Roni, Md Shadiqur Rashid

PhD
Chemistry & Biochemistry

Year of Graduation: 2021
Research Lab: Prof. Alexander Arnold
Major Area of Focus: Analytical Chemistry/Mass spectrometry
Minor Area of Focus: Medicinal chemistry

Dissertation: Mass Spectrometry Directed Pre-Clinical Studies of Asthma Candidate MIDD0301 and Its Analogs

Publications:

Nicolas M. Zahn, Brandon N. Mikulsky, M. S. Rashid Roni, Gene T. Yocum, Md Yeunus Mian, Daniel E. Knutson, James M. Cook, Charles W. Emala, Douglas C. Stafford, and Leggy A. Arnold "Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models" ACS Pharmacology & Translational Science 2020, 3(6), 1381-1390.

Daniel E. Knutson, M.S. Rashid Roni, Md Yeunus Mian, James M. Cook, Douglas C. Stafford, and Leggy A. Arnold “Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301Organic Process Research & Development 2020, 24(8), 1467-1476.

M.S. Rashid Roni, Guanguan Li, Brandon N. Mikulsky, Daniel E. Knutson, Md Yeunus Mian, Nicolas M. Zahn, James M. Cook, Douglas C. Stafford and Leggy A. Arnold “The effects of pH on the structure and bioavailability of imidazobenzodiazepine-3-carboxylate MIDD0301Molecular Pharmaceutics 2020, 17(4), 1182-1192.

Nicolas M. Zahn, Alec T. Huber, Brandon Nicholas Mikulsky, Mae Elizabeth Stepanski, Alexander Scott Kehoe, Guanguan Li, Melissa Schussman, M.S. Rashid Roni, Revathi Kodali, James M. Cook, Douglas C. Stafford, Douglas A. Steeber and Leggy A. Arnold “MIDD0301 ‒ A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppressionBasic & Clinical Pharmacology & Toxicology 2019, 125, 75-84.

Gene T Yocum, Jose F Perez-Zoghbi, Jennifer Danielsson, Aisha S Kuforiji, Yi Zhang, Guanguan Li, M.S. Rashid Roni, Revathi Kodali, Douglas C Stafford, Leggy A. Arnold, James M Cook, Charles W Emala Sr “A Novel GABAA Receptor Ligand MIDD0301 with Limited Blood-Brain Barrier Penetration Relaxes Airway Smooth Muscle Ex Vivo and In VivoAmerican Journal of Physiology-Lung Cellular and Molecular Physiology 2018, 316, 385-390.

Gloria S. Forkuo, Amanda N. Nieman, Revathi Kodali, Nicolas M. Zahn, Guanguan Li, M.S. Rashid Roni, Michael Rajesh Stephen, Ted W. Harris, Rajwana Jahan, Margaret L. Guthrie, Olivia B. Yu, Janet L. Fisher, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook , and Leggy A. Arnold “A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA(A) Receptors in the LungMolecular Pharmaceutics 2018, 15, 1766-1777.