The Laboratory for Compound Safety and focuses on the evaluation of materials, molecules, and biologicals in respect to safety and is managed by veterinarian Dr. Allen and directed by Dr. Arnold.
The Laboratory collaborates with UWM researchers and researchers from other institutes and companies and carries out safety studies for non-compliant research (non-GLP). Research involving animals is regulated by UWM’s Animal Care Program (ACP), which assures the humane care and use of animals by students, staff, and faculty. The ACP is AAALAC accredited (certification no. 001225) and strictly complies with all elements of an institutional program in the care and use of animals as described by the “Guide for the Care and Use of Laboratory Animals” (National Research Council). The center has approved IACUC protocols in place to conduct studies listed below.
- Microsomal stability study (phase I) (dog, rat, mouse, human)
- Microsomal stability study (phase II glucuronidation and glucosidation) (mouse, rat, human, mouse)
- Pharmacokinetic study in mice or rats (oral or other and IV)
- Escalating dose toxicity study (mouse and rat) (oral or other)
- 14-Days repeated-dose toxicity study (mouse and rat) (oral or other)
- AMES Test
- In Vitro Micronucleus test (CHL/IU Cells)
- In Vivo Micronucleus Assay (mouse or rat) (three doses, one harvest)
Our team is trained to identify adverse effects based on clinical scoring. In addition to histology, we offer many tests that are not limited to pulmonary toxicity using plethysmography, cardiotoxicity by measuring blood pressure and ECG, and CNS effect by measuring sensorimotor activities by rotarod and open field tests. We are also offering standard urinalysis and hematolysis.
Identification of metabolites is also part our service. Sometimes, adverse effects are mediated by metabolites rather than the lead compound. Our medicinal chemistry team can offer advise to reduce unwanted metabolism.
Want to be part of the UWM experience? UWM is offering incubator and vivarium space at a reasonable price. Renting space at a university is often preferred due to the existing support structure, access to instrumentation and collaborative project.