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DTSTART;TZID=America/Chicago:20260206T150000
DTEND;TZID=America/Chicago:20260206T160000
DTSTAMP:20260530T000435
CREATED:20260129T231258Z
LAST-MODIFIED:20260130T221017Z
UID:10003969-1770390000-1770393600@uwm.edu
SUMMARY:Colloquium\, Prof. Jon-Marc Rodriguez\, UWM Chemistry
DESCRIPTION:Networking for Introverts (and Extroverts): Building Your Mentoring Network and Making the Most Out of Your Next Conference  \nNetworking is often framed as something that comes naturally to extroverts\, but building a strong professional network is a skill that can be developed intentionally by anyone. In this seminar\, we will discuss the role of mentors in supporting success at different stages of an academic or professional career and provide structured opportunities to reflect on existing relationships and areas where additional support may be helpful. The seminar will then shift to practical\, low-pressure strategies for networking at conferences\, including ways to prepare in advance\, engage during meetings\, and follow up effectively afterward.
URL:https://uwm.edu/chemistry/event/colloquium-prof-jon-marc-rodriguez-uwm-chemsitry/
LOCATION:Chemistry Lecture Hall 110\, 2000 E. Kenwood Boulevard\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquium
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DTSTART;TZID=America/Chicago:20260213T150000
DTEND;TZID=America/Chicago:20260213T160000
DTSTAMP:20260530T000435
CREATED:20260129T231753Z
LAST-MODIFIED:20260206T165814Z
UID:10003970-1770994800-1770998400@uwm.edu
SUMMARY:Colloquium\, Faija Akter\, UWM Chemistry
DESCRIPTION:Molybdenum Cofactor Deficiency: From Molecular Mechanisms to Clinical Breakthroughs\n\nMolybdenum cofactor (Moco) deficiency (MoCD) is a rare autosomal recessive disorder characterized by neonatal-onset myoclonic epileptic encephalopathy and dystonia\, with cerebral MRI changes resembling hypoxic–ischemic lesions. The molecular basis of the disease is the loss of sulfite oxidase (SOX) activity\, one of four Moco-dependent enzymes in humans. Accumulating toxic sulfite causes a secondary increase of metabolites such as S-sulfocysteine (SSC) and thiosulfate\, as well as a decrease in cysteine and its oxidized form\, cystine. These biochemical derangements trigger neurodegeneration through NMDA receptor-mediated excitotoxicity and ferroptosis resulting from glutathione depletion.\n\nMoco is synthesized by a three-step biosynthetic pathway involving the gene products of MOCS1\, MOCS2\, MOCS3\, and GPHN. Depending on which synthetic step is impaired\, MoCD is classified as type A\, B\, or C. This distinction is clinically relevant because the metabolic block in MoCD type A can be circumvented by administering cPMP\, marketed as fosdenopterin (Nulibry)\, which received FDA approval in 2021. Substitution therapy with cPMP is highly effective in reducing sulfite toxicity and restoring biochemical homeostasis\, while clinical outcome critically depends on the degree of brain injury prior to the start of treatment. Notably\, recent case studies reveal that brain injury begins prenatally between 22-28 weeks gestation\, underscoring the need for prenatal intervention strategies.\n\nIn the absence of specific treatments for MoCD type B/C and isolated SOX deficiency\, this presentation summarizes recent progress in understanding the underlying metabolic changes in cysteine homeostasis and explores novel therapeutic interventions — including dietary restriction\, NMDA receptor antagonists\, sulfite scavenging\, and ferroptosis inhibition to circumvent these pathological changes.
URL:https://uwm.edu/chemistry/event/colloquium-faija-akter-uwm-chemistry/
LOCATION:Chemistry Lecture Hall 110\, 2000 E. Kenwood Boulevard\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquium
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DTSTART;TZID=America/Chicago:20260220T150000
DTEND;TZID=America/Chicago:20260220T155000
DTSTAMP:20260530T000435
CREATED:20260202T170632Z
LAST-MODIFIED:20260211T201904Z
UID:10003971-1771599600-1771602600@uwm.edu
SUMMARY:Guest Speaker\, Joceyln Nardo\, Ph.D.\, Ohio State University
DESCRIPTION:Catalysts for Change: Cultivating a Culture for Chemistry Graduate Student Success \nThis project investigates how departmental culture shapes chemistry graduate students’ belonging\, development\, and access to opportunity. The project responds to documented challenges in doctoral education including unclear success criteria\, inconsistent mentoring\, and hidden cultural norms and seeks to generate actionable\, evidence-based pathways for systemic improvement. We designed and deployed a mixed-methods pilot survey to chemistry graduate students measuring six domains informed by prior graduate-education and equity scholarship: (1) graduate milestones\, (2) research competency\, (3) teaching competency\, (4) advisor support (academic and emotional)\, (5) peer and departmental culture\, and (6) academic and demographic background. This talk will center on the qualitative data which is founded on academic citizenship\, which is a set of behaviors\, responsibilities\, and relational practices through which members of an academic community contribute to its collective functioning\, integrity\, and well-being beyond their individual scholarly outputs. It includes activities such as mentoring\, service\, collaboration\, care work\, and stewardship that sustain learning environments\, support colleagues and students\, and advance the shared mission of the institution and discipline. Findings show that academic citizenship is unevenly distributed across student groups and is most strongly predicted by research competency and access to departmental resources. Advisor emotional support and advisor skill dynamics emerged as significant contributors to academic citizenship. Results informed department-level interventions\, including (1) a redesigned first-year experience course integrating research\, teaching\, communication\, and wellness\, and (2) a multidimensional mentoring model grounded in sociopolitical noticing and disciplinary metaphors (chemist\, family\, coach). The project demonstrates that departmental culture can be surfaced\, measured\, and intentionally reshaped to create conditions where graduate students thrive because of rather than in spite of our systems.
URL:https://uwm.edu/chemistry/event/guest-speaker-joceyln-nardo/
LOCATION:Chemistry Lecture Hall 110\, 2000 E. Kenwood Boulevard\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquium
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