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SUMMARY:Physics Colloquium - Thomas D. Killeen
DESCRIPTION:Novel Imaging Techniques for Studying Interactions of Membrane Receptors Among Themselves and with Downstream Signaling Partners\nThomas D. Killeen\, PhD Candidate\nUniversity of Wisconsin-Milwaukee Department of Physics & Astronomy \nCells rely on complex signaling networks to sense and respond to environmental stimuli\, but the bigger picture of how molecular assembly leads to robust cellular signaling is only beginning to emerge.   A major challenge in characterizing cellular signaling is the ability to directly observe the dynamic interactions between membrane receptors and intracellular signaling partners in living cells.  To address this challenge\, this work presents the development of advanced fluorescence imaging and computational analysis tools designed to improve the precision and quantitative power of live-cell micro-spectroscopy for studying protein dynamics in real time. \nI will show how these tools can be used to investigate the interactions between the muscarinic acetylcholine receptor M2 (M2R) and two intracellular signaling partners\, arrestin-2 and arrestin-3\, in living cells. Quantitative imaging revealed distinct differences in arrestin recruitment and membrane association following receptor activation\, providing new insight into receptor regulation and signaling behavior. \nOverall\, this work demonstrates how innovations in fluorescence microscopy and data analysis can expand our ability to probe molecular signaling networks in living systems.
URL:https://uwm.edu/physics/event/physics-colloquium-thomas-d-killeen/
LOCATION:Kenwood IRC 2175\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Physics Colloquia
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DTSTART;TZID=America/Chicago:20260424T130000
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LAST-MODIFIED:20260424T132235Z
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SUMMARY:CGCA Seminar - Matt Miles
DESCRIPTION:Galaxy-Scale Gravitational Wave Detection: The MPTA and the Road Ahead\nDr. Matt Miles\nVanderbilt University \nGravitational waves are emitted across a vast spectrum of frequencies. Ground-based detectors such as LIGO/Virgo/KAGRA observe relatively high-frequency waves from compact object mergers\, while at the other end of the spectrum\, the inspirals of supermassive black hole binaries produce a low-frequency rumble detectable only with a galaxy-scale instrument. By monitoring the pulses emitted by millisecond pulsars distributed across the Milky Way\, pulsar timing arrays construct such a detector\, spanning thousands of light-years. In recent years\, multiple pulsar timing array collaborations have reported mounting evidence for a gravitational wave background permeating the galaxy\, and the international effort to combine data across these experiments is well underway. In this talk\, I will describe how pulsar timing arrays operate\, what we have found so far — with a focus on the MeerKAT Pulsar Timing Array\, which exploits one of the world’s most sensitive radio telescopes — and the road ahead. I will also discuss new tools and techniques being developed to push the frontiers of pulsar timing\, including faster and more accessible timing software\, methods that exploit the full information content of pulse profiles rather than collapsing them to single arrival times\, and novel approaches to measuring pulsar distances using gravitational wave signals themselves.
URL:https://uwm.edu/physics/event/cgca-seminar-matt-miles/
LOCATION:Kenwood IRC 2175\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:CGCA Seminars
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