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Peter Schwander

Associate Professor
Physics
 (414) 229-1166
 KEN 3188

Research

Professor Schwander’s research focuses on the structure and function of biological macromolecules by analyzing snapshots obtained by x-rays and electron microscopy.

He is also a participant in BioXFEL, a Science and Technology Center (STC) established by the National Science Foundation in 2013 of eight U.S. research universities aimed at addressing the fundamental questions in biology at the molecular level.

Research Interests

Structure and dynamics of macromolecular assemblies, molecular machines, single-particles methods using X-ray Free-Electron Laser and cryo-Electron Microscopy, data mining of large data sets by Manifold Embedding, Tomography.

Biographical Sketch

Peter Schwander graduated with his PhD in Physics from the Swiss Federal Institute of Technology Zürich (ETHZ), the most prestigious university in Switzerland, and completed postdoctoral studies at AT&T Bell Laboratories in New Jersey. Dr. Schwander returned to Switzerland after completing his postdoctoral work and then joined IHP, a Leibniz Institute for Microelectronics in Frankfurt (Oder), Germany before joining UWM as a Senior Scientist and Adjunct Professor. He worked in that capacity for six years before being promoted to Associate Professor in 2014.

In addition to his academic appoints, Dr. Schwander has served as the Vice President for Research and Development at Lesswire AG in Germany.

