Mahsa Ranji, Ph.D.

Associate Professor
Electrical Engineering

Founder and Director of the Biophotonics Lab

Professor Ranji has openings for motivated graduate students with strong background in optics, biomedical optics and interested in hands-on experiments for medical applications. Please send your CV and a brief description of background and research interests by email.

Education:

  • Ph.D., Electrical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, 2007.
  • M.Sc., Electrical Engineering, Khajeh Nasir Toosi University of Technology, Tehran, Iran, 2000.
  • B.Sc., Electrical Engineering, Sharif University of Technology, Tehran, Iran, 1998.

Research Focus:

  • Biophotonics
  • Bio-instrumentation
  • Noninvasive optical tissue diagnostics
  • Image processing
  • Fluorescence imaging/microscopy

Patent

  • J.H. Gorman, R.C. Gorman, M. Ranji, “In vivo Measurement of Mitochondrial Function,” US patent 8473036.

Publications

[1] P. Kadamati, J.J. Sugar, B.J. Quirk, S. Mehrvar, G.G. Chelimsky, H.T. Whelan, T.C. Chelimsky, M. Ranji, “Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome,” Journal of Innovative Optical Health Sciences (JIOHS), July 2018.

[2] Z. Ghanian, S. Mehrvar, N. Jamali, C.M. Sorenson, N.Sheibani, M. Ranji, “Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition,” Journal of Biophotonics, doi: 10.1002/jbio.201700289, March 2018.

[3] Mette Funding la Cour, S. Mehrvar, J. Heisner, M. Masoudi Motlagh, M. Medhora, M. Ranji, A. Camara, “Optical imaging of whole thorax irradiated rat hearts exposed to ischemia-reperfusion injury,” JBO, Vol. 23, No 1, DOI: 10.1117/1.JBO.23.1.016011, Jan 2018.

[4] M. Funding la Cour, S. Mehrvar, J. Kim, M. Zimmerman, J. Hong, M. Ranji, “Optical imaging for the assessment of hepatocyte metabolic state in ischemia and reperfusion injuries,” Journal of Biomedical Optics Express, Vol. 8, No. 10, September 2017.

[5] Z. Ghanian, G.G. Konduri, S.H. Audi, Amadou K.S. Camara and M. Ranji, “Quantitative optical measurement of mitochondrial superoxide dynamics in pulmonary artery endothelial cells,” Journal of Innovative Optical Health Sciences (JIOHS), Vol. 11, No. 1, June 2017.

[6] E. Aboualizadeh, M. Ranji, C.M. Sorenson, R. Sepehr, N. Sheibani, C. Hirschmugl, “Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging: Towards diabetes Pathogenesis,” Analyst, Feb. 2017.

[7] M. Ranji, M. MasoudiMotlagh, F. Salehpour, R. Sepehr, J.S. Heisner, R.K. Dash, A.K.S. Camara, “Optical Cryoimaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and its Alteration during Ischemia and Reperfusion,” IEEE Journal of Translational Engineering in Health and Medicine (JTEHM), Vol. 4, July 2016. (Featured on IEEE EMBS website)

[8] Zahra Ghanian, K. Staniszewski, N. Jamali, R. Sepehr, S. Wang, C.M. Sorenson, N.Sheibani, M. Ranji, “Quantitative Assessment of Retinopathy Using Multi parameter Image Analysis,” Journal of Medical Signals and Sensors, DOI: 10.1109/JTEHM.2016.2570219,Vol. 6, No.2, April 2016.

[9] S.H. Audi, A.V. Clough, S.T. Haworth, M. Medhora, M. Ranji, J.C. Densmore, E.R. Jacobs, “99mTc-Hexamethylpropyleneamine Oxime Imaging for Early Detection of Acute Lung Injury in Rats Exposed to Hyperoxia or Lipopolysaccharide Treatment,” Shock, DOI: 10.1097/SHK.0000000000000605, March 2016.

