Ph.D., Dartmouth College, 1989
The primary focus of our work is on understanding the neural systems underlying complex psychological phenomena like learning, memory, and emotion. We are interested in how memory is stored in the brain, how experience and learning can modify the nervous system, and how brain systems work together to solve these problems. While the emphasis in my lab is on basic science rather than on neuropathology or mental disorders, some of the fundamental questions we're addressing can relate to clinical problems. We take a multi-level approach which includes molecular neurobiology, functional brain imaging, and behavioral studies in humans and laboratory animals.
Research projects currently underway include:
- Studies on the molecular mechanisms involved in long-term memory formation with a focus on neuronal protein synthesis and degradation.
- Examining some of the neurobiological mechanisms through which motivation and emotion can influence learning and perception.
- Circuit analysis of fear learning focused on interactions between the amygdala, hippocampus and prefrontal cortex.
- Functional mapping of brain circuits important for implicit and explicit memory performance using functional magnetic resonance imaging (fMRI) in human volunteers. The role of awareness and consciousness in learning.
I am currently interested in taking new Ph.D. students and postdocs. Federally funded RA positions are available to qualified students. Please feel free to contact me or visit our web site for further details.
Psych 254: Physiological Psychology
Psych 355: Introduction to Neuroscience II: From Brain to Behavior
Psych 657: Neurobiology of Learning and Memory
Psych 754: Proseminar in Biological Psychology
Psych 954: Gene Expression and Behavior
Izumi, H., Kawahata, I., Shinoda, Y., Helmstetter, F. J., & Fukunaga, K. (2020). SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Dulka, B. N., Pullins, S. E., Cullen, P. K., Moyer, J. R., & Helmstetter, F. J. (2020, July (3rd Quarter/Summer)). Age-related memory deficits are associated with changes in protein degradation in brain regions critical for trace fear conditioning. Neurobiology of aging
Ferrara, N. C., Jarome, T. J., Cullen, P. K., Orsi, S. A., Kwapis, J. L., Trask, S., Pullins, S. E., & Helmstetter, F. J. (2019). GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating. SCIENTIFIC REPORTS
De La Rosa, Israel J., Azimipour, M., Cullen, P. K., Helmstetter, F. J., & Pashaie, R. (2018). Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber. INTERNATIONAL JOURNAL OF OPTICS
Belleau, E. L., Pedersen, W. S., Miskovich, T. A., Helmstetter, F. J., & Larson, C. L. (2018). Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
Azimipour, M., Sheikhzadeh, M., Baumgartner, R., Cullen, P. K., Helmstetter, F. J., Chang, W., & Pashaie, R. (2017). Fluorescence laminar optical tomography for brain imaging: system implementation and performance evaluation. JOURNAL OF BIOMEDICAL OPTICS
Ferrara, N. C., Cullen, P. K., Pullins, S. P., Rotondo, E. K., & Helmstetter, F. J. (2017). Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination. LEARNING & MEMORY