Laboratory for Developmental Immunotoxicology

The primary research objectives of the LDI are focused on understanding why the prevalence of childhood diseases of the immune system such as leukemia, autoimmunity, and atopy are all on the rise in recent decades. This includes developing novel prevention and treatment strategies for understanding the mechanisms by which early life immune system issues effect childhood development and even adult diseases can improve public health.

Immune system development and maturation during the fetal and early post-natal life is a highly orchestrated temporal process that is acutely sensitive to the maternal environment. Identification of the cellular and molecular targets underlying a developmental immunotoxicological risk for disease represents a significant gap in our knowledge.New experimental models and paradigms are needed as the yields from existing tools are approaching their zenith.