Ali, Taufeeque

Research lab:  Peng Group

Major area of focus: Biochemistry - Cancer Research

Minor area of focus: Medicinal Chemistry

Education: University of Wisconsin-Milwaukee, 2019-2024, Doctor of Philosophy in Chemistry; Milwaukee School of Engineering, 2011-2015, B.S. Biomolecular Engineering

Why I like chemistry: 

Before I developed an interest in biochemistry, my academic passion was mathematics. The precision, logic, and problem-solving aspects of mathematics fascinated me, and I thought my career path would be firmly rooted in numbers and formulas. However, during my Senior Design project in 2014-2015, my perspective began to shift. I was tasked with working on a project involving microalgae, and it was this experience that introduced me to the intricate world of biological pathways. The project opened my eyes to the beauty and complexity of biochemistry, where chemistry and biology intersect to unravel the mysteries of life. I found myself captivated by how chemical reactions within cells could dictate life processes, leading to a newfound love for chemistry. This transition from mathematics to biochemistry felt like a natural progression, as it allowed me to apply my analytical skills to the study of life at a molecular level.

Why I chose the program at UWM

When I decided to pursue a PhD, I knew I wanted to be part of a program that not only offered cutting-edge research opportunities but also nurtured entrepreneurial thinking and innovation. The Chemistry and Biochemistry program at UW-Milwaukee stood out to me for several reasons. First and foremost, Dr. Peng’s lab, renowned for its groundbreaking work in synthesizing anticancer drugs, perfectly aligned with my research interests and my ambition to translate scientific discoveries into real-world applications.

The opportunity to delve into how these drugs interact with cellular pathways and exert their effects was not only scientifically appealing but also opened the door to potential commercial applications. The program’s emphasis on interdisciplinary research, combined with access to state-of-the-art facilities, provided the ideal environment for me to develop both as a researcher and an innovator.

Moreover, UW-Milwaukee’s strong support for entrepreneurial initiatives made it clear that this was the place where I could cultivate my entrepreneurial skills. The supportive faculty and the vibrant research community have given me the confidence to think beyond the lab, envisioning how my research could lead to the development of new therapies or even the creation of a biotech startup. By being part of this program, I am not only challenging myself to excel academically but also preparing for a future where I can contribute to both science and industry.

Favorite things to do in Milwaukee

Milwaukee has become a second home to me, and there are several aspects of the city that I’ve come to love. One of my favorite things to do is explore the Milwaukee Riverwalk. The scenic views, especially during the fall, provide a perfect escape from the lab, allowing me to recharge and find inspiration.

Research goals

My primary research goal is to contribute to the development of more effective anticancer therapies by understanding how these drugs interact with cellular pathways at the molecular level. I am particularly interested in elucidating the mechanisms by which these drugs induce apoptosis in cancer cells. By leveraging my background in biochemistry and the expertise available at Dr. Peng’s lab, I aim to identify potential biomarkers for drug efficacy and resistance, which could pave the way for personalized cancer treatments. Ultimately, I hope my research will not only advance our understanding of cancer biology but also translate into tangible benefits for patients.

Publications

1. X. Peng, T. Ali. (2023). Novel Combination Therapy for Cancer Using Ros-Activated Prodrugs and Ros-Amplifying Therapeutics, US Provisional Patent Application No. 63/480,347, final patent application filed in Dec. 2023, Atty. File No. 020871-0011-WO01. U.S. Patent and Trademark Office.
2. H. Fan†, M. A. U. Zaman†, W. Chen†, T. Ali, A. Campbell, Q. Zhang, N. I. Setu, E. Saxon, N. M. Zahn, A. M. Benko, L. A. Arnold, and X. Peng. Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer, ACS Pharmacology & Translational Science 2021, 4 (2), 687-702.
3. Q. Zhang; T. Ali, Z Lin, X. Peng. Development of 4,4'-dibromobinaphthalene analogues with potent photo-inducible DNA cross-linking capability and cytotoxicity towards breast MDA-MB 468 cancer cells. Bioorg Chem. 2023, 140:106769
4. T. Ali, X. Peng. Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment, Cancers, 2024, 2024050194.
5. E. Saxon, T. Ali, X. Peng. Hydrogen Peroxide Responsive Theranostics for Cancer-Selective Activation of DNA Alkylators and Real-Time Fluorescence Monitoring in Living Cells, European Journal of Medicinal Chemistry, 2024, 116695.

