Liedhegner, Elizabeth
liedhegn@uwm.edu

Liedhegner, Elizabeth

Member
Milwaukee Institute for Drug Discovery (MIDD)

Assistant Professor of Biomedical Science

Education

Ph D Pharmacology,  Case Western Reserve University 2010.

BS Biochemistry,  Spring Hill College 2004.

Interest & Expertise

Dr. Elizabeth Liedhegner is a Team Scientist in the department of Biomedical Sciences at the University of Wisconsin Milwaukee, engaged in understanding cellular signaling pathways in disease processes. She obtained her PhD in 2011 from Case Western Reserve University focusing the utilization of a neuronal cell model to study the oxidative stress and cell signaling pathways induced by the utilization of Levodopa therapy to treat Parkinson's Disease. Dr. Liedhegner conducted her postdoctoral studies at the Medical College of Wisconsin where she utilized mammalian models to study endocannabinoid trafficking mechanism alterations related to post-traumatic stress disorder.

Dr. Liedhegner's current research programs are focused on exploring cellular signaling mechanisms, including oxidative changes, that impact protein function and cellular health in various altered states, such as disease and trauma. The overall goal of this research is to define cellular mechanisms in culture systems and animal models that are important to disease and disorder development and progression. For this research, she employs a variety of techniques to assay whole cells including live cell imaging and immunofluorescent staining techniques, examination of signaling changes through reporter assays, and protein modifications that result in altered cellular signaling

Selected Publications

Liedhegner, E. S., Bojar, B., Beattie, R., Cahak, C., Hristova, K., & Skwor, T. (2022, February). Similarities in virulence and extended spectrum beta-lactamase gene profiles among cefotaxime-resistant Escherichia coli wastewater and clinical isolates. Antibiotics/MDPI, 11(2), 260-278.
Liedhegner, E. S., Sasman, A., & Hillard, C. J. (2014). Brain region-specific changes in N-acylethanolamine contents with time of day. Journal of Neurochemistry, 128(4), 491-506.
Liedhegner, E. S., Vogt, C. D., Sem, D. S., Cunningham, C. W., & Hillard, C. J. (2014). Sterol carrier protein-2: Binding protein for endocannabinoids. Molecular Neurobiology, 50(1), 149-158.
Sabens Liedhegner, E. A., Gao, X. H., & Mieyal, J. J. (2012). Mechanisms of altered redox regulation in neurodegenerative diseases – Focus on glutathionylation. Antioxidants and Redox Signaling, 16(6), 543-566.
Sabens Liedhegner, E. A., Stellar, K. M., & Mieyal, J. J. (2011). Levodopa activates ASK1 through oxidative dissociation of protein modulators and induces cell death. Journal of Chemical Research and Toxicology, 24(10), 1644-1652.
Sabens, E. A., Distler, A. M., & Mieyal, J. J. (2010). Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes Neuronal cell death - Implications for therapy of parkinson’s disease. Biochemistry, 49(12), 2715-2724.
Sabens, E. A., & Mieyal, J. J. (2009). Glutaredoxin and thioredoxin enzyme systems: Catalytic mechanisms and physiological functions. Massala, Mazza, G., & Hoboken, G. (Eds.). Glutathione and Sulfer Amino Acids in Human Health and Disease, 121-156.
Mieyal, J. J., Gallogly, M. M., Qanungo, S., Sabens, E. A., & Shelton, M. D. (2008). Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal, 10(11), 1941-1988.
Offer, T., Ames, B. N., Bailey, S. W., Sabens, E. A., Nozawa, M., & Ayling, J. E. (2007). 5-methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA. The FASEB Journal, 21(9), 2101-2107.

Honors & Awards

Dean's Award for Outstanding Service (2021, May 7) UWM College of Health Sciences.

International Cannabinoid Research Symposium travel award (2012) National Institutes of Health (NIH).

International Cannabinoid Research Symposium travel award (2011) National Institutes of Health (NIH).
Postdoctoral poster presentation winner (2011) Milwaukee Chapter Society of Neuroscience.
3rd place poster presentation (2010) Research ShowCASE.
Gordon Research Conference Travel Award (2010) National Science Foundation.
Biomedical Graduate Student Symposium poster presentation winner (2009) .
Predoctoral Fellowship: NIH Institutional Metabolism Training Grant (T32 DK007319) (2009) National Institutes of Health (NIH).
Greenfield Travel Award: Best journal club presentation (2006) CWRU Department of Pharmacology.
Predoctoral Fellowship: NIH Institutional Molecular Training Grant (T32 GM008803) (2005) National Institutes of Health (NIH).