Webb, Daniel
dawebb@uwm.eduChemistry CHM 844,

Webb, Daniel

Ph.D. Student
Chemistry & Biochemistry

Education

University of Wisconsin-Milwaukee, 2015-2019, B.S., Chemistry

Why I like Chemistry

I like chemistry because of the puzzle-like nature of many of the problems that are encountered. Furthermore, I enjoy the countless real world applications that so much of chemistry accounts for.

Why I chose the Chemistry and Biochemistry Program at UW-Milwaukee

I chose the Chemistry and Biochemistry Program at UW-Milwaukee because of connections that I have made while completing my undergraduate degree in Milwaukee, and because of the incredibly interesting research that is happening.

Favorite things to do in Milwaukee

My favorite things to do in Milwaukee are bike, go to bucks and brewers games, and go to the third ward.

Research Lab: Prof. Alexander Arnold

Major Area of Focus: Organic Chemistry

Thesis: A) Improvements of the Synthesis of Calcitroic Acid; B) Synthesis of New Imidazodiazepines to Target Peripherally Expressed GABA(A) Receptors

Linkedin    ResearchGate  ORCID

Publications

  1. Daniel A. Webb, Maija Lee and Leggy A. Arnold “Modulating Vitamin D Receptor–Coregulator Binding with Small Molecules” in Vitamin D, Volume 2: Health, Disease and Therapeutics, David Feldman, Ed.; Academic Press, Fifth Edition, 2023.
  2. Daniel A. Webb, Zeid Alsudani, Guolin Xu, Peng Gao, and Leggy A. Arnold “Improved 2-Pyridyl Reductive Homocoupling Reaction Using Biorenewable Solvent CyreneTM (dihydrolevoglucosenone)”, RSC Sustainability 2023,1(6), 1522-1529.
  3. Daniel A Webb, Michelle J Meyer, Kayode M Medubi, Anika S Tylek, Gene T Yocum, M S Rashid Roni, Nicolas M Zahn, Sarah A Swartwout, Ahmad K Masoud, Charles W Emala, Douglas C Stafford, Leggy A Arnold “Design, Synthesis, and Biological Evaluation of Novel Spiro Imidazobenzodiazepines to Identify Improved Inhaled Bronchodilators” J Med Chem, 2023, 66(14), 9853-9865.
  4. Jose F. Perez-Zoghbi, Dannah Rae Sajorda, Daniel A Webb, Leggy A Arnold, Charles W. Emala, and Gene T Yocum “Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization" American Journal of Respiratory Cell and Molecular Biology 2022,  67(4), 482-490.
  5. M.S. Rashid Roni, Nicolas M. Zahn, Gene T. Yocum, Daniel A. Webb, Md Yeunus Mian, Michelle J. Meyer, Anika S. Tylek, James M. Cook, Charles W. Emala, Douglas C. Stafford and Leggy A. Arnold “Comparative pharmacodynamic and pharmacokinetic study of MIDD0301 and its (S) enantiomer" Drug Development Research 2022, 83(4), 979-992.
  6. Nicolas M. Zahn, M.S. Rashid Roni, Gene T. Yocum, Michelle J. Meyer, Daniel A. Webb, Md Yeunus Mian, James M. Cook, Douglas C. Stafford, Charles W. Emala, and Leggy A. Arnold "Development of inhaled GABA(A) receptor modulators to improve airway function in bronchoconstrictive disorders" ACS Pharmacology & Translational Science 2022, 5(2), 80-88.
  7. M.S. Rashid Roni, Nicolas M. Zahn, Brandon N. Mikulsky, Daniel A. Webb, Md Yeunus Mian, Daniel E. Knutson, Margaret L. Guthrie, James M. Cook, Douglas C. Stafford, Leggy A. Arnold “Identification and Quantification of MIDD0301 metabolites” Current Drug Metabolism 2021, 22(14), 1114-1123.
  8. Olivia B. Yu, Daniel A. Webb, Elliot S. Di Milo, Tania R. Mutchie, Kelly A. Teske, Taosheng Chen, Wenwei Lin, Carole Peluso-Iltis, Natacha Rochel, Moritz Helmstädter, Daniel Merk and Leggy A. Arnold, “Biological Evaluation and Synthesis of Calcitroic Acid” Bioorganic Chemistry 2021, 116, 105310.
  9. Tania R. Mutchie, Daniel A. Webb, Elliot S. Di Milo and Leggy A. Arnold “Strategy for the Design for Vitamin D Receptor Ligands” in Nuclear Receptors Mostafa Z. Badr Ed.: Springer Nature, Cham Switzerland, 2021, 199-217.

