The inaugural Wisconsin WISER conference took place at the Medical College of Wisconsin and was attended by nearly 500 scientists including undergraduate and graduate students from local educational institutions. The conference was a great success supported by an exceptional organizing team including MCW faculty Michaela Patterson. Randeep Pangli from UW-Whitewater was selected for the MIDD sponsored poster award for his contribution ” Boron Prodrugs of Niclosamides for the Treatment of Non-Alcoholic Steatohepatitis”.
Nonalcoholic fatty liver disease (NAFLD) has emerged recently as the leading cause of chronic liver disease, affecting ~20% to 30% of the population in United States alone. Currently, there are no clinically approved drugs specifically indicated for the prevention and treatment of NASH. Repurposing of niclosamide might represent a new treatment strategy, which was evaluated by Mr. Pangli by synthesizing new analogs of niclosamide to improve water solubility, oral bioavailability, and metabolic stability.