BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Biological Sciences - ECPv6.17.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Biological Sciences
X-ORIGINAL-URL:https://uwm.edu/biology
X-WR-CALDESC:Events for Biological Sciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20230312T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20231105T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20240310T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20241103T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20250309T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20251102T070000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20240503T160000
DTEND;TZID=America/Chicago:20240503T170000
DTSTAMP:20240430T133814Z
CREATED:20240430T133814Z
LAST-MODIFIED:20240430T133814Z
UID:10001349-1714752000-1714755600@uwm.edu
SUMMARY:Biological Sciences Colloquium: Vidhya Basak
DESCRIPTION:Vidhya Basak\, UWM graduate student\, will present a talk about her work entitled\, “A New Level of Eukaryotic AMPK Regulation: Lessons From Yeast.” \nThe abstract is as follows: \nIn the Kuchin lab\, we focus on understanding the mechanisms by which eukaryotes respond to energy stress. Being able to respond to energy stress is quintessential for maintaining energy homeostasis. The AMP-activated protein kinase (AMPK) is the master regulator of energy homeostasis in eukaryotes from yeast to humans. Mammalian AMPK has been implicated in diseases from diabetes to cancer. AMPK of baker’s yeast (Saccharomyces cerevisiae) serves as an important model to understand eukaryotic AMPK signaling. Yeast AMPK responds to stresses caused by glucose/energy limitation and promotes utilization of alternative carbon sources. Like mammalian AMPK\, yeast AMPK is a heterotrimeric complex. It is composed of the catalytic α subunit (Snf1)\, one of three alternative targeting/scaffolding β subunits (Sip1\, Sip2\, or Gal83)\, and a regulatory γ subunit (Snf4). When energy levels drop\, yeast AMPK is known to be upregulated by two main mechanisms: 1) catalytic activation by phosphorylation of Thr210 of Snf1; 2) Gal83-dependent nuclear enrichment of the activated yeast AMPK complex. Here\, we present evidence for a new level of AMPK regulation. Thus far\, the AMPK complex has been assumed to assemble “by itself”. Our results suggest that yeast AMPK undergoes facilitated assembly aided by two paralogous WD40 repeat proteins. Our findings may have implications for AMPK regulation in other eukaryotes and inform research in human metabolic disease\, fungal pathogenesis\, and yeast biotechnology. \nThe presentation will begin at 4:00 PM in Lapham Hall N101\, preceded by an informal reception from 3:45 – 4:00PM.
URL:https://uwm.edu/biology/event/biological-sciences-colloquium-vidhya-basak/
LOCATION:Lapham Hall\, N101\, 3209 N Maryland Ave\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
X-TRIBE-STATUS:
GEO:43.0757204;-87.8840564
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Lapham Hall N101 3209 N Maryland Ave Milwaukee WI 53211 United States;X-APPLE-RADIUS=500;X-TITLE=3209 N Maryland Ave:geo:-87.8840564,43.0757204
END:VEVENT
END:VCALENDAR