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Toxicological Effects of Antimicrobials (Triclosan and Triclocarban) and Cyanopeptides (Anabaenopeptins and Cyanopeptolins) in the Nemotode C. elegans

October 16, 2019 @ 2:00 pm - 3:00 pm


Presented by Kade A. Lenz, Doctoral Candidate, Joseph J. Zilber School of Public Health

Environmental contaminants are increasingly detected in surface water, soil, and sediment. There is a concern that environmental contaminants, such as cyanopeptides and antimicrobials pose potential harm to environmental and public health. It is important that scientists evaluate the potential impacts that cyanopeptides and antimicrobials may have on the environment and public health in order to guide stakeholders in determining appropriate policies and regulations. Here we investigated the toxicological effects of two types of commonly detected environmental contaminants, antimicrobials (triclosan and triclocarban) and cyanopeptides (anabaenopeptins and cyanopeptolins), using the model organism Caenorhabditis elegans (C. elegans). Acute lethality and sublethal toxicity of cyanopeptides (anabaenopeptins and cyanopeptolins) and antimicrobials (triclosan and triclocarban) are identified using C. elegans. The examined toxicity endpoints included reproduction, hatching time, growth rate, lifespan, age-related vulval integrity, germline toxicity, and stress response. We examined the potential mechanism of toxicity of the antimicrobials, triclosan and triclocarban and identify the toxicological effects of degradation products produced by triclosan and triclocarban after these chemicals enter the environment. The research presented here demonstrates that cyanopeptides (anabaenoptpins and cyanopeptolins) and antimicrobials (triclosan and triclocarban) pose potential harm to the environment and establishes endpoints for future toxicological studies in the model organism C. elegans. These findings will provide insight into the toxicological effects and mechanism(s) of toxicity that will add to our knowledge of the effects of these environmental contaminants, as well as provide scientific evidence to policy-makers and regulatory agencies for the creation and amendment of environmental regulation policies.


October 16, 2019
2:00 pm - 3:00 pm
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UWM Union Room 191
2200 E. Kenwood Blvd
Milwaukee, WI 53211 United States