Nitrophorins are nitric oxide transporting proteins utilized by the blood sucking insect Rhodnius prolixus. What's unique about these proteins, is they work in tandem with histamines to not only mask their feeding, but also utilize the unique biological characteristic that... Read More
Acid Ceramidase Inhibitors: A De Novo Drug Target and a New Class of Drug for Glioblastoma Glioblastoma remains the most common malignant cancer of the central nervous system with an overall survival <1.5 years. Therapeutically resistant glioblastoma or glioblastoma stem-like... Read More
Photocatalysis is the process where the rate of a photoreaction is altered by the presence of a substance that is not itself consumed in the reaction. Photocatalysis can be heterogeneous or homogeneous, with the majority of the research up-to-date focused... Read More
“Determining the impact of protein-protein interactions on Transglutaminase 2 activity” Tonya N. Zeczycki, PhD Assistant Professor Department of Biochemistry and Molecular Biology and the East Carolina Diabetes and Obesity Institute East Carolina Heart Institute Host: Nicholas R. Silvaggi ABSTRACT In... Read More
NADPH oxidase (Nox) isoforms are a family of enzymes that generate superoxide and hydrogen peroxide as primary oxidants during the activation of oxygen. Nox isoforms play a key role in immunity, infection, and inflammation. Yet, to date there are no... Read More
Abstract: Diffuse large B-cell lymphomas (DLBCLs) are life-threatening cancers that are the most common form of non-Hodgkin’s lymphomas. The current standard treatment of DLBCL involves the RCHOP regimen. However many patients treated with those therapies relapse. The transcriptional repressor BCL6... Read More