Alexander S Kehoe, Ian W Luecke, Michael M Poe, David Alvarez-Carbonell, James M Cook, Douglas C Stafford, Leggy A Arnold. ACS Chem. Neurosci. 2020, 11, 2019−2030
  6. The effects of pH on the structure and bioavailability of imidazobenzodiazepine -3-carboxylate MIDD0301. MS Rashid Roni, Guanguan Li, Brandon N Mikulsky, Daniel E Knutson, Md Yeunus Mian, Nicolas M Zahn, James M Cook, Douglas C Stafford, Leggy A  Arnold. Molecular Pharmaceutics 2020, 17, 1182−1192
  7. Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. Paul McCusker, Md Yeunus Mian, Guanguan Li, Michael D Olp, VVN Phani Babu Tiruveedhula, Farjana Rashid, Lalit Kumar Golani, Ranjit S Verma, Brian C Smith, James M Cook, John D Chan. PLoS Negl Trop Dis. 2019;13(11):e0007826.
  8. In vitro thrombolytic activity, antioxidant and cytotoxic properties of fruit extracts of Ficus erecta (Thunb.) Abullah Al Faysal, Md Yeunus Mian, Muhammed Mahfuzur Rahman,* Mofiza Akter, Mahfuzur Rahman, Tariqul Haque Tuhin, and Marzia Bilkiss. Journal of Medicinal Plants Research. 2018, 12(4), 50-54,
  9. Preparation of Microcrystalline Cellulose from Cotton and its Evaluation as Direct Compressible Excipient in the Formulation of Naproxen Tablets. Md Nurul Islam Setu, Md Yeunus Mian, Nur Jaharat Lubna, Abu Asad Chowdhury. Dhaka Univ. J. Pharm. Sci. 2014, 13(2): 187-192
  10. EVALUATION OF ANTIMICROBIAL ACTIVITIES OF SOME BANGLADESHI MEDICINAL PLANTS. Tasnuva Sharmin, Sharmin Reza Chowdhury, Yeunus Mian*, Masbahul Hoque, Md. Sumsujjaman, and Faijun Nahar. World J Pharm Sci 2014; 2(2): 170-175
  11. Investigation of biological activities of Allamanda blanchetii, the violet Allamanda. Tasnuva Sharmin, Probir Kumar Sarker, Farhana Islam, Sharmin Reza Chowdhury, Tasdique Mohammad Quadery, Md Yeunus Mian, SM Ashikur Rahman, Zahid Sadek Chowdhury, Md Sharif Ullah.. Journal of Pharmacy Research. 2013,6, 761-764
  12. Analgesic and Anti-diarrheal Activities of Aganosma dichotoma (Roth) K. Schum. in Swiss-Albino Mice Model. Md. Al Faruk, Mohammad Firoz Khan, Yeunus Mian, Mohammad Sharifur Rahman and Mohammad A. Rashid. Bangladesh Pharmaceutical Journal .2015, 18(1): 15-19
  13. Antioxidant and antimicrobial activities of flower and bark extract of Swietenia mahagoni (L.) Jacq. M. Ashikur Rahman, Maksuda Akter, Tasnuva Easmin Hira, Md.Yeunus Mian, Iftekhar Ahmed, Muhammed Mahfuzur Rahman. Journal of Pharmacognosy and Phytochemistry 2014; 2 (6): 185-188
  14. Effects of Solvent Polarity on Solvation Free Energy, Dipole Moment, Polarizability, Hyperpolarizability and Molecular Properties of Metronidazole. Mohammad Firoz Khan, Ridwan Bin Rashid, Md Yeunus Mian, Mohammad S Rahman, Mohammad A Rashid. Bangladesh Pharmaceutical Journal. 2016, 19(1): 9-14
  15. Cytotoxic, Thrombolytic And Membrane Stabilizing Activities Of Swietenia Mahagoni (L.) Jacq. Bark Extract. Maksuda Akter, Tasnuva Easmin Hira, Md Yeunus Mian, Iftekhar Ahmed, Muhammed Mahfuzur Rahman, SM Ashikur Rahman. Journal of SUB. 2014, 5(1): 32-38
  16. Evaluation of cardiovascular activities of an ayurvedic preparation 'khadirarishta' in rat model. Mohammad Shah Amran* Md. Musfaqur Rahman Sajjad, Md. Taimuzzaman Sharif, Kaniz Nahar Deepa, Kamrun Nahar, Most. Shammi Rahman, Yeunus Mian, Nur Jaharat Lubna, Asma Rahman, Md. Zakir Sultan, Shaila Kabir, Abu Asad Chowdhury. ejpmr, 2015,2(2), 223-234
  17. Cytotoxic, thrombolytic, antioxidant and antimicrobial activities of Cocos nucifera endocarp extracts. Md. Al-Aslam Kanon Iftekhar Ahmed, Abdullah Al Faysal, Md. Yeunus Mian, S. M. Ashikur Rahman, Muhammed Mahfuzur Rahman. World J Pharm Sci 2015; 3(6): 1072-1075
  18. Evaluation of membrane stabilizing, cytotoxic and anti-diarrheal activities of leaves of Calotropis Gigantea BR. Rabeya Moni Muhammed Mahfuzur Rahman*, Md. Yeunus Mian, Abdullah Al Faysal , S. M. Ashikur Rahman , Ridwan Islam. World J Pharm Sci 2015; 3(12): 2364-2367
  19. An in vitro study on the complexation of phenoxymethyl penicillin potassium and phenytoin. Sagar Kumar Paul,Md. Zakir Sultan, Shotabdi Sikder, Sangita Paul Kundu, Shampa Kundu, Asma Rahman, Yeunus Mian, Md. Sarwar Hossain, Nur Jaharat Lubna, Md. Shah Amran. Journal of Medicinal Chemistry and Drug Discovery. 2014, 5, 33-42



Teaching Assistant Award Laboratory 2020