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DTSTART;TZID=America/Chicago:20250404T153000
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DTSTAMP:20260611T005548
CREATED:20250401T144054Z
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SUMMARY:Physics Colloquium - Shaswat Sardesai
DESCRIPTION:Shashwat Sardesai\, PhD Candidate\, UWM Physics \nCosmic Orchestra: The Gravitational Wave Background \nIn the last year and a half\, the North American Nanohertz Observatory for Gravitational Waves\, and their collaborators\, have detected the presence of a gravitational wave background using pulsar timing arrays. These gravitational waves likely arise from supermassive black hole binaries (SMBHBs) and have periods spanning years or decades. \nIn this talk\, I will go over the basics of PTAs\, the different methods to analyze the background\, as well as the projects I have worked on as a member of the NANOGrav collaboration to try and resolve aspects of the GWB. \nThe event flyer is available here.
URL:https://uwm.edu/physics/event/physics-colloquium-shaswat-sardesai/
LOCATION:Chemistry 108\, 2050 E Kenwood Blvd\, Milwaukee\, WI\, 53201\, United States
CATEGORIES:Physics Colloquia
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DTSTART;TZID=America/Chicago:20250411T153000
DTEND;TZID=America/Chicago:20250411T170000
DTSTAMP:20260611T005548
CREATED:20250402T205328Z
LAST-MODIFIED:20250402T205328Z
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SUMMARY:Physics Colloquium - Sheng Ran
DESCRIPTION:Sheng Ran\, Assistant Professor of Physics\, Washington University \nStrongly Correlation and Topology in Kondo Lattice Systems \nQuantum materials with both strong correlations and nontrivial band structure topology can have novel physics properties that do not exist in the non-correlated counterparts. Recent theoretical work has demonstrated that combination of Kondo physics and nonsymmorphic crystal symmetries can give rise to such strong correlated topological systems. \nIn this talk\, I will present our recent experimental exploration this direction. In one case\, we found intrinsic anomalous Hall effect that seems to break the Fermi liquid scaling relation. In another case\, we have discovered a candidate for topological Kondo insulator. \nThe event flyer is available here.
URL:https://uwm.edu/physics/event/physics-colloquium-sheng-ran/
LOCATION:Chemistry 108\, 2050 E Kenwood Blvd\, Milwaukee\, WI\, 53201\, United States
CATEGORIES:Physics Colloquia
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DTSTART;TZID=America/Chicago:20250417T100000
DTEND;TZID=America/Chicago:20250417T120000
DTSTAMP:20260611T005548
CREATED:20250409T143045Z
LAST-MODIFIED:20250409T143116Z
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SUMMARY:Physics Colloquium – Gabriel Freedman
DESCRIPTION:Speaker: Gabriel Freedman\, PhD Candidate – UWM Physics \nLow-frequency Gravitational Wave Searches and Data Analysis with Hamiltonian Sampling \nThe pulsar timing array community has found evidence for a correlated stochastic signal following the Hellings-Downs pattern indicative of an isotropic stochastic gravitational-wave background (GWB). The most likely source of such a background is a population of supermassive black hole binaries\, and particularly loud individual sources could be detected in future datasets. \nWe present work done towards performing joint Bayesian searches for both the GWB and single sources utilizing the Hamiltonian Monte Carlo sampling algorithm to efficiently explore these complex parameter spaces. We end by discussing applications of these methods to data analysis for the upcoming Laser Interferometer Space Antenna mission. \nLocation: Kenwood IRC 2175 \nTime: 10:00AM – 12:00PM \nDate: April 17th\, 2025
URL:https://uwm.edu/physics/event/physics-colloquium-gabriel-freedman/
LOCATION:KIRC KEN 2175\, 3135 N. Maryland Ave.\, Milwaukee\, 53211
CATEGORIES:Physics Colloquia
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DTSTART;TZID=America/Chicago:20250418T153000
DTEND;TZID=America/Chicago:20250418T170000
DTSTAMP:20260611T005548
CREATED:20250414T212700Z
LAST-MODIFIED:20250414T212728Z
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SUMMARY:Physics Colloquium – Ned Budisa
DESCRIPTION:Speaker: Ned Budisa\, Professor & Research Chair\, Dept. of Chemistry\, University of Manitoba \nExpanding the Genetic Code via Directed Evolution: Tools for Biophysicists\, Materials Science\, and Beyond \nReprogramming the genetic code to include non-canonical amino acids (ncAAs) is a powerful tool in systems bioengineering that combines synthetic biology\, chemistry\, biophysics\, and genome manipulation. This approach enables enhanced protein biosynthesis\, deeper insights into translation\, and the creation of novel functionalities and new-to-nature proteins and other foldamer-scaffolds. Expansion of the genetic code results in proteins and cells with new properties\, including site-specific functionalization through various bioorthogonal chemistries. \nAt the heart of this endeavor are aminoacyl-tRNA synthetases (aaRS)\, whose modified forms – paired with cognate tRNAs – form orthogonal translation systems (OTS) for precise incorporation of ncAAs\, often via amber stop codons. Directed evolution under selective pressure is used to remodel the active aaRS center to accept specific ncAAs. Traditional gene libraries focus on the first-shell residues (<6 Å) and are constrained by the transformation limits of E. coli (~10⁸–10⁹ variants)\, often neglecting second-shell interactions (<9 Å). To overcome this\, computational enzyme design and novel wet-lab strategies are driving the evolution of effective binding pockets and cellular compatibility with exotic chemicals. \nI will illustrate these approaches using (i) directed evolution of enzyme pockets\, (ii) adaptive laboratory evolution of the amino acid repertoire\, and (iii) genomic integration of orthogonal translation machineries for synthetic cell design. \nFinally\, I will provide an overview of ncAAs that are valuable for biological spectroscopy and microscopy. These site-specifically incorporated ncAAs serve as vibrational\, fluorescent\, EPR\, or NMR probes in cellular\, organismic\, and in vitro contexts. Over the last two decades\, their use has provided unprecedented insights into protein structure and dynamics. Bioorthogonal reactions – in particular Click Chemistry – provide powerful tools to introduce labels or mimic post-translational modifications. Applications now include capturing transient interactions\, tuning protein function and generating therapeutic agents such as covalent peptides and site-specific labeled antibody conjugates. \nLocation: Chemistry 108\nTime: 3:30PM – 5:00PM\nDate: April 18th\, 202
URL:https://uwm.edu/physics/event/physics-colloquium-ned-budisa/
LOCATION:Chemistry 108\, 2050 E Kenwood Blvd\, Milwaukee\, WI\, 53201\, United States
CATEGORIES:Physics Colloquia
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