Project Description
The unfolded protein response (UPR) is a cellular strategy that increases the protein folding capacity of cells. Dysfunctional UPR is the cause of many neurological and metabolic diseases, such as diabetes, arthritis, and certain cancers. Hence, understanding of the UPR mechanisms will help identify the potential therapeutic targets for these diseases. In a high-throughput analysis Jonikas et. al. (Science 2009, PMC2877488) report that multiple conserved factors are critical for the UPR signal. Most of those factors are not yet characterized. In this project, 25 genes will be analyzed for their function in the protein-folding processes in the budding yeast Saccharomyces cerevisiae.
Tasks and Responsibilites
The student will search literatures for the UPR in both yeast and human cells. They will analyze the sequence and structures of UPR regulators and attend the Dey Lab meeting as and when required. The student will conduct molecular and biochemical studies in the Dey Lab.
Desired Qualifications
None Listed.