[10]A.W. Cowley, Jr., C. Yang, N. Zheleznova, A. Staruschenko, T. Kurth, K. Sadovnikov, A. Dayton, M. Hoffman, R. Ryan,M. Skelton, F. Salehpour, M. Ranji, and A. Geurts, “Evidence of the Importance of NOX4 in the Production of Hypertension in Dahl Salt-Sensitive Rats,” Hypertension, DOI:10.1161/HYPERTENSIONAHA.115.06.280, Dec. 2015.

[11] M. MasoudiMotlagh, M. Azimipour, J. Sugar, W.W Linz, G. Michalak, N. Seo, and M. Ranji, “Monitoring hemodynamic changes in stroke-affected muscles using near-infrared spectroscopy,” Journal of Rehabilitation and Assistive Technologies Engineering, Vol. 1, DOI: 10.1177/2055668315614195, Dec. 2015.

[12] F. Salehpour, Z. Ghanian, C. Yang, N.N. Zheleznova, T. Kurth, R. Dash, A.W. Jr Cowley, M. Ranji, “Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: Optical fluorescence 3D cryoimaging,” American Journal of Physiology Renal (AJP Rental), Vol. 309, No. 4, F377-F382, DOI: 10.1152/ajprenal.00098.2015, Aug. 2015.

[13] M. MasoudiMotlagh, R. Sepehr, N. Sheibani, C.M. Sorenson, and M. Ranji, “Optical cryoimaging of mitochondrial redox state in Bronchopulmonary-dysplasia injury models in mice lungs,” Quantitative Imaging in Medicine and Surgery, Vol. 5, No.1, Feb. 2015.

[14] Z. Ghanian, A.G. Eis. G.K. Konduri, and M. Ranji, “Optical studies of oxidative stress in pulmonary artery endothelial cells," SPIE BIOS, San Francisco, Feb. 2015.

[15] F. Salehpour, C. Yang, T. Kurth, A. W. Cowley Jr, and M. Ranji, “Optical cryoimaging of rat kidney and the protective effect of p67 in salt-induced hypertension," SPIE BIOS, San Francisco, Feb. 2015.

[16] A. W. Cowley Jr., F. Salehpour, C. Yang, T. Kurth, M. Ranji, “Cryofluorescence 3D imaging shows mutation p67phox improves metabolic function and reduces oxidative stress in the renal medulla of Dahl salt-sensitive rats," American Heart Association Conference, High Blood Pressure Research, San Francisco, CA, Sept. 2014.

[17] T. R. Schaid A. H. Abdelhafeez, M. Ranji, R. Love, S. Audi, S. Kaul, F. Bashiri, E. MasoudiMotlagh, F. Salehpoor, E. Jacobs, J. C. Densmore, “Surface Fluorescence Studies Of Tissue Mitochondrial Redox State In Ex-vivo Lung Perfusion,"Shock 37th annual Conference, June 2014.

[18] Z. Ghanian, K. Staniszewski, R. Sepehr, C.M. Sorenson, N. Sheibani, and M. Ranji, “Cytometric classification of retinopathic injury," SPIE Proceeding of SPIE BIOS, San Francisco, Feb. 2014.

[19] W.W. Linz, G. Michalak, M.M. Motlagh, N. Seo, M. Ranji, “Blood volume and oxygenation changes in the skeletal muscles of stroke patients measured using non-invasive surface near-infrared spectroscopy," SPIE Proceeding of SPIE BIOS, San Francisco, Feb. 2014.

[20] Z. Ghanian, S. Maleki, F. Assadi-Porter and M. Ranji, “Optical imaging of mitochondrial redox state in rodent models with 3-iodothyronamine,” Journal of Experimental Medicine and Biology, Vol. 239, pp. 151- 158, DOI: 10.1002/jbio.201300033, Dec. 2013.

