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Jeri-Anne Lyons, PhD

Associate Professor, Associate Dean

Education

Postdoctoral Fellow Washington University School of Medicine, Department of Neurology, The John L. Trotter Comprehensive MS Center 2000
Ph D Microbiology Medical College of Wisconsin 1997
BS Medical Technology University of Wisconsin-Stevens Point 1989

Speaker Topics

  • Immunology
  • Multiple Sclerosis
  • Phototherapy

Interests & Expertise

Jeri-Anne Lyons conducts research in the field of autoimmunity. In particular, Lyons’ research focuses on Multiple Sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). MS is thought to result from an immune-mediated attack of CNS myelin by autoreactive T cells specific for myelin components.

Specifically, Lyons’ research focuses on the immunopathogenesis of MS and in identifying novel targets for disease. Studies are performed on cells isolated from MS patients and in a mouse model of MS called Experimental Autoimmune Encephalomyelitis (EAE). The role of B cells and antibody in disease pathogenesis are of interest.

Also of interest is the regulation of immune cell activation. Recent studies have focused on a novel therapeutic approach using red led to stimulate repair pathways, termed “Photobiomodulation”. A variety of cellular and molecular techniques are used to study these questions.

Selected Publications

Lyons, J., Riter, M. M., Almatrook, A. M., Ramsbottom, M. J., & Cross, A. H. (2016, November). Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein. Journal of Neuroimmunology, 300, 66-73.
Muili, K. A., Gopalakrishnan, S., Meyer, S. L., Eells, J. T., & Lyons, J. (2013). Photobiomodulation induced by 670nm light ameliorates MOG35-55 induced EAE in female C57BL/6 mice: A role for remediation of nitrosative stress. PLoS One, 8(6), e67358.
Liu, G., Muili, K. A., Agashe, V. V., & Lyons, J. (2012). Unique B cell responses in B cell-dependent and B cell-independent EAE. Autoimmunity, 45(3), 199-209.
Muili, K. A., Gopalakrishnan, S., Meyer, S. L., Eells, J. T., & Lyons, J. (2012). Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by photobiomodulation induced by 670 nm light. PLoS One, 7, 30655.
Monson, N. L., Cravens, P., Hussain, R., Harp, C. T., Cummings, M., de Pilar Martin, M., Ben, L., Do, J., Lovette-Racke, A., Lyons, J., Cross, A. H., Racke, M. K., Stuve, O., Schlomchik, M., & Eagar, T. N. (2011). Rituximab therapy reduces organ-specific t cell responses and ameliorates experimental autoimmune encephalomyelitis. PloS ONE.
Naismith, R. T., Piccio, L., Lyons, J., Lauber, J., Tutlam, N. T., Parks, B. J., Trinkaus, K., Song, S. K., & Cross, A. H. (2010). Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: a 52-week phase II trial. Neurology, 74(23), 1860-1867.
Lyons, J. (2010). A role for the cbl-b E3 ubiquitin ligase in the balance between tolerance and autoimmunity. WiSYS.
Klawiter, E. C., Piccio, L., Lyons, J., Mikesell, R., O’Connor, K. M., & Cross, A. H. (2010). Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis. Archives of Neurology, 67(9), 1102-1108.
Piccio, L., Naismith, R. T., Trinkaus, K., Klein, R. S., Parks, B. J., Lyons, J., & Cross, A. H. (2010). Changes in B and T lymphocytes and chemokines with rituximab treatment in multiple sclerosis. Archives of Neurology, 67(6), 707-714.
Lyons, J., Ramsbottom, M. J., Mikesell, R. J., & Cross, A. H. (2008). B cells limit epitope spreading and reduce severity of EAE induced with PLP peptide in BALB/c mice. J. Autoimmunity, 31, 149-155.
Cross, A. H., Stark, J. L., Lauber, M., Ramsbottom, J., & Lyons, J. (2006). Rituximab reduces B cells and T cells in Cerebrospinal Fluid of Multiple Sclerosis Patients. J. Neuroimmunology, 180, 63-70.
Stark, J. L., Lyons, J., & Cross, A. H. (2006). Interferon-gamma produced by encephalitogenic cells induces Suppressors of cytokine signaling (SOCS) in primary murine astrocytes. J. of Neuroimmunology, 151(1-2), 195-200.
Cross, A. H., Ramsbottom, M. J., & Lyons, J. (2006). NOS2 regulates cytokine production and VLA-4 expression in experimental autoimmune encephalomyelitis. J. of Neuroimmunology, 173(1-2), 79-86.
Lyons, J., & Cross, A. H. (2005). Endothelial cells and adhesion molecules in experimental autoimmune encephalomyelitis. Lavi, E., & Constantinescu, C. (Eds.). , 151-179. New York/Springer: Experimental models of MS.

Honors & Awards

Research Fellows (2011) Graduate School, University of Wisconsin-Milwaukee.
Dean’s Research Award (2006) College of Health Sciences, University of Wisconsin-Milwaukee.
UWM Foundation Research Award (2006) Graduate School, University of Wisconsin-Milwaukee.
AAI Junior Faculty Travel Award (2005) American Association of Immunologists.
Post-doctoral fellow (1997) National Multiple Sclerosis Society.
Chancellor’s Leadership Award (1989) University of Wisconsin-Stevens Point.