A. Symposium
Day 1: Monday, August 19, 2019
UW-Milwaukee, Kenwood IRC (KIRC), 3135 North Maryland Ave., Milwaukee,WI
| 08:15 – 08:45 |
REGISTRATION (KIRC Atrium) and BREAKFAST Food served in KIRC Atrium 1140 Seating in KIRC 1130 & 1150 |
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| 08:45 – 09:15 |
OPENING & Welcome (KIRC 1150) Brian Thompson (UWM Research Foundation, and Lubar Entrepreneurship Center, Milwaukee, Wisconsin) |
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SESSION 1 (KIRC Room 1150) Chair: Anne Kenworthy (University of Virginia School of Medicine) |
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| 09:15 – 09:45 |
Keynote 1 Kalina Hristova (Johns Hopkins University) |
EphA2 Receptors: dimerization and structure |
| 09:45 – 10:00 | Keynote 1 Q & A | |
| 10:00 – 10:30 |
Keynote 2 Vali Raicu (University of Wisconsin-Milwaukee) |
2D Forster Resonance Energy Transfer (FRET) and Fluorescence Intensity Fluctuation (FIF) spectrometries |
| 10:30 – 10:45 | Keynote 2 Q & A | |
| 10:45 – 11:15 |
Coffee-fueled Discussion Led by: Paul Park (Case Western) and Graeme Milligan (Glasgow) |
Know the strengths and weaknesses of your fluorescence-based technique for studying receptor oligomerization. |
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SESSION 2 (KIRC Room 1150) Chair: Graeme Milligan (University of Glasgow) |
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| 11:15 – 11:45 |
Keynote 3 Paul Park (Case Western Reserve University) |
Probing the structure of rhodopsin by atomic force microscopy |
| 11:45 – 12:00 | Keynote 3 Q & A | |
| 12:00 – 12:15 |
Short Talk 1 Patrick Byrne (University of Texas – Austin) |
Ligand-independent EGFR/ERbB1 oligomers do not rely on the asymmetric kinase dimer interface |
| 12:15 – 12:25 | Short Talk 1 Q & A | |
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12:30 – 13:30 |
LUNCH (Served in KIRC 1140) Seating in KIRC 1130 and 1150 |
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Symposium, Day 1: Monday, August 19, 2019 (continued)
UW-Milwaukee, Kenwood IRC (KIRC), 3135 North Maryland Ave., Milwaukee, WI
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SESSION 3 (KIRC 1150) Chair: Paul Park (Case Western Reserve University) |
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| 13:30 – 14:00 |
Keynote 4 Anne Kenworthy (University of Virginia Medical School) |
High content imaging to identify novel modulators of membrane rafts |
| 14:00 – 14:15 | Keynote 4 Q & A | |
| 14:15 – 14:30 |
Short Talk 2 Maxim Prigozhin (Stanford University) |
Multicolor electron microscopy |
| 14:30 – 14:40 | Short Talk 2 Q & A | |
| 14:45 – 15:45 |
COFFEE and POSTER VIEWING KIRC Atrium and Rooms 1130&1140 |
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SESSION 4 (KIRC 1150) Chair: Claudiu Gradinaru (University of Toronto at Mississauga) |
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| 15:45 – 16:15 |
Keynote 5 Yinglong Miao (University of Kansas) |
Enhanced sampling of G-protein-coupled receptor-G protein interactions |
| 16:15 – 16:30 | Keynote 5 Q & A | |
| 16:30 – 16:45 |
Short Talk 3 Taras Pogorelov (University of Illinois at Urbana-Champaign) |
Fast pressure jump reveals site-specific protein dehydration-folding dynamics using multiprobes |
| 16:45 – 16:55 | Short Talk 3 Q & A | |
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16:55 – 17:15 |
PICK-UP FOR TRANSPORTION TO DINNER Location: Gather under the pedestrian bridge over North Maryland Ave; same as drop-off point from the morning.
