Jennifer A. Doll, PhD
- Associate Professor, Head of School, Biomedical Sciences Programs, Office of the Dean
Education
Postdoctoral Fellowship Dept. of Microbiology-Immunology Northwestern University Feinberg School of Medicine 2003
Ph D Molecular Genetics Washington University 1997
MS Molecular Biology Loyola University 1992
BS Biology Rockhurst College 1990
Speaker Topics
- Cancer biology
- Prostate cancer
- Obesity and dietary fats in prostate cancer
- Angiogenesis
Interests & Expertise
Jennifer Doll’s research is centered around prostate cancer (PCa) and the effects of obesity and a high fat diet on disease progression. Her work has evolved around the study of two angiogenesis inhibitors, pigment epithelium-derived factor (PEDF) and thrombospondin-1 (TSP-1). Angiogenesis, the growth of new blood vessels from the existing vasculature, is a necessary step for the progressive growth of tumors. Both TSP-1 and PEDF are expressed in the normal prostate but, in PCa patient tissues, expression is decreased or absent, thus suggesting a role in disease progression.
Interestingly, several lines of data suggest that both of these proteins also function in regulating lipid metabolism. This is of particular interest in PCa as a high fat diet and obesity have been consistently associated with more aggressive disease and increased risk of death from PCa. However, the mechanisms of this association remain unclear.
Doll’s research is focused on elucidating these functional mechanism(s) and specifically delineating the role of TSP-1 and PEDF in regulating lipid metabolism in the prostate. Understanding the molecular pathways stimulated in PCa cells by obesity and dietary fats will allow the rational design of novel therapies for treatment as well as new strategies for chemoprevention.
Selected Publications
Helenowski, Irene B., Demirtas, Hakan, Doll, Jennifer A., Jovanovic, Borko D., Gurley, Michael J., Trapp, Luke P., and Kuzel, Timothy M. “The effects of the order of multiple imputation in subset analysis examining the association between body mass index (BMI) and transrectal ultrasound prostate weight.” Convergent Science Physical Oncology 2.3 (2016): 035003.
Iordanescu, G, Brendler, C, Crawford, S E., Wyrwicz, A M., Venkatasubramanian, P N., and Doll, Jennifer A. “MRS measured fatty acid composition of periprostatic adipose tissue correlates with pathological measures of prostate cancer aggressiveness.” Journal of magnetic resonance imaging : JMRI 42.3 (2015): 651-7.
Vekatasubraminian, P N., Brendler, C B., Plunikett, B A., Crawford, S E., Fitchev, P S., Morgan, G, Cornwell, M L., McGuire, M S., Wyrwicz, A M., and Doll, Jennifer A. “Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: A functional and mr imaging pilot study.” The Prostate 74.3 (2014): 326-335.
Gattu, A K., Birkenfeld, A L., Iwakiri, Y, Jay, S, Saltzman, M, Doll, Jennifer A., Protiva, P, Samuel, V T., Crawford, S E., and Chung, C. “Pigment epithelium-derived factor (PEDF) suppresses IL-1β to improve hepatocyte insulin signaling.” Endocrinology 155.4 (2014): 1373-1785.
Principe, D R., Doll, Jennifer A., Bauer, J, Jung, B, Munshi, H G., Bartholin, L, Pasche, B, Lee, C, and Grippo, P J. “TGF-β: Duality of function between tumor prevention and carcinogenesis.” J Natl Cancer Inst 106.2 (2014): djt369.
Yu, N, Kozlowski, J M., Park II, , Chen, L, Zheng, Q, Xu, D, Doll, Jennifer A., Crawford, S E., Brendler, C B., and Lee, C. “Over-expression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.” Urology 76.6 (2010): 1519.e8-13.
Halin, S, Rudolfsson, S H., Doll, Jennifer A., Crawford, S E., Wikstrom, P, and Bergh, A. “Pigment epithelium-derived factor a prostate tumor suppressor with diverse biological effects in the microenvironment.” Neoplasia 12.4 (2010): 336-345.
Fitchev, P P., Wcislak, S M., Lee, C, Bergh, A, Brendler, C B., Stellmach, V M., Crawford, S E., Mavroudis, C D., Cornwell, ML L., and Doll, Jennifer A. “Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and tgf-beta activation.” Lab. Invest 90.7 (2010): 1078-1090.
Chung, C, Shugrue, C, Nagar, A, Doll, Jennifer A., Cornwell, M, Gattu, A, Kolodecik, T, Pandol, S, and Gorelick, F. “Ethanol exposure depletes hepatic pigment epithelium-derived factor (PEDF), a novel lipid regulator in the liver.” Gastroenterology 136.1 (2009): 331-340.
Chung, C, Doll, Jennifer A., Gattu, A, Shugrue, C, Cornwell, C, Fitchev, P, and Crawford, S E. “Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).” J. Hepatol 48.3 (2008): 471-478.
Plunkett, B A., Fitchev, P, Doll, Jennifer A., Gerber, S E., Cornwell, M, Greenstein, E P., and Crawford, S E. “Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths.” Reprod Biol 8.2 (2008): 107-120.
Chung, C, Doll, Jennifer A., Stellmach, V M., Gonzales, J, Surapureddi, S, Cornwell, M, Reddy, J K., and Crawford, S E. “Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.” Adv Exp Med Biol 617. (2008): 591-597.