Selected Publications

Schwander, Peter, and Schmidt, Marius. Mumbo Jumbo. 2025.
Olmos, Jr, J L., Pandey, S, Martin-Garcia, J M., Calvey, G, Katz, A, Knoska, J, Kupitz, C, Hunter, M S., Liang, M, Oberthuer, D, Yefanov, O, Wiedorn, M, Heyman, M, Holl, M, Pande, K, Barty, A, Miller, M D., Stern, S, Roy-Chowdhury, S, Coe, J, Nagaratnam, N, Zook, J, Verburgt, J, Norwood, T, Poudyal, I, Xu, D, Koglin, J, Seaberg, M H., Zhao, Y, Bajt, S, Grant, T, Mariani, V, Nelson, G, Subramanian, G, Bae, E, Fromme, R, Fung, R, Schwander, Peter, Frank, M, White, T A., Weierstall, U, Zatsepin, N, Spence, J, Fromme, P, Chapman, H N., Pollack, L, Tremblay, L, Ourmazd, Abbas, Phillips, Jr, G N., and Schmidt, Marius. “Enzyme intermediates captured ‘on the fly’ by mix-and-inject serial crystallography.” BMC biology 16.1 (2018): 59.
Pande, Kanupriya, Donatelli, Jeffrey J., Malmerberg, Erik, Foucar, Lutz, Poon, Billy K., Sutter, Markus, Botha, Sabine, Basu, Shibom, Doak, R. B., Dorner, Katerina, Epp, Sascha W., Englert, Lars, Fromme, Raimund, Hartmann, Elisabeth, Hartmann, Robert, Hauser, Guenter, Hattne, Johan, Hosseinizadeh, Ahmad, Kassemeyer, Stephan, Lomb, Lukas, Montero, Sebastian F. Carron, , Menzel, Andreas, Rolles, Daniel, Rudenko, Artem, Seibert, Marvin M., Sierra, Raymond G., Schwander, Peter, Ourmazd, Abbas, Fromme, Petra, Sauter, Nicholas K., Bogan, Michael, Bozek, John, Bostedt, Christoph, Schlichting, Ilme, Kerfeld, Cheryl A., and Zwart, Petrus H. “Data Descriptor: Free-electron laser data for multiple-particle fluctuation scattering analysis.” SCIENTIFIC DATA 5. (2018).
Pande, Kanupriya, Donatelli, Jeffrey, Malmerberg, Erik, Foucar, Lutz, Poon, Billy, Sutter, Markus, Botha, Sabine J., Basu, Shibom, Doak, Bruce, Dörner, Katerina, Epp, Sascha W., Englert, Lars, Fromme, Raimund, Hartmann, Elisabeth, Hartmann, Robert, Hauser, Guenter, Hattne, Johan, Hosseinizadeh, Ahmad, Kassemeyer, Stephan, Lomb, Lukas, Carron Montero, Sebastian F., Menzel, Andreas, Rolles, Daniel, Rudenko, Artem, Seibert, Marvin M., Sierra, Raymond G., Schwander, Peter, Ourmazd, Abbas, Fromme, Petra, Sauter, Nicholas K., Bogan, Michael, Bozek, John, Bostedt, Christoph, Schlichting, Ilme, Kerfeld, Cheryl A., and Zwart, Petrus H. “Free-electron laser data for multiple-particle fluctuation scattering analysis Light Source.” Nature – Scientific Data. (2018).
Hosseinizadeh, Achmad, Mashayekhi, Goncheh, Copperman, Jeremy, Schwander, Peter, Dashti, Ali, Sepehr, Reyhaneh, Fung, Russel, Schmidt, Marius, Yoon, Chuck, Hogue, Brenda, Williams, Garth J., Aquilla, Andy, and Ourmazd, Abbas. “Conformational Landscape of a Virus by Single-particle X-ray Scattering.” Nature Methods online. (2017).
Ahmad, Hosseinizadeh, Ghoncheh, Mashayekhi, Jeremy, Copperman, Schwander, Peter, Ali, Dashti, Russell, Fung, Marius, Schmidt, Yoon, Brenda, Hogue, Andrew, Aquila, and Ourmazd, Abbas. “Conformational Landscape of a Virus by Single-particle X-ray Scattering.” Nature Methods 14.9 (2017): 877–881.
Reddy, Hemanth K., Yoon, Chun Hong, Aquila, Andrew, Awel, Salah, Ayyer, Kartik, Barty, Anton, Berntsen, Peter, Bielecki, Johan, Bobkov, Sergey, Bucher, Maximilian, Carini, Gabriella A., Carron, Sebastian, Chapman, Henry, Daurer, Benedikt, DeMirci, Hasan, Ekeberg, Tomas, Fromme, Petra, Hajdu, Janos, Hanke, Max F., Hart, Philip, Hogue, Brenda G., Hosseinizadeh, Ahmad, Kim, Yoonhee, Kirian, Richard A., Kurta, Ruslan P., Larsson, Daniel S., Loh, Duane N., Maia, Filipe R., Mancuso, Adrian P., Mühlig, Kerstin, Munke, Anna, Nam, Daewoong, Nettelblad, Carl, Ourmazd, Abbas, Rose, Max, Schwander, Peter, Seibert, Marvin, Sellberg, Jonas A., Song, Changyong, Spence, John C., Svenda, Martin, Van der Schot, Gijs, Vartanyants, Ivan A., Williams, Garth J., and Xavier, P. Lourdu. “Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source.” Nature – Scientific Data Scientific Data 4.Article number: 170079 (2017).
Kupitz, Christoper, Schwander, Peter, and et al. “Structural enzymology using X-ray free electron lasers.” Structural Dynamics 4. Ed. Schwander, Peter. (2017): 044003.
Dashti, Ali, Hail, Danya B., Mashayekhi, Ghoncheh, Schwander, Peter, des Georges, Amadee, Frank, Joachim, and Abbas. “Conformational Dynamics and Energy Landscapes of Ligand Binding in RyR1.” bioRxiv. (2017).