[21] Z. Ghanian, S. Maleki, F. Assadi-Porter and M. Ranji,   ” Optical imaging of mitochondrial redox state in rodent models with 3-iodothyronamine,” Journal of Experimental Medicine and Biology, Vol. 239, pp. 151- 158, DOI 10.1002/jbio.201300033, Dec. 2013.

[22] R. Sepehr, S. Audi, K. Staniszewski, E. R. Jacobs, and M. Ranji,   “Novel Flurometric Tool to Assess Mitochondrial Redox State of Isolated Perfused Rat Lungs after Exposure to Hyperoxia," IEEE Journal of Translational Engineering in Health and Medicine, Vol. 1, No. 1, 1500210-1_1500210-10, Nov. 2013.

[23] Z. Ghanian, M. MasoudiMotlagh, S. Maleki, Z. Bolandnazar, F. Assadi-Porter, M. Ranji,   ” Optical Redox Imaging of Metabolic Dysfunction in Polycystic Ovary Syndrome,” BMES Annual conference, Seattle, Sept. 2013.

[24] Z. Ghanian, S. Maleki, C.M. Sorenson, SunYoung Park, N. Sheibani and M. Ranji,   “Organ specific optical imaging of mitochondrial redox state in a rodent model of hereditary hemorrhagic telangiectasia-1,” Journal of Biophotonics, Vol. 6, No. 6, June 2013.

[25] R. Sepehr, S. Audi, S. Maleki, A.L. Eis, G.G. Konduri, M. Ranji,   “Optical Imaging of Lipopolysaccharide-induced Oxidative Stress in Acute Lung Injury from Hyperoxia and Sepsis,” Journal of Innovative Optical Health Sciences (JIOHS), Vol. 6, No.3 June 2013.

[26] W. Linz, G. Michalak, M. MasoudiMotlagh, N. Seo, M. Ranji,  “Hand function assessment of stroke patients using non-invasive surface near-infrared spectroscopy,” Great Lake Biomedical Conference, GE Healthcare, Milwaukee, April 2013 (awarded third place).

[27] M. MasoudiMotlagh, S. Maleki, F. Assadi-Porter, M. Ranji,  “Optical Redox Imaging to Monitor Metabolic Dysfunction in Polycystic Ovary Syndrome,” 2013 Great Lake Biomedical Conference, GE healthcare, Milwaukee, April 2013.

[28] Z. Ghanian, S. Maleki, C.M. Sorenson, N. Sheibani, M. Ranji,  “Optical Imaging of Cellular Redox State Related to Retinopathy Dysfunction in Endoglin Heterozygous (Eng+/-) Mice,” UWM CEAS Research Day, April 2013.

[29] R. Sepehr, K. Staniszewski, E. R. Jacobs, S. Audi, and M. Ranji, “Fluorometry of ischemia reperfused rat lungs in vivo.”Proceeding of SPIE BIOS, San Francisco, Jan. 2013.

[30] Z. Ghanian, S. Maleki, S. Gopalakrishnan, R. Sepehr, J. T. Eells and M. Ranji, “Optical imaging of oxidative stress in rodent model of retinitis pigmentosa.” Proceeding of SPIE BIOS, San Francisco, Jan. 2013.

[31] Sepideh Maleki, Sandeep Gopalakrishnan, Reyhaneh Sepehr, Zahra Ghanian, Heather Schmitt, Janis Eells, Mahsa Ranji, “Optical imaging of tissue mitochondrial redox state in rodent model of retinitis pigmentosa.” Journal of Biomedical Optics, Vol. 18, No. 1, Jan 2013.(Selected as cover page).

[32] Kevin Staniszewski, Said H. Audi, Reyhaneh Sepehr, Elizabeth R. Jacobs, and Mahsa Ranji, “Surface Fluorescence Studies of Tissue Mitochondrial Redox State in Isolated Perfused Rat Lungs.” Annals of Biomedical Engineering, Vol. 41, Jan. 2013.