PhD, Michigan State University, Physiology
MS, Loyola University of Chicago, Biology
BS, Loyola University of Chicago
My research has focused upon the reproductive effects of estrogens (natural and environmental pollutants with estrogenic activity) and pollutants that modulate the estrogen-receptor signaling pathway (e.g., dioxins). Such molecules can inhibit ovarian function and fertility in several mammals, fish, and aquatic invertebrate species. The following is a more detailed synopsis of my research efforts.
Overall my interests lie in the area of control of development and atresia (apoptotic degeneration) of ovarian follicles in animals (invertebrates, fish, rats, hamsters, guinea pigs, primates). My laboratory evaluates effects of estrogens, follicle-stimulating hormone, growth factors, and most recently gold nanoparticles on the induction of atresia, studied in vivo and on follicle cells and oocytes in vitro; and the regulation of estrogen receptor function and fertility by endocrine-disrupting pollutants such as dioxins.
In a typical human menstrual cycle, one ovarian follicle (containing a healthy egg cell) from a cohort of a dozen or so goes on to ovulate, relegating the others to degeneration, or atresia by apoptosis. The primary focus of our laboratory is the elucidation of those factors involved in the regulation of ovarian follicle development (folliculogenesis), atresia, and ovulation in mammals. We are particularly intrigued in the role played by estrogens in this process. These biomedical models strongly suggest that there exits a complicated network of factors involved in overall regulation of folliculogenesis.
The various biomedical models that we use are applicable to humans, but possess the advantages of smaller size, ability to manipulate, genetics (e.g., zebrafish), direct extrapolation (non-human primates), and fewer ethical concerns. The biomedical goals of our studies are to determine the effects of neural and environmental molecules to which we are exposed on a daily basis on reproductive health and fertility in women; and to discern how these detrimental effects may be ameliorated, abolished or prevented.
Larson, Jeremy K., , Hutz, Reinhold J., and . “Reproductive nanotoxicology: current developments and future diretions.” Biology of Reproduction.
Hutz, Reinhold J. “Familiar and novel reproductive endocrine disruptors: xenoestrogens, dioxins and nanoparticles.” Current Trends in Endocrinology.
Liu, QIng, , , , , , Hutz, Reinhold J., and . “Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish.” PLoS One. (2014).
Larson, Jeremy K., , Hutz, Reinhold J., and . “Superovulation and ovulation induction.” The Encyclopedia of Human Biology. Ed. Abelson, , and Simon, . Elsevier, (2014).
Larson, Jeremy K., Carvan III, M. J., Teeguarden, J., Klaper, R., Watanabe, G., Taya, K., Krystofiak, E., and Hutz, Reinhold J. “Low-dose gold nanoparticles exert subtle endocrine-modulating effects on rat ovarian steroidogenesis ex vivo is independent of oxidative stress.”Nanotoxicology 8.8 (2014): 856-866.
Larson, Jeremy, Carvan, Michael, and Hutz, Reinhold. Engineered nanomaterials: an emerging class of novel endocrine disruptors. 91. Ed. Hutz, Reinhold J. 2014.
Liu, Qing, Basu, N., Goetz, G., Jiang, G., Hutz, Reinhold J., Tonellato, P. J., and Carvan III, M. J. “Differential gene expression associated with dietary methylmercury exposure in rainbow trout and zebrafish.” Ecotoxicology 22. (2013): 740-751.
Liu, Qing, Rise, M. L., Struble, C. A., Spitsbergen, J. M., McGraw, J. E., Goetz, G., Larson, J. K., Hori, T. S., Hutz, Reinhold J., and Carvan III, M. J. “Gene expression and pathologic alterations in juvenile rainbow trout due to chronic dietary TCDD exposure.” Aquatic Toxicology 15.140-141 (2013): 356-368.
Huang, P., Zhou, Z., Wang, H., Wei, Q., Zhang, L., Zhou, X, Hutz, Reinhold J., Mao, D., and Shi, F. X. “Effect of the IGF- 1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion.” Int’l J Molec Med 30. (2012): 650-658.
Hutz, Reinhold J. “Current status of potential bisphenol toxicity in dentistry.” General Dentistry 59. (2011): 262-265.
Wang, W., Lui, H. J., Ding, W., Gong, Y., Chen, J., Hutz, Reinhold J., Mao, D., and Shi, F.“Reproductive toxicity of acrylamide-treated male rats.” Reproductive Toxicology 29. (2010): 225-230.
Wang, W., Liu, H., Ding, W., Gong, Y., Chen, J., Hutz, Reinhold J., Mao, D., and Shi, F. X.“Involvement of cell proliferation in the process of follicular atresia in the guinea pig.” Tissue and Cell 42. (2010): 234-241.
Stelzer, Rose V., and Hutz, Reinhold J. “Gold nanoparticles enter rat ovarian granulosa cells and subcellular organelles, and alter in-vitro estrogen accumulation.” Journal of Reproduction and Development 55. (2009): 685-690.