The broad focus of the Udvadia lab is on cellular programming that governs nervous system development and regeneration. More specifically, we use fish and rodent models to understand how dynamic changes in transcription factor activity, chromatin accessibility and chromatin architecture govern:
Andrea Rau, Sumona P. Dhara, Ava J. Udvadia, Paul L. Auer, 2019. Regeneration Rosetta: an interactive web application to explore regeneration-associated gene expression and chromatin accessibility. G3, doi: 10.1534/g3.119.400729.
Sumona P. Dhara, Andrea Rau, Michael J. Lister, Nicole M. Recka, Michael D. Laiosa, Paul L. Auer, Ava J. Udvadia, 2019. Cellular reprogramming for successful CNS axon regeneration is driven by a temporally changing cast of transcription factors. Scientific Reports, doi: 10.1038/s41598-019-50485-6.
Seema Das, Virinchipuram S. Sreevidya, Ava J. Udvadia, Gyaneshwar Prasad, 2019. Dopamine-induced sulfatase and its regulator are required for Salmonella enterica serovar Typhimurium pathogenesis. Microbiology 165: 302-310.
Maria R. Replogle, Virinchipuram S. Sreevidya, Vivian M. Lee, Michael D. Laiosa, Kurt R. Svoboda, Ava J. Udvadia, 2018. Establishment of a Murine culture system for modeling the temporal progression of cranial and trunk neural crest cell differentiation. Disease Models & Mechanisms, doi: 10.1242/dmm.035097.
Ryan R. Williams, Ishwariya Venkatesh, Damien D. Pearse, Ava J. Udvadia, and Mary Bartlett Bunge, 2015. MASH1/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNS. PLOS One 103: e0118918. (Conceptualization: 50%; Experiments: 5%; Analysis: 50%; Writing: 25%; Ishwariya Venkatesh earned her PhD in my lab)
Evdokia Menelaou, Ava J. Udvadia, Robert L. Tanguay, and Kurt R. Svoboda, 2014. Activation of α2A-containing nicotinic acetylcholine receptors mediates nicotine-induced motor output in embryonic zebrafish. European Journal of Neuroscience 40: 2225-2240.
Kerry N. Veth, Jason R. Willer, Ross F. Collery, Matthew P. Gray, Gregory B. Willer, Daniel S. Wagner, Mary C. Mullins, Ava J. Udvadia, Richard S. Smith, Simon W.M. John, Ronald G. Gregg, Brian A. Link, 2011. Mutations in zebrafish lrp2 result in adult onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLOS Genetics 7: e1001310.
Dena R. Hammond and Ava J. Udvadia, 2010. Cabin1 expression suggests roles in neuronal development. Developmental Dynamics 239: 2443–2451.
Brandon W. Kusik, Dena R. Hammond, and Ava J. Udvadia, 2010. Transcriptional regulatory regions of gap43 needed in developing and regenerating retinal ganglion cells. Developmental Dynamics 239: 482-495.
Angela Schmoldt, Jennifer Forecki, Dena R. Hammond, and Ava J. Udvadia, 2009. Exploring differential gene expression in zebrafish to teach basic molecular biology skills. Zebrafish 6:187-199.
Ava J. Udvadia, 2008. 3.6 kb genomic sequence from Takifugu capable of promoting axon growth associated gene expression in developing and regenerating zebrafish neurons. Gene Expression Patterns 8: 382-388.
Brandon W. Kusik, Michael J. Carvan III, Ava J. Udvadia, 2008. Detection of mercury in aquatic environments using EPRE reporter zebrafish. Marine Biotechnology, 10: 750-757.
Daniel N. Weber, Victoria Connaughton, John Dellinger, David Klemer, Ava Udvadia, Michael J. Carvan III, 2008. Selenomethionine reduces visual deficits due to developmental methylmercury exposures. Physiology and Behavior 93 (1), p.250-260.
J. Rudi Strickler, Ava J. Udvadia, John Marino, Nick Radabaugh, Josh Ziarek, and Ai Nihongi, 2005. Visibility as a Factor in the Copepod - Planktivorous Fish Relationship. Scientia Marina, 69 (Supp. 1) 111-124.
Elwood Linney and Ava J. Udvadia, 2004. Construction and detection of fluorescent germ-line transgenic zebrafish. Methods in Molecular Biology 254: 271-288.
Ava J. Udvadia and Elwood Linney, 2003. Windows into Development: Historic, Current and Future Perspectives on Transgenic Zebrafish. Developmental Biology, 256: 1-17.
Ava J. Udvadia, Reinhard W. Köster, and J. H. Pate Skene, 2001. GAP-43 Promoter Elements in Transgenic Zebrafish Reveal a Difference in Signals for Axon Growth During CNS Development and Regeneration. Development, 128: 1175-1182.