Lalit Golani's CV

Education:

Ph.D. (2010-2016): Medicinal Chemistry, Duquesne University, Pittsburgh, PA, USA

Master of Pharmacy (2004-2006): Medicinal Chemistry, Manipal University, Karnataka, India

Bachelor of Pharmacy (1999-2003): Guru Gobind Singh Indraprastha University, Delhi, India

Research Lab:

Prof. James M Cook

Research Areas:

Medicinal Chemistry, Organic Chemistry, Drug Design, Molecular Modeling

Selected Publications:

Golani, L. K.; Platt, D. M.; Rüedi-Bettschen, D.; Edwanker, C.; Huang, S.; Poe, M. M.; Furtmüller, R.; Sieghart, W.; Cook, J. M.; Rowlett, J. K., 8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor. Frontiers in Pharmacology 2021, 12 (528). https://doi.org/10.3389/fphar.2021.625233

Pandey, K. P.; Khan, Z. A.; Golani, L. K.; Mondal, P.; Mian, Y.; Rashid, F.; Tiruveedhula, V.; Knutson, D. E.; Sharmin, D.; Ahmed, T.; Rezvanian, S.; Zahn, N. M.; Arnold, L. A.; Witkin, J. M.; Cook, J. M., Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands. Arkivoc 2020, 2020 (Pt 7), 242-256. (Shared first author) https://doi.org/10.24820/ark.5550190.p011.398

Witkin, J. M.; Li, G.; Golani, L. K.; Xiong, W.; Smith, J. L.; Ping, X.; Rashid, F.; Jahan, R.; Cerne, R.; Cook, J. M.; Jin, X., The Positive Allosteric Modulator of α 2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury. J Pharmacol Exp Ther 2020, 372 (1), 83-94. https://doi.org/10.1124/jpet.119.260968

Golani, L. K.; Wallace-Povirk, A.; Deis, S. M.; Wong, J.; Ke, J.; Gu, X.; Raghavan, S.; Wilson, M. R.; Li, X.; Polin, L.; de Waal, P. W.; White, K.; Kushner, J.; O'Connor, C.; Hou, Z.; Xu, H. E.; Melcher, K.; Dann, C. E., 3rd; Matherly, L. H.; Gangjee, A., Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 2016, 59 (17), 7856-76. https://doi.org/10.1021/acs.jmedchem.6b00594

Golani, L. K.; George, C.; Zhao, S.; Raghavan, S.; Orr, S.; Wallace, A.; Wilson, M. R.; Hou, Z.; Matherly, L. H.; Gangjee, A., Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors alpha and beta and the proton-coupled folate transporter. J Med Chem 2014, 57 (19), 8152-66. https://doi.org/10.1021/jm501113m

Kumar, L.; Kaushik, N.; Malik, A.; Kumar, P., Synthesis of Admantane Substituted Spiro 1,2,4-TrioxanesUsing Simple and Cheap Starting Material. Asian Journal of Chemistry 2009, 21 (5), 3540-3546. http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=21_5_30