Gronert, Scott
sgronert@uwm.eduHolton Hall 218,

Gronert, Scott

Dean of the College of the Letters & Science, and Professor
Chemistry and Biochemistry

Education

BS, California State University, Long Beach, 1983
PhD, University of California, Berkeley, 1987
Postdoctoral, University of Colorado, 1987-90

Research interests

Gas-Phase Reaction Mechanisms

Although the great majority of organic chemistry is carried out in solution, the gas-phase provides many advantages in probing reaction mechanisms. First, it is possible to study reactions in a well-characterized, inert environment and probe intermediates that are too reactive to isolate or characterize in solution. Second, in the absence of solvation and ion pairing effects, it is possible to investigate the intrinsic reaction mechanism and confidently attribute reactivity trends to the characteristics of the reaction partners. Current projects focus on reactive intermediates in organometallic chemistry, C-H activation processes, and unusual mechanisms in nucleophilic aromatic substitution.

Recent Papers (since 2015)

Maclagan, R. G. A. R.; Gronert, S.; Meot-Ner (Mautner), M. “Protonated Polycyclic Aromatic Nitrogen Heterocyclics: Proton Affinities, Polarizabilities, and Atomic and Ring Charges of 1-5-Ring Ions”, J. Phys. Chem. A 2015, 119, 127-139.

Wiseman, A.; Sims, L. A.; Snead, R.; Gronert, S.; Maclagan, R. G. A. R.; Meot-Ner (Mautner), M. “Protonation Energies of 1-5-Ring Polycyclic Aromatic Nitrogen Heterocyclics: Comparing Experiment and Theory”, J. Phys. Chem. A, 2015, 119, 118-126.

Coskun, N; Cetin, M.; Gronert, S.; Ma, J. X.; Erden, I. “Pyrrolidine catalyzed reactions of cyclopentadiene with alpha,beta-unsaturated carbonyl compounds.: 1,2-versus 1,4-additions”, Tetrahedron, 2015, 71, 2636-2642.

Swift, C. A.; Gronert, S. “Intermolecular C-H Bond Activation by a Cationic Iridium(III) Dichloride Phenanthroline Complex”, Angew. Chem. Int. Ed., 2015, 54, 6475-6478.

Aldajaei, J. T. Keeffe, J. R.; Swift, C. A.; Gronert, S. “"Are Copper(I) Carbenes Capable Intermediates for Cyclopropanations? The Case for Ylide Intermediates”, Chem Eur. J 2015 21, 12702-12708.

Saunders, W. H.; Gronert, S. “The Competition Between Pathways in the Reactions of a Wide Variety of Bases with 2-Fluoro and 2-Chlorobutane in the Gas Phase”, J. Org. Chem., 2015, 80, 10787-10793.

Davis, M. C.; Gronert, S. “A Mass Spectrometric Method for Rapidly Assaying the Chiral Selectivities of the Copper(I) Complexes of C2-Symmetric Ligands”, J. Mass Spectrom., 2015, 50, 1279-1287.

Coffey, C. M.; Gronert, S. “A Cleavable Biotin Tagging Reagent that Enables the Enrichment and Identification of Carbonylation Sites in Proteins”, Anal. Bioanal. Chem. 2016, 408, 865-874

Derkits, D.; Wiseman, A.; Snead, R. F.; Dows, M.; Harge, J.; Lamp, J. A.; Gronert, S. “Development and Evaluation of a Variable-Temperature Ion Trap Mass Spectrometer”, J. Am. Soc. Mass Spectrom. 2016, 27, 339-343.

Erden, I.; Basada, J.; Poli, D.; Cabrera, G.; Xu, F.; Gronert, S. “Unusual Hydroxyl Effect on Fulvene Endoperoxide Decompositions”, Tetrahedron Lett., 2016, 57, 2190-2193.

Clarke, J.; Fowler, P. W.; Gronert, S.; Keeffe, J. “Effect of Ring Size and Migratory Groups on [1,n] Suprafacial Shift Reactions. Confirmation of Aromatic and Antiaromatic Transition-State Character by Ring-Current Analysis”, J. Org. Chem., 2016, 81, 8777-8788.

Swift, C. A.; Gronert, S. “The Gold(I)-Catalyzed Rearrangements of Propargyl Derivatives: A Gas-Phase Study”, Organometallics, 2016, 35, 3844-3851.
Ugur, Z.; Gronert, S. “A Robust Analytical Approach for the Identification of Specific Protein Carbonylation Sites: Metal-Catalyzed Oxidations of Human Serum Albumin”, Anal. Lett., 2017, 50, 557-569.

Parker, M.L., Gronert, S. “Investigating Reduced Metal Species via Sequential Ion/Ion and Ion/Molecule Reactions: The Reactions of Transition Metal Phenanthrolines with Allyl Iodide”, Int. J. Mass Spectrom., 2017, 418, 73-78.

Erden, I.; Gronert, S. Cabrera, G.; Coskun, N.; Tapken, M. “Diverse Modes of Reactivity of 6-(Chloromethyl)-6-methylfulvene”, Eur. J. Org. Chem. 2017, 20, 2925-2931.