 Poster Presentations

  1. Daniel A. Webb, Michelle J. Meyer, Anika S. Tylek, Kayode M. Medubi, Ahmad K. Masoud, Sarah A. Swartwout, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford and Leggy A. Arnold “Synthesis, Biological Evaluation, and Molecular Modeling of Novel Imidazobenzodiazepines to Identify Lead Compounds for the Oral Treatment of Asthma” Chemistry and Biochemistry Research Symposium, UWM, Milwaukee, April 28th, 2023.
  2. Daniel A. Webb, Michelle J. Meyer, Anika S. Tylek, Kayode M. Medubi, Ahmad K. Masoud, Sarah A. Swartwout, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford and Leggy A. Arnold “Synthesis, Biological Evaluation, and Molecular Modeling of Novel Imidazobenzodiazepines to Identify Lead Compounds for the Oral Treatment of Asthma” Herbert C. Brown Lectures in Organic Chemistry 2023 Symposium, April 14th, 2023.
  3. Daniel A. Webb, Michelle J. Meyer, Anika S. Tylek, Kayode M. Medubi, Ahmad K. Masoud, Sarah A. Swartwout, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford and Leggy A. Arnold “Synthesis, Biological Evaluation, and Molecular Modeling of Novel Imidazobenzodiazepines to Identify Lead Compounds for the Oral Treatment of Asthma” American Chemical Society ACS Meeting, March 28th, 2023. Poster #835.
  4. Daniel A. Webb, Zeid Alsudani, Guolin Xu, Peng Gao and Leggy A. Arnold “CyreneTM (dihydrolevoglucosenone) as Green Solvent to Improve the Efficiency of a Reductive Homocoupling Reaction with Substituted Pyridines” American Chemical Society ACS Meeting, March 28th, 2023. Poster #330.
  5. Daniel A. Webb, Douglas C. Stafford and Leggy A. Arnold, “Docking and Computational Studies of Novel Disubstituted Imidazobenzodiazepines”, MIDD symposium 2023, February 17th, 2023.
  6. Daniel A. Webb and Leggy A. Arnold, “Evaluation of Novel Benzodiazepines for the Potential Oral Treatment of Asthma”, oral presentation, MIDD symposium 2023, February 17th, 2023.
  7. Milwaukee Analytical Chemistry Conference: “Determination of Solubility and Permeability for Novel Imidazobenzodiazepines with Potential Application as an Orally Available Asthma Medication” Daniel A. Webb, Douglas C. Stafford, and Leggy A. Arnold*, August 29, 2022.
  8. ACS National Meeting and Exposition, Chicago, IL: “Synthesis and Evaluation of Disubstituted Imidazodiazepines Using a Novel Synthetic Strategy to Generate Compounds with Potential Application as an Orally Available Asthma Medication” Daniel A. Webb, Michelle J. Meyer, Anika S. Tylek, Sarah A. Swartwout, Md S. Rashid Roni, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford and Leggy A. Arnold*, August 21, 2022.
  9. Chemistry & Biochemistry Research Symposium & Awards Day: “Synthesis and Evaluation of Disubstituted Imidazodiazepines Using a Novel Synthetic Strategy to Generate Compounds with Potential Application as an Orally Available Asthma Medication” Daniel A. Webb, Michelle J. Meyer, Anika S. Tylek, Sarah A. Swartwout, Md S. Rashid Roni, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford and Leggy A. Arnold*, April 22, 2022.
  10. MIDD Symposium: “Development of a Novel Synthetic Strategy That Enables the Generation of Disubstituted Imidazodiazepines with Potential Application as Orally Available Asthma Medication”, Daniel Webb, Md S. Rashid Roni, Md Yeunus Mian, Douglas C. Stafford, James M. Cook, Leggy A. Arnold*, January 18, 2022.
  11. 46th Annual UW-System Chem Faculties Meeting: “Development of a Novel Synthetic Strategy That Enables the Generation of Disubstituted Imidazodiazepines with Potential Application as Orally Available Asthma Medication”, Daniel Webb, Md S. Rashid Roni, Md Yeunus Mian, Douglas C. Stafford, James M. Cook, Leggy A. Arnold*, November 4, 2021.
  12. ACS Milwaukee Fall Poster Session: “Development of a Novel Synthetic Strategy That Enables the Generation of Disubstituted Imidazodiazepines with Potential Application as Orally Available Asthma Medication”, Daniel Webb, Md S. Rashid Roni, Md Yeunus Mian, Douglas C. Stafford, James M. Cook, Leggy A. Arnold*, October 27, 2021.
  13. Biohealth Communication Competition at 2021 Biohealth Summit: “Structure Activity Relationship of Oral Asthma Drug Candidate”, Daniel Webb, October 7, 2021.
  14. Chemistry & Biochemistry Research Symposium & Awards Day: “Synthesis of MIDD0301 Phase II Metabolites and Application of Amino Acid N-Carboxy Anhydrides to Generate New MIDD0301 Analogs”, Daniel Webb, Md S. Rashid Roni, Md Yeunus Mian, Douglas C. Stafford, James M. Cook, Leggy A. Arnold*, April 23, 2021.
  15. Undergraduate research symposium: “Towards the Synthesis of an Intrinsic Fluorescent Ligand for The Vitamin D Receptor”, Daniel Webb, Tania Mutchie, Rodrigo Ramos, Fernando Ramos, and Leggy A. Arnold*, April 5, 2019.
  16. Chemistry & Biochemistry Research Symposium & Awards Day: “Towards the Synthesis of an Intrinsic Fluorescent Ligand for The Vitamin D Receptor”, Daniel Webb, Tania Mutchie, Rodrigo Ramos, Fernando Ramos, and Leggy A. Arnold*, April 26, 2019.
  17. Chem 584, Advanced Chemistry Lab II: “Determination and Identification of Halogen Exchange Progress by FTIR and NMR”, Daniel Webb, May 14, 2019.

Awards

  • Best Graduate Poster Presentation Award at the Chemistry and Biochemistry Research Symposium, UWM, Milwaukee, April 28th, 2023.
  • Best Poster Award at the Herbert C. Brown Lectures in Organic Chemistry 2023 Symposium, April 14th, 2023.
  • Graduate Student Travel Award, UWM Department of Chemistry & Biochemistry, Fall 2022.
  • Distinguished Dissertator Fellowship, Fall 2022 – Spring 2023
  • 1st place: 2021 ACS Milwaukee Fall Poster Session, October 2021
  • 3rd place: Biohealth Communications Competition, October 2021
  • ACS 2019 Undergraduate Award in Analytical Chemistry