Munke, Anna, Andreasson, Jakob, Aquila, Andrew, Awel, Salah, Ayyer, Kartik, Barty, Anton, Bean, Richard J., Berntsen, Peter, Bielecki, Johan, Boutet, Sébastien, Bucher, Maximilian, Chapman, Henry N., Daurer, Benedikt J., DeMirci, Hasan, Elser, Veit, Fromme, Petra, Hajdu, Janos, Hantke, Max F., Higashiura, Akifumi, Hogue, Brenda G., Hosseinizadeh, Ahmad, Kim, Yoonhee, Kirian, Richard A., Reddy, Hemanth K., Lan, Ti-Yen, Larsson, Daniel S., Liu, Haiguang, Loh, Duane N., Maia, Filipe R., Mancuso, Adrian P., Mühlig, Kerstin, Nakagawa, Atsushi, Nam, Daewoong, Nelson, Garrett, Nettelblad, Carl, Okamoto, Kenta, Ourmazd, Abbas, Rose, Max, van der Schot, Gijs, Schwander, Peter, Seibert, Marvin M., Sellberg, Jonas A., Sierra, Raymond G., Song, Changyong, Svenda, Martin, Timneanu, Nicusor, Vartanyants, Ivan A., Westphal, Daniel, Wiedorn, Max O., Williams, Garth J., Xavier, Paulraj Lourdu, Yoon, Chun Hong, and Zook, James. “Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source.” Nature – Scientific Data. (2016).
Pande, Kanupriya, Hutchinson, Christopher D., Groenhof, Gerrit, Aquilla, Andy, Robinson, Joe S., Tenboer, Jason, Basu, Shibom, DePonte, Daniel D., Liang, Meng, White, Thomas, Zatsepin, Nadia A., Yefanov, Oleksandr, Morozov, Dimitry, Oberthuer, Dominik, Gati, Cornelius, Subramanian, Ganesh, James, Daniel, Zhao, Yun, Koralek, Jacob, Brayshaw, Jennifer, Kupitz, Christopher, Conrad, Chelsie, Roy-Showdhuri, Shatabdi, Coe, Jesse D., Metz, Markus, Xavier, Poulray L., Grant, Thomas E., Koglin, Jason E., Ketawala, Gihan, Fromme, Raimund, Srajer, Vukica, Henning, Robert, Spence, John C., Ourmazd, Abbas, Schwander, Peter, Weierstall, Uwe, Frank, Matthias, Fromme, Petra, Barty, Anton, Chapman, Henry N., Moffat, Keith, van Thor, Jasper J., and Schmidt, Marius. “Femtosecond Structural Dynamics Drives the Trans/Cis Isomerization in Photoactive Yellow Protein.” Science 352. (2016): 725-729.
Hosseinizadeh, Ahmad, Dashti, Ali, Schwander, Peter, Fung, Russell, and Ourmazd, Abbas. “Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges.” STRUCTURAL DYNAMICS. (2015).
Pande, Kanupriya, Schmidt, Marius, Schwander, Peter, and Saldin, Dilano. “Simulations on time-resolved structure determination of uncrystallized biomolecules in the presence of shot noise.” STRUCTURAL DYNAMICS 2. (2015).
Dashti, Ali, Schwander, Peter, Langlois, Robert, Fung, Russell, Li, Wen, Hosseinizadeh, Ahmad, Liao, Hstau Y., Pallesen, Jesper, Sharma, Gyanesh, Stupina, Vera A., Simon, Anne E., Dinman, Jonathan D., Frank, Joachim, and Ourmazd, Abbas. “Trajectories of the ribosome as a Brownian nanomachine.” Proceedings of the National Academy of Sciences of the United States of America 111.49 (2014): 17492-7.
Tenboer, Jason, Basu, Shibom, Zatsepin, Nadia, Pande, Kanupriya, Milathianaki, Despina, Frank, Matthias, Hunter, Mark, Boutet, Sebastien, Williams, Garth, Koglin, Jason E., Oberthuer, Dominik, Heymann, Michael, Kupitz, Chris, Conrad, Chelsie, Coe, Jesse, Roy-Chowdhury, Shatabti, Weierstall, Uwe, James, Dan, Wang, Dingjie, Grant, Tom, Barty, Anton, Yefanov, Oleksandr, Scales, Jennifer, Gati, Cornelius, Seuring, Carolin, Srajer, Vukica, Henning, Robert, Schwander, Peter, Fromme, Raimund, Ourmazd, Abbas, Moffat, Keith, Van Thor, Jasper J., Spence, John C., Fromme, Petra, Chapman, Henry, and Schmidt, Marius. “Time Resolved Serial Crystallography Captures High Resolution Intermediates of Photoactive Yellow Protein.” Science 346.6214 (2014).
Pande, Kanupriya, Schwander, Peter, Schmidt, Marius, and Saldin, Dilano K. “Deducing fast electron density changes in randomly orientated uncrystallized biomolecules in a pump-probe experiment.” Philosophical Transactions of the Royal Society B 369.1647 (2014): 20130332.
Schwander, Peter, Fung, Russell, and Ourmazd, Abbas. “Conformations of Macromolecules and their Complexes from Heterogeneous Datasets.” Philosophical Transactions of the Royal Society B 369.1647 (2014).
Hosseinizadeh, Ahmad, Schwander, Peter, Dashti, Ali, Fung, Russell, D’Souza, Roshan M., and Ourmazd, Abbas. “High-resolution structure of viruses from random diffraction snapshots.” Philosophical Transactions of the Royal Society B 369.1647 (2014).
Poon, H.-C., Schwander, Peter, Uddin, Miraj, and Saldin, Dilano K. “Fiber Diffraction without Fibers.” Physical Review Letters 110.265505 (2013).
Schwander, Peter, Giannakis, D., Yoon, C. H., and Ourmazd, A. “The Symmetries of Image Formation by Scattering. II Applications.” Optics Express 20.12 (2012): 12827-12849.
Giannakis, D., Schwander, Peter, and Ourmazd, A. “The Symmetries of Image Formation by Scattering. I Theoretical Framework.” Optics Express 20.12 (2012): 12799-12826.
Saldin, D. K., Poon, H.-C., Schwander, Peter, Uddin, M., and Schmidt, M. “Reconstructing an icosahedral virus from single-particle diffraction experiments.” Optics Express 19.18 (2011): 17318-17335.
Yoon, C. H., Schwander, Peter, Ourmazd, Abbas, and . “Unsupervised Classification of Single-Particle X-Ray Diffraction Snapshots by Spectral Clustering.” Optics Express 19.17 Ed. al., et. (2011): 16542-16549.
Schwander, Peter, Fung, Russell, Philips Jr., George N., and Ourmazd, Abbas. “Mapping the Conformations of Biological Assemblies.” New Journal of Physics 12.035007 (2010).