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Chemistry & Biochemistry Colloquium – Yeunus Mian – Cook Research Group – Targeting HIV’s Weak Point: Blocking the virus at the cell entrance

February 23, 2018 @ 3:00 pm - 4:00 pm

Abstract

Human Immunodeficiency Virus (HIV) is a retrovirus that targets the CD4 receptor (CD4R) of T-lymphocytes. Once infected, T cells are compromised and will be unable to mediate the immune response. The depletion of T cells increases the chance of opportunistic infections by other viruses and bacteria, taking advantage of the weak immune system. One potential approach to intervene the acquired immunodeficiency syndrome (AIDS) pandemic includes the inhibition of viral entry. HIV interacts with the CD4 receptor of T cells using an extracellular membrane protein GP120. This interaction initiates a series of coordinated events that influences binding to a chemokine co-receptor CCR5. Small molecule inhibitors have been developed to target an interfacial cavity known as the ‘Phe43’ cavity, which is formed by the CD4R–GP120 interaction. Improved inhibitors have been discovered based on structure-activity relationship studies in conjunction with thermodynamic analysis of hotspot binding between viral GP120 and the T-cell CD4R.

 

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Details

Date:
February 23, 2018
Time:
3:00 pm - 4:00 pm

Venue

Chemistry Room 190
3210 N. Cramer Street
Milwaukee, 53211
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