Natural Product Synthesis

Yoshito Kishi

Department of Chemistry and Chemical Biology, Harvard University

After a brief review on acyclic stereocontrol and convergent synthesis, we shall discuss the current status on catalytic asymmetric Ni/Cr-mediated coupling reactions, with the focus on a unified, efficient, scalable total synthesis of the halichondrin class of marine natural products. At the end of presentation, we shall give our perspective on a complex natural product synthesis.