1.0Physics & Astronomyhttps://uwm.edu/physicsElle Cochranehttps://uwm.edu/physics/author/cochratcuwm-edu/Physics Colloquium - Adam Oppermanrich600338<blockquote class="wp-embedded-content" data-secret="Ljq0wdvxxe"><a href="https://uwm.edu/physics/event/physics-colloquium-adam-opperman/">Physics Colloquium – Adam Opperman</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://uwm.edu/physics/event/physics-colloquium-adam-opperman/embed/#?secret=Ljq0wdvxxe" width="600" height="338" title="“Physics Colloquium – Adam Opperman” — Physics & Astronomy" data-secret="Ljq0wdvxxe" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript">
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Manifold-based Machine Learning for Scattering Data Adam Opperman, PhD Candidate University of Wisconsin-Milwaukee Department of Physics & Astronomy Small Angle X-ray Scattering (SAXS) is a technique used to capture X-ray diffraction images of proteins in solution, mimicking biological conditions. These images provide insight into the overall shape and structure of the protein. By imaging the protein system at various times during a reaction, dubbed time-resolved SAXS (TR-SAXS), the evolution of the protein structure is observed. These measurements are commonly taken at X-ray Free Electron Laser (XFEL) facilities which generate X-rays with precision and high flux. The Compact X-ray Light Source (CXLS) and accompanying Compact X-ray Free Electron Laser (CXFEL) are under construction at Arizona State University. Due to the compact nature of the source in combination with the yet incomplete development, CXFEL has a reduced level of photon flux available compared to other XFELs. Due to this constraint, new analytical methods are needed to process TR-SAXS data.