Dr. Madhusudan Day hosts speaker, UWM Biological Sciences graduate student Leena Sathe. Leena will present a talk entitled ‘Mechanisms of Translational Silencing of Yeast HAC1 mRNA’. The presentation will begin at 4:00 pm in Lapham Hall N101. Please join us for refreshments outside the lecture hall starting at 3:30 pm.

Abstract:

The budding yeast (Saccharomyces cerevisiae) HAC1 gene encodes a transcription factor that mitigates cellular stress by activating a suite of genes. Transcriptome profiling reveals that yeast expresses two isoforms of HAC1 mRNA: HAC1a and HAC1b, both remain translationally silent. Our results show that HAC1a remains translationally silent due to inefficient loading of ribosome on the mRNA whereas HAC1b represents a long non-coding mRNA. In my talk, I will discuss the mechanisms of translational silencing of HAC1 mRNA.