This special Physics department colloquium is scheduled for Monday 5\/18\/15 at 3:30 pm in Room 135. Coffee, tea and cookies are served at 3:15 pm in the same room. Anyone is welcome.<\/p>\n
Myosin V: A Molecular Motor designed for intracellular cargo transport<\/strong> Intracellular cargo transport is ciritical for normal cellular function in all living organisms. Myosin V is a molecular motor responsible for carrying a variety of intracellular cargoes. It is a tiny, biological nano-machine that walks along actin filament tracks and powers this movement by hydrolyzing ATP and converting chemical energy into mechanical work. While carrying cargo, each molecule can travel long distances (~1\u00b5m) at a speed of 400 nm\/s, taking 36nm hand-over-hand steps and generating ~2 piconewton forces. Although a single myosin V is sufficient to transport cargo in vitro, a team of motors is required to transport cargo to its destination within cells. I have initiated a unique set of single-molecule biophysical experiments to understand how multiple myosin V motors communicate, cooperate, or even interfere with each other while transporting cargo through the complicated cytoskeletal network of actin tracks. In addition, myosin V-based transport may be regulated by adapter proteins, which are binding partners of myosin V. However, the role of these adapter proteins are poorly understood. Therefore, my long-term research goals are to understand the molecular basis of intracellular cargo transport by teams of molecular motors.<\/p>\n","protected":false},"excerpt":{"rendered":" This special Physics department colloquium is scheduled for Monday 5\/18\/15 at 3:30 pm in Room 135. Coffee, tea and cookies are served at 3:15 pm in the same room. Anyone is welcome. Myosin V: A Molecular Motor designed for intracellular …<\/p>\n","protected":false},"author":63,"featured_media":0,"template":"","meta":{"_acf_changed":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","uwm_wg_additional_authors":[]},"tags":[],"tribe_events_cat":[58],"class_list":["post-2734","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-physics-colloquia","cat_physics-colloquia"],"yoast_head":"\n
\nDr. M. Yusuf Ali<\/strong>, Assistant Professor, Department of Molecular Physiology and Biophysics, College of Medicine, University of Vermont<\/p>\n