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CREATED:20250923T153304Z
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SUMMARY:Biological Sciences Colloquium: Dr. Shan He
DESCRIPTION:Shan He\, Ph.D.\, Assistant Professor\, Department of Botany\, University of Wisconsin – Madison\, will present a talk about her work entitled\, ‘Structure and regulation of the CO2-concentrating organelle\, the pyrenoid’ \nThe Abstract is as Follows: \nApproximately one-third of global CO2 fixation occurs in an algal organelle\, the pyrenoid. Engineering the pyrenoid into crops has great potential to increase yields. The pyrenoid enhances photosynthesis by clustering the CO2-fixing enzyme Rubisco into a dynamic liquid-like condensate and supplying it with concentrated CO2. A molecular understanding of pyrenoid biogenesis and regulation will facilitate the engineering of the pyrenoid and shed light on how the pyrenoid plays such an important role in the global carbon cycle. However\, both the structural basis of the pyrenoid condensate and how its phase separation is regulated were unknown. In my talk\, I will share our structural characterization of how the pyrenoid condensate is formed by a linker protein that clusters multiple Rubisco holoenzymes\, which reveals a critical motif that mediates the assembly of the pyrenoid’s three sub-compartments. Furthermore\, I will discuss our discovery and characterization of a protein kinase that regulates the size and number of the pyrenoid condensate through disrupting phase separation. Our findings advance the structural and regulatory understanding of the pyrenoid\, paving the way for its engineering into crops. More broadly\, our work makes the pyrenoid a powerful model for studying biological and biophysical mechanisms of biomolecular condensates in cell biology. \nThe presentation will begin at 3:00 PM in Lapham Hall N101\, preceded by an informal reception from 2:45 – 3:00PM.
URL:https://uwm.edu/biology/event/biological-sciences-colloquium-dr-shan-he/
LOCATION:Lapham Hall\, N101\, 3209 N Maryland Ave\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
ATTACH;FMTTYPE=image/jpeg:https://uwm.edu/biology/wp-content/uploads/sites/21/2025/09/Flyer-Shan-He-092625.jpg
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