Biological Sciences Colloquium: Dr. Matthew Shoulders

Dr Matthew Shoulders of MIT will present a talk about his work entitled, “Collagen Folding and Assembly in the Secretory Pathway.”

The abstract is as follows:

“Collagen is the most abundant protein in humans and the molecular scaffold for animal life. Yet, much remains to be elucidated regarding how cells successfully fold, quality control, and secrete this fundamental and uniquely complex component of the extracellular matrix. Progress towards defining how procollagen trimers are assembled with correct stoichiometries and composition will be discussed. Discoveries regarding key roles of sugar modifications in ensuring collagen proteostasis will also be presented. Connections to diseases of the extracellular matrix and potential therapeutic opportunities will be integrated throughout.”

The presentation will begin at 4:00 PM in Lapham Hall N101, preceded by an informal reception from 3:45 – 4:00 PM.