Signaevsky, M, Hobbs, J, Doll, Jennifer A., Liu, N, and Soff, G A. “Role of alternatively spliced tissue factor in pancreatic cancer growth and angiogenesis.” Semin Thromb Hemost 34.2 (2008): 161-169.
Doll, Jennifer A., Hobbs, J E., and Soff, G A. Role of apoptosis in anti-angiogenic cancer therapies. Apoptosis and Senescence in Cancer Chemotherapy and Radiotherapy, 2007.
Hobbs, J E., Zakarija, A, Cundiff, D L., Doll, Jennifer A., Hymen, E, Cornwell, M, Craford, S E., and Soff, G A. “Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model.” Thrombosis Res 120.Suppl 2 (2007): S13-21.
Wang, H, Doll, Jennifer A., Jiang, K, Cundiff, D L., Czarnecki, J S., Wilson, M, Ridge, K, Soff, G A., and . “Differential binding of plasminogen, plasmin, and angiostatin4.5 to cell surface pro-actin: implications for cancer-mediated angiogenesis.” Cancer Res 66.14 (2006): 7211-7215.
Browne, M, Stellmach, V M., Cornwell, M, Chung, C, Doll, Jennifer A., Lee, E J., Jameson, J L., Reynolds, M, Superina, R A., Abramson, L P., and Crawford, S E. “Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.” Pediatric Res 60.3 (2006): 282-287.
Abramson, L P., Browne, M, Stellmach, V M., Doll, Jennifer A., Cornwell, M, Reynolds, M, Arensman, R M., and Crawford, S E. “Pigment epithelium-derived factor (PEDF) targets endothelial and epithelial cells in Wilms’ tumor.” J. Pediatric Surg 41. (2006): 1351-1356.
Doll, Jennifer A., and Soff, G A. Angiostatin: Generation, structure and function of the isoforms. Ed. Platanias, L C. Cancer Treat. Res, 2005: 175-204.
Soff, G A., Wang, H, Cundiff, D L., Jiang, K, Martone, B, Rademaker, A A., Doll, Jennifer A., and Kuzel, T M. “In vivo generation of angiostatin isoforms by administration of a plasminogen activator and a free-sulfhydryl donor: a phase I study of an angiostatic cocktail of tPA and mesna.” Cancer Res 11.17 (2005): 6218-6225.
Ferbend, P, Abramson, L P., Backer, C L., Mavroudis, C, Webb, C L., Doll, Jennifer A., Junewick, J J., and Crawford, S E. “Cardiac plasma cell granulomas: response to oral steroid treatment.” Pediatric Cardiol 25.4 (2004): 406-410.
Halin, S, Wikstrom, P, Rudolfsson, S H., Doll, Jennifer A., Crawford, S E., and Bergh, A. “Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors.” Cancer Research 64.16 (2004): 5664-5671.
Grayhack, J T., Smith, N D., Ilio, K, Wambi, C, Kasjanski, R, Crawford, S E., Doll, Jennifer A., Wang, Z, Lee, C, and Kozlowski, J M. “Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture.” J. Urology 171.1 (2004): 434-438.
Abramson, L P., Stellmach, V, Doll, Jennifer A., Cornwell, M, Arensman, R M., and Crawford, S E. “Wilms’ tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model.” J. Pediatric Surgery 38.3 (2003): 336-342.
Doll, Jennifer A., Stellmach, V, Bouck, N, Bergh, A, Lee, C, Abramson, L P., cORNWELL, M, Pins, M R., Borensztajn, J, and Crawford, S E. “Hormone-sensitive anti-angiogenic pigment epithelium-derived factor regulates the stromal vasculature and epithelium of the prostate and pancreas.” Nature Medicine 9. (2003): 774-780.
Doll, Jennifer A., Zhu, X, Furman, J, Kaleem, Z, Torres, C, Humphrey, P A., and Donnis-Keller, H. “Genetic analysis of prostatic atypical adenomatous hyperplasia (adenosis).” Am. J. Pathol 155.3 (1999): 967-971.
Doll, Jennifer A., Suarez, B K., and Donis-Keller, H. “Association between prostate cancer in black Americans and an allele of the PADPRP pseudogene locus on chromosome 13.” Am. J. Hum. Genet 58.2 (1996): 425-428.
Honors & Awards
Invited talk (2010, September) Prostate Cancer Foundation’s Annual Retreat.
Invitation (poster presentation with oral summary) (2009, November) NCI Translational Science Meeting.
Invitation (poster presentation) (2007, September) DOD prostate cancer IMPaCT meeting.
Travel Grant Award (2001) American Association for Cancer Research.
Travel Grant Award (1998) American Association for Cancer Research.
Travel Grant Award (1998) National Institutes of Health (NIH).
Grant in Aid of Research (1995) Sigma Xi Research Society.
Travel Grant Award (1994) American Association for Cancer Research.
Graduate Research Fellowship (1992) Loyola University.
Grant Aid of Research (1992) Sigma Xi Research Society.
Barbara Wynne Outstanding Biology Student Award (1990) Rockhurst College.
Honors and Magna Cum Laude (1990) Rockhurst College.