BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Biological Sciences - ECPv6.17.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Biological Sciences
X-ORIGINAL-URL:https://uwm.edu/biology
X-WR-CALDESC:Events for Biological Sciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20230312T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20231105T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20240310T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20241103T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20250309T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20251102T070000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20240202T160000
DTEND;TZID=America/Chicago:20240202T170000
DTSTAMP:20240126T150935Z
CREATED:20240125T222241Z
LAST-MODIFIED:20240126T150935Z
UID:10001336-1706889600-1706893200@uwm.edu
SUMMARY:Biological Sciences Colloquium:  Dr. Alita Burmeister
DESCRIPTION:Title: Trade-offs and Trade-ups in Bacteria-Phage Coevolution \nAbstract: Evolutionary trade-offs are thought to be a fundamental factor constraining adaptation in natural populations. Trade-offs have also been leveraged in the treatment of bacterial infections through selection by phage at the expense of antibiotic resistance. However\, it is currently unknown how widespread and reliable such trade-offs may be. My group is using a combination of experimental evolution and molecular genetics to uncover when such tradeoffs may be in effect. We have discovered the potential for trade-offs between phage resistance and antibiotic resistance mediated by the lytic Escherichia coli phage U136B. We found that phage U136B adsorbs to TolC\, which is an outer membrane protein component of a multidrug efflux pump. Using experimental evolution\, we show that loss or modification of the tolC gene is a common evolutionary response to selection by phage U136B\, whereby some phage resistant mutants have reduced antibiotic resistance. However\, we also found that this trade-off strongly depended on the antibiotic\, type of selection experiment\, and the specific host resistance mutation. In some cases\, bacteria even evaded the trade-off such that phage-resistant mutants had the same or greater antibiotic resistance. In new work\, we are investigating alternative mutational pathways to phage resistance and the impact of host resistance on phage coevolution. Overall\, our results suggest that phage resistance may sometimes\, but not always\, help maintain antibiotic sensitivity in bacterial populations.
URL:https://uwm.edu/biology/event/biological-sciences-colloquium-dr-alita-burmeister/
LOCATION:Lapham Hall\, N101\, 3209 N Maryland Ave\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
X-TRIBE-STATUS:
GEO:43.0757204;-87.8840564
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Lapham Hall N101 3209 N Maryland Ave Milwaukee WI 53211 United States;X-APPLE-RADIUS=500;X-TITLE=3209 N Maryland Ave:geo:-87.8840564,43.0757204
END:VEVENT
END:VCALENDAR