Web Site: www.uwmlarsonlab.org
Ph.D., University of Wisconsin-Madison, 2003
My laboratory, the Affective Neuroscience Laboratory, is dedicated to understanding the neural bases of healthy and pathological emotional processing. Currently, my research program has two main foci: individual differences in emotional processing which confer risk for psychopathology, particularly anxiety or depression, and characterizing the nature of stimuli in the environment which serve as signals for different types of emotions. I use neuroimaging, psychophysiological, behavioral, and self-report tools to examine affective processing broadly, including the time course, intensity, and regulation of affective responses. As such, my work sits at the intersection of emotion, psychopathology, and neuroscience research.
Current research questions include:
- Can the time course of affective response usefully index individual differences related to risk and resilience for psychopathology?
- Are symptoms of anxiety and depression associated with prolonged experience of negative affect? What are the neural correlates of this phenomenon?
- Are some forms of anxiety associated with rapid onset of fear? Can this be identified at the level of the brain?
- What, if anything, distinguishes worry and rumination? Are there separable neural instantiations of these two processes?
- Can visual signals of threat and happiness be reduced to fundamental underlying properties, such as their underlying geometry? Do brain regions implicated in recognition and experience of threat and happiness respond to simple geometric shapes?
Psych 412: Psychopathology
Psych 611: The Science of Human Emotions
Psych 912: Developmental Psychopathology
Lotfi, S., Ward, R. T., Ayazi, M., Bennett, K. P., Larson, C. L., & Lee, H. (2020). The Effects of Emotional Working Memory Training on Worry Symptoms and Error-Related Negativity of Individuals with High Trait Anxiety: A Randomized Controlled Study. COGNITIVE THERAPY AND RESEARCH
Huggins, A. A., Harvey, A. M., Miskovich, T. A., Lee, H. J., & Larson, C. L. (2020). Resting-state functional connectivity of supplementary motor area associated with skin-picking symptom severity. JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS
Weis, C., Belleau, E. L., Pedersen, W. S., Miskovich, T. A., & Larson, C. L. (2018). Structural connectivity of the posterior cingulum is related to re-experiencing symptoms in PTSD. Chronic Stress, 2, 1-9.
Belleau, E. L., Pedersen, W. S., Miskovich, T. A., Helmstetter, F. J., & Larson, C. L. (2018). Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
Pedersen, W. S., Balderston, N. L., Miskovich, T. A., Belleau, E. L., Helmstetter, F. J., & Larson, C. L. (2017). Disentangling the effects of stimulus novelty and affective valence in the amygdala, hippocampus, and bed nucleus of the stria terminalis. Social, Cognitive, and Affective Neuroscience., 12(5), 748-757.
Stout, D. M., Shackman, A. J., Pedersen, W. S., Miskovich, T. A., & Larson, C. L. (2017). Neural circuitry governing anxious individuals' mis-allocation of working memory to threat. SCIENTIFIC REPORTS
Stout, D., Shackman, A. J., Johnson, J., & Larson, C. L. (2015). Worry is associated with impaired gating of threat from working memory. Emotion, 15, 6-11.
Belleau, E., Taubitz, L. E., & Larson, C. L. (2015). Imbalance of default mode and regulatory networks during externally-focused processing in depression. Social, Cognitive, & Affective Neuroscience, 10(5), 744-751.
Stout, D. M., Shackman, A. J., & Larson, C. L. (2013). Failure to filter: Anxious individuals show inefficient gating of threat from working memory. Frontiers in Human Neuroscience, 7.
Larson, C. L., Baskin-Sommers, A. R., Stout, D. M., Balderston, N. L., Schultz, D. H., Curtin, J. J., Kiehl, K. A., & Newman, J. P. (2013). The interplay of attention and emotion: Top-down attention modulates amygdala activation in psychopathy. Cognitive, Affective, & Behavioral Neuroscience, 13, 757-770.
Larson, C. L., Aronoff, J., Sarinopoulos, I. C., & Zhu, D. C. (2009). Recognizing threat: Simple geometric shapes activate neural circuitry underlying threat detection. Journal of Cognitive Neuroscience, 21, 1523-1535.
Larson, C. L., Aronoff, J., Stearns, J., & (2007). The shape of threat: Simple geometric forms evoke rapid and sustained capture of attention. Emotion, 7, 526-534.
Larson, C. L., Schaefer, H. S., Siegle, G. J., Cory, J. A., Anderle, M. J., & Davidson, R. J. (2006). Fear is fast in phobic individuals: Amygdala activation in response to fear-relevant stimuli. Biological Psychiatry, 60, 410-417.
Davidson, R. J., Putnam, K. M., Larson, C. L., , & (2000). Dysfunction in the neural circuitry of emotion regulation—A possible prelude to violence. Science, 289, 591-594.