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Shuttle WILL depart at 17:15 |
| 18:00 – 22:00 |
SYMPOSIUM RECEPTION and DINNER Location: Best Place at the Historic Pabst Brewery |
Optional Tour Included |
Symposium, Day 2: Tuesday, August 20, 2019
UW-Milwaukee, Kenwood IRC (KIRC), 3135 North Maryland Ave., Milwaukee, WI
| 08:15 – 08:45 |
BREAKFAST (Served in KIRC 1140) Seating in KIRC 1130 and 1150 |
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SESSION 5 (KIRC Room 1150) Chair: Ionel Popa (University of Wisconsin-Milwaukee) |
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| 08:45 – 09:15 |
Keynote 6 Graeme Milligan (University of Glasgow) |
Assessing the dynamics of GPCR oligomerization: From in vitro to in vivo |
| 09:15-09:30 | Keynote 6 Q & A | |
| 09:30-10:00 |
Keynote 7 Claudiu Gradinaru (University of Toronto at Mississauga) |
Multi-Scale Ligand-induced Dynamics in the A2A Adenosine Receptor |
| 10:00 – 10:15 | Keynote 7 Q & A | |
| 10:15 – 10:30 |
Short Talk 4 Michael Stoneman (University of Wisconsin-Milwaukee) |
An Advanced Optical Micro-Spectroscope for Quantifying Protein Interactions |
| 10:30 – 10:40 | Short Talk 4 Q & A | |
| 10:45 – 11:15 |
Coffee-fueled Discussion Led by: Claudiu Gradinaru (Toronto) and Kalina Hristova (J. Hopkins) |
GPCRs: How do different types of ligands (full/partial agonist, inverse agonist) modulate different structural substates? |
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SESSION 6 (KIRC Room 1150) Chair: Yinglong Miao (University of Kansas) |
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| 11:15 – 11:45 |
Keynote 8 Leggy A. Arnold (University of Wisconsin-Milwaukee) |
Development of a new therapy for asthmas that specifically targets GABAA receptors in the lung |
| 11:45 – 12:00 | Keynote 8 Q & A | |
| 12:00 – 12:15 |
Short Talk 5 Chris King (HHMI, Janelia Research Campus) |
Direct measurements of VEGF:VEGFR2 binding affinities on the plasma membrane |
| 12:15 – 12:25 | Short Talk 5 Q & A | |
| 12:25 – 12:30 | SYMPOSIUM CLOSING | |
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12:30 – 13:30 |
LUNCH (Food served in KIRC 1140) Seating in KIRC 1130 and 1150
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B. RIIO Alliance 2nd General Assembly Meeting
Tuesday, August 20, 2019
UW-Milwaukee, Kenwood IRC (KIRC), 3135 North Maryland Ave., Milwaukee, WI
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RIIO GENERAL ASSEMBLY MEETING KIRC Room 1150
Chair: Vali Raicu (University of Wisconsin – Milwaukee) |
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13:30 – 13:50 |
RIIOA Director Report Vali Raicu (University of Wisconsin-Milwaukee) |
Updates on Alliance membership, structure, etc.; introducing workgroups |
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13:50 – 14:45 |
Member Updates Various
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Successful grant applications, high impact papers, moves, new instruments built/planned, etc. (One to two slides per institution) |
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14:45 – 15:15 |
COFFEE BREAK |
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15:15 – 15:45
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Tour of the UWM Biophysical Microspectroscopy Facility (KIRC 2060) guided by Vali Raicu (UW-Milwaukee) |
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15:45 – 16:45 |
Discussion (KIRC 1150) Led by: Anne Kenworthy (University of Virginia) Yinglong Miao (University of Kansas) and
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Action items, next steps, working groups formation
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16:55 –17:00 |
CLOSING
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17:00 |
Gather for PICK-UP for RETURN to HOTEL (Scenic Tour via “City Tours MKE”)
Location: Gather under the pedestrian bridge over North Maryland Ave. |
Shuttle WILL depart at 17:15 |
For last year’s program information, please see the 2017 website