Year of Graduation: 2013
Research Lab: Professor Alexander Leggy Arnold
Major Area of Focus: Analytical Chemistry/High throughput screening

Thesis: High-Throughput Approaches for the Assessment of Factors Influencing Bioavailability of Small Molecules in Pre-Clinical Drug Development

Publications:

1. Preetpal S. Sidhu, Nicholas Nassif, Megan M. McCallum, Kelly A. Teske, Belaynesh Feleke, Nina Y. Yuan, Premchendar Nandhikonda, James M. Cook, Rakesh K. Singh, Daniel D. Bikle, Leggy A. Arnold “Vitamin D Receptor-Coactivator Binding Inhibitors” ACS Medicinal Chemistry Letters 2014, 5(2), 199-204.
2. Megan M. McCallum, Alan J. Pawlak, William R. Shadrick, Anton Simeonov, Ajit Jadhav, Adam Yasgar, David J. Maloney, Leggy A. Arnold “A Fluorescence-Based High Throughput Assay for the Determination of Small Molecule-Human Serum Albumin Protein Binding” Anal Bioanal Chem 2014, 406(7), 1867-1875.
3. Premchendar Nandhikonda, Adam Yasgar, Athena M. Baranowski, Preetpal S. Sidhu, Megan M. McCallum, Alan J. Pawlak, Kelly A. Teske, Belaynesh Feleke, Nina Y. Yuan, Chinedum Kevin, Daniel D. Bikle, Steven D. Ayers, Paul Webb, Ganesha Rai, Anton Simeonov, Ajit Jadhav, David Maloney, Leggy A. Arnold “PPARδ agonist GW0742 interacts weakly with multiple nuclear receptors including the vitamin D receptor” Biochemistry 2013, 52, 4193-4203.
4. Megan M. McCallum, Premchendar Nandhikonda, Jonathan J. Temmer, Charles Eyermann, Anton Simeonov, Ajit Jadhav, Adam Yasgar, David Maloney, Leggy A. Arnold ” High-Throughput Identification of Promiscuous Inhibitors from Screening Libraries with the Use of a Thiol-Containing Fluorescent Probe” Journal of Biomolecular Screening 2013, 18(6), 705-713.
5. Premchendar Nandhikonda, Wen Z. Lynt, Megan M. McCallum, Tahniyath Ara, Athena M. Baranowski, Nina Y. Yuan, Dana Pearson, Daniel D. Bikle, R. Kiplin Guy, Leggy A. Arnold “Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators” Journal of Medicinal Chemistry 2012, 55(10), 4640-4651.
6. Laurent Brard, Thilo S. Lange, Katina Robison, Kyu Kwang Kim, Tahniyath Ara, Megan Marie McCallum, Leggy A. Arnold, Richard G. Moore, Rakesh K. Singh “Evaluation of the first Ergocalciferol-derived, non hypercalcemic anti-cancer agent MT19c in ovarian cancer SKOV-3 cell lines” Gynecologic Oncology, 2011, 123(2), 370-8.