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Colloquium: Dr. Harsh Jain

October 23 @ 2:00 pm - 3:30 pm

Due to the COVID-19 Pandemic, the University has instruction to cancel all in-person events through the Fall semester to adhere to city and state orders limiting public gatherings. Events still running must now take place Online— listed events will include a link in which one may access the Online webspace:

To view Dr. Jain’s talk, enter his Online chatroom via Microsoft Teams— it will open at 2:00 pm on Friday, October 23, 2020.

Practical Identifiability of Parameters: Two Sides of the Same Coin

Dr. Harsh Jain
Assistant Professor of Mathematics & Statistics
University of Minnesota Duluth

“Making quantitative predictions with data-driven models – such as in mathematical biology – often requires parameter estimation from imperfect data, raising questions of parameter identifiability and estimability. In this talk, I will first examine parameter identifiability using a case study of two compartmental, ordinary differential equation models of cancer treatment with drugs that are cell cycle-specific (taxol) as well as non-specific (oxaliplatin). Despite the models being structurally identifiable, I demonstrate how ignoring practical identifiability issues can lead to incorrect biological predictions. In the second half of my talk, I will present a model of immunotherapy in the treatment of prostate cancer. Although several model parameters are practically unidentifiable, I demonstrate how this unidentifiability can in fact be exploited to capture individual heterogeneity, and offer an explanation for the very limited success of this kind of therapy in practice.”

*Click to view the event flyer

Details

Date:
October 23
Time:
2:00 pm - 3:30 pm
Event Category: