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- Biomedical Sciences MS
- Biomedical Sciences Mentor
- Biomedical Sciences: Biomedical Science BS
- Biomedical Sciences: Diagnostic Imaging Degree Completion Program BS
- Biomedical Sciences: Diagnostic Medical Sonography BS
- Biomedical Sciences: Health Sciences BS
- Biomedical Sciences: Health Sciences Degree Completion Program BS
- Biomedical Sciences: Medical Laboratory Science BS
- Biomedical Sciences: Public Health Microbiology BS
- Biomedical Sciences: Radiologic Technology BS
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Jennifer A. Doll, PhD
- Head of School, School of Biomedical Sciences & Health Care Administration
- Associate Dean for Academic Affairs
- Associate Professor, Biomedical Sciences
Speaker Topics
- Cancer biology
- Prostate cancer
- Obesity and dietary fats in prostate cancer
- Angiogenesis
Interests & Expertise
Jennifer Doll’s research is centered around prostate cancer (PCa) and the effects of obesity and a high fat diet on disease progression. Her work has evolved around the study of two angiogenesis inhibitors, pigment epithelium-derived factor (PEDF) and thrombospondin-1 (TSP-1). Angiogenesis, the growth of new blood vessels from the existing vasculature, is a necessary step for the progressive growth of tumors. Both TSP-1 and PEDF are expressed in the normal prostate but, in PCa patient tissues, expression is decreased or absent, thus suggesting a role in disease progression.
Interestingly, several lines of data suggest that both of these proteins also function in regulating lipid metabolism. This is of particular interest in PCa as a high fat diet and obesity have been consistently associated with more aggressive disease and increased risk of death from PCa. However, the mechanisms of this association remain unclear.
Doll’s research is focused on elucidating these functional mechanism(s) and specifically delineating the role of TSP-1 and PEDF in regulating lipid metabolism in the prostate. Understanding the molecular pathways stimulated in PCa cells by obesity and dietary fats will allow the rational design of novel therapies for treatment as well as new strategies for chemoprevention.