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X-WR-CALDESC:Events for Mathematical Sciences
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DTSTART;TZID=America/Chicago:20201023T140000
DTEND;TZID=America/Chicago:20201023T153000
DTSTAMP:20201031T174523
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SUMMARY:Colloquium: Dr. Harsh Jain
DESCRIPTION:Due to the COVID-19 Pandemic\, the University has instruction to cancel all in-person events through the Fall semester to adhere to city and state orders limiting public gatherings. Events still running must now take place Online— listed events will include a link in which one may access the Online webspace: \nTo view Dr. Jain’s talk\, enter his Online chatroom via Microsoft Teams— it will open at 2:00 pm on Friday\, October 23\, 2020. \nPractical Identifiability of Parameters: Two Sides of the Same Coin\nDr. Harsh Jain\nAssistant Professor of Mathematics & Statistics\nUniversity of Minnesota Duluth \n“Making quantitative predictions with data-driven models – such as in mathematical biology – often requires parameter estimation from imperfect data\, raising questions of parameter identifiability and estimability. In this talk\, I will first examine parameter identifiability using a case study of two compartmental\, ordinary differential equation models of cancer treatment with drugs that are cell cycle-specific (taxol) as well as non-specific (oxaliplatin). Despite the models being structurally identifiable\, I demonstrate how ignoring practical identifiability issues can lead to incorrect biological predictions. In the second half of my talk\, I will present a model of immunotherapy in the treatment of prostate cancer. Although several model parameters are practically unidentifiable\, I demonstrate how this unidentifiability can in fact be exploited to capture individual heterogeneity\, and offer an explanation for the very limited success of this kind of therapy in practice.” \n*Click to view the event flyer
URL:https://uwm.edu/math/event/colloquium-dr-harsh-jain/
CATEGORIES:Colloquia
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