Skwor, Troy

Milwaukee Institute for Drug Discovery (MIDD)

Assistant Professor of Biomedical Science


Postdoctoral Fellow  Children’s Hospital Oakland Research Institute.

Ph D Medical Sciences Texas A&M University College of Medicine.

BS Medical Microbiology and Immunology University of Wisconsin–Madison.

Interests & Expertise

Troy Skwor’s research focuses on antibiotic resistance within different bacterial populations, especially within Aeromonas species. These bacteria are found ubiquitously in nature, especially in freshwater ecosystems. However, they have been associated with a wide array of human diseases ranging from diarrhea to wound infections to more severe forms of disease, including necrotizing fasciitis. Besides being ubiquitous in nature, the rapid acquisition of antibiotic resistance against a broad array of antibiotics can present a clinical challenge. Additionally, it can serve as a vehicle to transfer antibiotic resistance genes to other pathogenic bacteria. Due to the bacterial presence in aquatic ecosystems, various foods, wastewater, and humans, his research uses Aeromonas as an indicator species to further understand the driving forces behind antimicrobial resistance. 

Another aspect of his research is studying alternative treatments against bacterial populations with an emphasis on photodynamic inactivation. This type of therapy uses a chemical, known as photosensitizer, in the presence of different wavelengths of visible light and oxygen, to produce reactive oxygen species capable of killing bacteria, including multi-drug resistant strains.  

He has a strong interest in mentoring students and helping them develop their critical thinking skills.  

Selected Publications

Liedhegner, E. S., Bojar, B., Beattie, R., Cahak, C., Hristova, K., & Skwor, T. (2022, February). Similarities in virulence and extended spectrum beta-lactamase gene profiles among cefotaxime-resistant Escherichia coli wastewater and clinical isolates. Antibiotics/MDPI11(2), 260-278.
Bojar, B., Sheridan, J., Beattie, R., Cahak, C., Liedhegner, E., Munoz-Price, L., Hristova, K., & Skwor, T. (2021, September). Antibiotic resistance patterns of Escherichia coli isolates from the clinic through the wastewater pathway e clinic through the wastewater pathway. International Journal of Hygiene and Environmental Health238, 113863-113873.
Heffron, J., Bork, M., Meyer, B., & Skwor, T. (2021, March). A comparison of porphyrin photosensitizers in photodynamic inactivation of RNA and DNA bacteriophages. Viruses13(3), 530.
Leviskas, B., Valyi-Nagy, T., Munirathinam, G., Bork, M., Valyi-Nagy, K., & Skwor, T. (2020, January (1st Quarter/Winter)). Metalloporphyrin Pd(T4) Exhibits Oncolytic Activity and Cumulative Effects with 5-ALA Photodynamic Treatment against C918 Cells. International Journal of Molecular Sciences21(2), 669.
Skwor, T., Stringer, S., Haggerty, J., Johnson, J., Duhr, S., Johnson, M., Seckinger, M., & Stemme, M. (2020, January (1st Quarter/Winter)). Prevalence of Potentially Pathogenic Antibiotic-Resistant Aeromonas spp. in Treated Urban Wastewater Effluents versus Recipient Riverine Populations: a 3-Year Comparative Study. Elkins, Christopher A. (Ed.). Applied and Environmental Microbiology86(3).
Beattie, R., Skwor, T., & Hristova, K. (2020, October (4th Quarter/Autumn)). Survivor microbial populations in post-chlorinated wastewater are strongly associated with untreated hospital sewage and include ceftazidime and meropenem resistant populations. Science of The Total Environment740.
Gheewala, T., Skwor, T., & Munirathinam, G. (2018, March). Photodynamic therapy using pheophorbide and 670 nm LEDs exhibits anti-cancer effects in-vitro in androgen dependent prostate cancer. Photodiagnosis and Photodynamic Therapy21, 130-137.
Gheewala, T., Skwor, T., & Munirathinam, G. (2017, May). Photosensitizers in prostate cancer therapy. Oncotarget8(18).
Skwor, T., Klemm, S., Zhang, H., Schardt, B., Blaszczyk, S., & Bork, M. A. (2016, December). Photodynamic inactivation of methicillin-resistant Staphylococcus aureus and Escherichia coli: A metalloporphyrin comparison. Journal of Photochemistry and Photobiology B: Biology165, 51-57.
Skwor, T., Shinko, J., Augustyniak, A., Gee, C., & Andraso, G. (2014, February). Aeromonas hydrophila and Aeromonas veronii Predominate among Potentially Pathogenic Ciprofloxacin- and Tetracycline-Resistant Aeromonas Isolates from Lake Erie. Applied and Environmental Microbiology80(3), 841-848.
Wasson, C. J., Zourelias, J. L., Aardsma, N. A., Eells, J. T., Ganger, M. T., Schober, J. M., & Skwor, T. (2012). Inhibitory effects of 405 nm irradiation on Chlamydia trachomatis growth and characterization of the ensuing inflammatory response in HeLa cells. BMC Microbiology12(1), 176.