Erden, I.; Gärtner, C.; Ma, J.; Cabrera, G.; Markham, K.; Azimi, S.; Gronert, S. ”Cyclopentadienones via a Tandem C-Cyclopropylnitrone Cyclization-Cycloreversion Sequence”, Eur. J. Org. Chem. 2017, 34, 5147-5153.

Eyilcim, O.; Issever, S.; Ocal, N.; Gronert, S.; Erden, I.” Imidazolidin-4-ones via (3+2) cycloadditions of aza-oxyallyl cations onto (E)-N-arylideneanilines”, Tetrahedron Lett. 2018, 59, 3674-3677.

Eyilcim, O.; Issever, S.; Ocal, N.; Gronert, S.; Erden, I. ”Imidazolidin-4-ones via (3+2) cycloadditions of aza-oxyallyl cations onto (E)-N-arylideneanilines”, Tetrahedron Lett. 2018, 59, 3674-3677.
Erden, I.; Gärtner, C.; Ma, J.; Cabrera, G.; Markham, K.; Azimi, S.; Gronert, S. ”Cyclopentadienones via a Tandem C-Cyclopropylnitrone Cyclization-Cycloreversion Sequence”, Eur. J. Org. Chem. 2017, 34, 5147-5153.
Erden, I.; Gronert, S. Cabrera, G.; Coskun, N.; Tapken, M. “Diverse Modes of Reactivity of 6-(Chloromethyl)-6-methylfulvene”, Eur. J. Org. Chem. 2017, 20, 2925-2931.
Parker, M.L., Gronert, S. “Investigating Reduced Metal Species via Sequential Ion/Ion and Ion/Molecule Reactions: The Reactions of Transition Metal Phenanthrolines with Allyl Iodide”, Int. J. Mass Spectrom., 2017, 418, 73-78.
Swift, C. A.; Gronert, S. “The Gold(I)-Catalyzed Rearrangements of Propargyl Derivatives: A Gas-Phase Study”, Organometallics, 2016, 35, 3844-3851. Ugur, Z.; Gronert, S. “A Robust Analytical Approach for the Identification of Specific Protein Carbonylation Sites: Metal-Catalyzed Oxidations of Human Serum Albumin”, Anal. Lett., 2017, 50, 557-569.
Erden, I.; Basada, J.; Poli, D.; Cabrera, G.; Xu, F.; Gronert, S. “Unusual Hydroxyl Effect on Fulvene Endoperoxide Decompositions”, Tetrahedron Lett., 2016, 57, 2190-2193.
Derkits, D.; Wiseman, A.; Snead, R. F.; Dows, M.; Harge, J.; Lamp, J. A.; Gronert, S. “Development and Evaluation of a Variable-Temperature Ion Trap Mass Spectrometer”, J. Am. Soc. Mass Spectrom. 2016, 27, 339-343.
Coffey, C. M.; Gronert, S. “A Cleavable Biotin Tagging Reagent that Enables the Enrichment and Identification of Carbonylation Sites in Proteins”, Anal. Bioanal. Chem. 2016, 408, 865-874
Davis, M. C.; Gronert, S. “A Mass Spectrometric Method for Rapidly Assaying the Chiral Selectivities of the Copper(I) Complexes of C2-Symmetric Ligands”, J. Mass Spectrom., 2015, 50, 1279-1287.
Saunders, W. H.; Gronert, S. “The Competition Between Pathways in the Reactions of a Wide Variety of Bases with 2-Fluoro and 2-Chlorobutane in the Gas Phase”, J. Org. Chem., 2015, 80, 10787-10793.
Aldajaei, J. T. Keeffe, J. R.; Swift, C. A.; Gronert, S. "Are Copper(I) Carbenes Capable Intermediates for Cyclopropanations? The Case for Ylide Intermediates”, Chem Eur. J 2015 21, 12702-12708.
Clarke, J.; Fowler, P. W.; Gronert, S.; Keeffe, J. “Effect of Ring Size and Migratory Groups on [1,n] Suprafacial Shift Reactions. Confirmation of Aromatic and Antiaromatic Transition-State Character by Ring-Current Analysis”, J. Org. Chem., 2016, 81, 8777-8788.
Swift, C. A.; Gronert, S. “Intermolecular C-H Bond Activation by a Cationic Iridium(III) Dichloride Phenanthroline Complex”, Angew. Chem. Int. Ed., 2015, 54, 6475-6478.
Coskun, N; Cetin, M.; Gronert, S.; Ma, J. X.; Erden, I. “Pyrrolidine catalyzed reactions of cyclopentadiene with alpha,beta-unsaturated carbonyl compounds.: 1,2-versus 1,4-additions”, Tetrahedron, 2015, 71, 2636-2642.
Wiseman, A.; Sims, L. A.; Snead, R.; Gronert, S.; Maclagan, R. G. A. R.; Meot-Ner (Mautner), M. “Protonation Energies of 1-5-Ring Polycyclic Aromatic Nitrogen Heterocyclics: Comparing Experiment and Theory”, J. Phys. Chem. A, 2015, 119, 118-126.
Maclagan, R. G. A. R.; Gronert, S.; Meot-Ner (Mautner), M. “Protonated Polycyclic Aromatic Nitrogen Heterocyclics: Proton Affinities, Polarizabilities, and Atomic and Ring Charges of 1-5-Ring Ions”, J. Phys. Chem. A 2015, 119, 127-139.