Poster Presentations

1. T. Ali, X. Peng. “Reactive Oxygen Species (ROS) Activated Prodrugs: Mechanism and Combination Strategies.” Poster presented at the Department of Chemistry and Biochemistry Annual Research Symposium Spring 2024, University of Wisconsin Milwaukee, May 9-10th, 2024. 1st Place Graduate Poster Awards.
2. T, Ali. X. Peng. (2023, April 28). Reactive Oxygen Species (ROS) Activated Prodrugs: Mechanism and Combination Strategies. [Poster]. The Department of Chemistry and Biochemistry Annual Research Symposium Spring 2023, University of Wisconsin Milwaukee. 3rd Place Graduate Poster Awards.
3. T, Ali. X. Peng. (2023, March 26-28). Reactive Oxygen Species (ROS) Activated Prodrugs: Mechanism and Combination Strategies. [Poster]. American Chemical Society (ACS) Spring 2023, Indianapolis, IN
4. T, Ali. X. Peng. (2023, February 17). Reactive Oxygen Species (ROS) Activated Prodrugs: Mechanism and Combination Strategies. [Poster]. MIDD Symposium - University of Wisconsin Milwaukee
5. T, Ali. X. Peng. (2022, August 21-22). Reactive Oxygen Species (ROS) Activated Prodrugs: Mechanism and Combination Strategies. [Poster]. American Chemical Society (ACS) Fall 2022, Chicago, IL
6. T, Ali. X. Peng. (2022, April 22). Biological Investigation of (ROS) Activated Prodrugs: Mechanism of Function. [Poster]. The Department of Chemistry and Biochemistry Annual Research Symposium Spring 2022, University of Wisconsin Milwaukee

Awards

1. UWM Research Symposium 1st Place Poster Award (2024)
2. Research Assistantship (Fall 2023 - Spring 2024)
3. UWM Research Symposium 3rd Place Poster Award (2023)
4. Milwaukee Institute for Drug Discovery Research Assistant (Spring 2023)
5. Student Presenter at Wisconsin BioHealth Summit (October 2022)
6. UWM Teaching Assistant Mentor Award (2020 - 2022)
7. UWM Chancellor’s Award (2019 - 2022)
8. Graduate Student Travel Assistance Award, UWM Department of Chemistry & Biochemistry (2022)
9. National Institutes of Health (NIH) Grant (2023)
10. Catalyst Grant (2023)

Comments

Seminars
1. T, Ali. X. Peng. (2023, February 17). Reactive Oxygen Species (ROS) Activated Prodrugs: Mechanism and Combination Strategies. [Oral Presentation]. MIDD Symposium - University of Wisconsin Milwaukee
2. T, Ali. X. Peng. (2022, December 16). ROS-Activated DNA Alkylating Agents and Combination Strategies for Targeting Cancer. [Oral Presentation]. Chemistry Department - University of Wisconsin Milwaukee
3. T, Ali. X. Peng. (2022, October 12). ROS-Activated DNA Alkylating Agents and Combination Strategies for Targeting Cancer. [Oral Presentation]. BioForward Summit, Madison, Wisconsin. Top 10 contestant in Wisconsin.
4. T, Ali. X. Peng. (2020, October 10). Triple negative breast cancer: Molecular sub-types, Treatment, Challenges And Advances. [Seminar]. University of Wisconsin Milwaukee

Next Role: Postdoctoral Scholar at Northwestern Medicine - Feinberg School of Medicine, Chicago, IL

Suggestions:

For graduate students just starting out, embrace curiosity and persistence. Don’t be afraid to ask questions and seek guidance from mentors and peers. Focus on building a strong foundation in your field by thoroughly understanding the basics before diving into complex topics.
Time management is key—balance your coursework, research, and personal life effectively. Network with colleagues and attend seminars to stay informed about the latest developments in your area.
Finally, remember that setbacks are part of the learning process; resilience and adaptability will be your greatest assets as you navigate the challenges ahead.