Yuan, Nina
Year of Graduation: 2016
Research Lab: Professor Alexander Leggy Arnold
Major Area of Focus: Biochemistry
Minor Area of Focus: High-Throughput Screening
Publications:
Gloria S. Forkuo, Amanda N. Nieman, Nina Y. Yuan, Revathi Kodali, Olivia B. Yu, Nicolas M. Zahn, Rajwana Jahan, Guanguan Li, Michael Rajesh Stephen, Margaret L. Guthrie, Michael M. Poe, Benjamin D. Hartzler, Ted W. Harris, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook and Leggy A. Arnold “Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators” Molecular Pharmaceutics 2017. 14, 2088-2098.
Rajwana Jahan, Michael R. Stephen, Gloria S. Forkuo, Revathi Kodali, Margaret L. Guthrie, Amanda N. Nieman, Nina Y. Yuan, Nicolas M. Zahn, Michael M. Poe, Guanguan Li, Olivia B. Yu, Gene T. Yocum, Charles W. Emala, Douglas C. Stafford, James M. Cook, and Leggy A. Arnold "Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments" European Journal of Medicinal Chemistry 2017, 126, 550-560.
Nina Y. Yuan, Michael M. Poe, Christopher Witzigmann, James M. Cook, Douglas C. Stafford, Leggy A. Arnold “Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells” Journal of Pharmacological and Toxicological Methods 2016, 82, 109-114.
Gloria S. Forkuo, Margaret L. Guthrie, Nina Y. Yuan, Amanda N. Nieman, Revathi Kodali, Rajwana Jahan, Michael R. Stephen, Gene T. Yocum, Marco Treven, Michael M. Poe, Guanguan Li, Olivia B. Yu, Benjamin D. Hartzler, Nicolas M. Zahn, Margot Ernst, Charles W. Emala, Douglas C. Stafford, James M. Cook, and Leggy A. Arnold “Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments” Molecular Pharmaceutics 2016, 13, 2026-2038.
Margaret L Guthrie, Preetpal S. Sidhu, Emily K. Hill, Timothy C. Horan, Premchendar Nandhikonda, Kelly A. Teske, Nina Y. Yuan, Marino Sidorko, Revathi Kodali, James M. Cook, Lanlan Han, Nicholas R. Silvaggi, Daniel D. Bikle, Richard G. Moore, Rakesh K. Singh, and Leggy A. Arnold “Antitumor activity of 3-Indolylmethanamines 31B and PS121912” Anticancer Research 2015, 35(11), 6001-6007.
Anticancer Activity of VDR-coregulator inhibitor PS121912 Sidhu, P. S.; Teske, K.; Feleke, B.; Yuan, N. Y.; Guthrie, M. L.; Fernstrum, G. B.; Vyas, N. D.; Han, L.; Preston, J.; Bogart, J. W.; Silvaggi, N. R.; Cook, J. M.; Singh, R. K.; Bikle, D. D.; Arnold, L. A.,. Cancer Chemother Pharmacol 2014.
Identification of VDR Antagonists Among Nuclear Receptor Ligands Using Virtual Screening. Teske, K.; Nanhikonda, P.; Bogart, J. W.; Feleke, B.; Sidhu, P.; Yuan, N. Y.; Preston, J.; Goy, R.; Han, L.; Silvaggi, N. R.; Singh, R. K.; Bikle, D. D.; Cook, J. M.; Arnold, L. A., Nuclear Receptor Research 2014, 1, 1-8.
Modulation of Transcription Mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ. Teske, K.; Nandhikonda, P.; Bogart, J. W.; Feleke, B.; Sidhu, P.; Yuan, N.Y.; Preston, J.; Goy, R.; Arnold, L. A.,. Biomolecular Research & Therapeutics 2014, 3 (1).
Development of Novel Vitamin D Receptor-Coactivator Inhibitors. Sidhu, P. S.; Nassif, N.; McCallum, M. M.; Teske, K.; Feleke, B. D.; Yuan, N. Y.; Nandhikonda, P.; Cook, J. M.; Singh, R. K.; Bikle, D. D.; Arnold, L. A., ACS Medicinal Chemistry Letters 2014, 5 (2), 199-204.
Peroxisome Proliferation- Activated Receptor Agonist GW0742 Interacts Weakly with Multiple Nuclear Receptors, Including the Vitamin D Receptor. Nandhikonda, P.; Yasgar, A.; Baranowski, A.; Sidhu, P. S.; McCallum, M. M.; Pawlak, A. J.; Teske, K.; Feleke, B.; Yuan, N. Y.; Kevin, C.; Bikle, D. D.; Ayers, S. D.; Webb, P.; Rai, G.; Simeonov, A.; Jadhav, A.; Maloney, D.; Arnold, L. A., Biochemistry 2013, 52, 4193-4203.
Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system. Qin Chen, Peter D. Yim, Nina Yuan, Juliette Johnson, James M Cook, Steve Smith, Cristian Ionescu-Zanetti, Zhi-Jian Wang, Leggy A. Arnold, Charles W. Emala. Assay Drug Dev Technol, 2012. 10(4): p. 325-35.
Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators. Premchendar Nandhikonda, Wen Z. Lynt, Megan M. McCallum, Tahniyath Ara, Athena M. Baranowski, Nina Y. Yuan, Dana Pearson, Daniel D. Bikle, R. Kiplin Guy, Leggy A. Arnold. J. Med. Chem. 2012, 55, 4640-51.
Transiently Transfected Cell Lines for GABA Receptor Screening. Nina Yuan. Application Note Fluxion Biosciences, 2011.