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Colloquium: Dr. Harsh Jain

March 13 @ 2:00 pm - 3:30 pm

Free

Practical Identifiability of Parameters: A Tale with Two Endings

Dr. Harsh Jain
Florida State University
Assistant Professor

“Making quantitative predictions with data-driven models – such as in mathematical biology – often requires parameter estimation from imperfect data, raising questions of parameter identifiability and estimability. In this talk, I will first examine parameter identifiability using a case study of two compartmental, ordinary differential equation models of cancer treatment with drugs that are cell cycle-specific (taxol) as well as non-specific (oxaliplatin). Despite the models being structurally identifiable, I demonstrate how ignoring practical identifiability issues can lead to incorrect biological predictions. In the second half of my talk, I will present a model of immunotherapy in the treatment of prostate cancer. Although several model parameters are practically unidentifiable, I demonstrate how this unidentifiability can in fact be exploited to capture individual heterogeneity, and offer an explanation for the very limited success of this kind of therapy in practice.”

Light refreshments will be served @ 1:30 pm in EMS E424A.

Details

Date:
March 13
Time:
2:00 pm - 3:30 pm
Cost:
Free
Event Category:

Venue

EMS Building, Room E495
E495; 3200 N Cramer St.
Milwaukee, WI 53211 United States
Phone:
414-229-4836
Website:
www4.uwm.edu/letsci/math