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SUMMARY:Biological Sciences Colloquium: Xiaosa Jack Xu
DESCRIPTION:Dr. Xiaosa Jack Xu\, Professor of Plant Biology at University of California Davis\, will be presenting a talk about his work entitled “An Evolutionary View of Plant Inflorescence Development from Single-Cell and Spatial Profiling.”  The abstract is as follows: \nInflorescence architecture is a major determinant of reproductive success and crop yield\, yet how its developmental regulation evolves across phylogenetic scales remains incompletely understood. Here\, we integrate single-cell transcriptomics\, spatial gene expression\, and gene editing to examine inflorescence development across three hierarchical evolutionary levels: a deep comparison between monocots and eudicots\, a closer comparison within cereal monocots\, and a near-scale comparison between maize and its wild progenitor\, teosinte. \nAt the broadest scale\, we generated a comparative single-cell atlas of developing inflorescences in Arabidopsis and maize. This analysis recovered thousands of stem cells marked by CLAVATA3 and WUSCHEL and uncovered conserved stem cell regulators\, including members of the SERPINE1 mRNA-binding protein family\, revealing deeply conserved mechanisms underlying shoot meristem maintenance across monocots and eudicots. \nAt an intermediate scale\, we performed an integrative analysis of single-cell transcriptomes from developing inflorescences of five cereal crops: maize\, wheat\, barley\, rice\, and sorghum. We identified shared cell populations and resolved distinct meristem subdomains\, revealing a conserved core of meristematic cell identities and regulatory programs\, alongside divergence in transcriptional programs associated with lateral organ initiation and differentiation that likely underlie species-specific cereal inflorescence architectures. \nAt the closest scale\, we constructed a single-cell atlas of developing teosinte ears and compared it with maize to investigate domestication-associated changes in ear development. We identified cell-type-specific differentially expressed genes in inflorescence stem cells and axillary meristem-initiating cells\, many showing signatures of selection during domestication. Higher-order mutants in SPL\, UB2\, UB3\, TSH4\, and GLUTAREDOXIN genes reverted ear morphology toward teosinte-like forms. \nThe presentation will begin at 3:00 PM in Lapham Hall N101\, preceded by an informal reception from 2:45 – 3:00PM.
URL:https://uwm.edu/biology/event/biological-sciences-colloquium-xiaosa-jack-xu/
LOCATION:Lapham Hall\, N101\, 3209 N Maryland Ave\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
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DTSTART;TZID=America/Chicago:20260501T153000
DTEND;TZID=America/Chicago:20260501T163000
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CREATED:20260428T150201Z
LAST-MODIFIED:20260428T150418Z
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SUMMARY:Biological Sciences Colloquium: Chandika Rani Ganesh Babu
DESCRIPTION:Chandika Rani Ganesh Babu\, PhD candidate in the Latch Lab\, will be presenting a talk about her work entitled “Applied Genomics for White-tailed Deer Management: Population Monitoring and Chronic Wasting Disease.”  The abstract is as follows: \n\nChronic wasting disease (CWD) is a fatal neurological disease affecting deer and related species. As it continues to spread across North America\, it presents growing challenges for wildlife conservation and management. Understanding why some animals are more susceptible than others and developing better tools to monitor wild populations are critical steps toward effective disease control.  This talk will explore how genetics and genomic tools are advancing our understanding of white-tailed deer populations and the biological mechanisms underlying CWD susceptibility. Using large-scale\, range-wide sampling\, the talk will highlight how modern genomics can reveal patterns of population structure\, disease vulnerability\, and pathways that may shape future wildlife management strategies.  Join us to learn how genetics is helping address one of the most pressing disease challenges facing North American wildlife. \n\nPlease note that this week\, colloquium will be taking place at 3:30pm in the Union Alumni Fireside Lounge as the keynote talk of the 2026 Biological Sciences Research Symposium. 
URL:https://uwm.edu/biology/event/biological-sciences-colloquium-chandika-rani-ganesh-babu/
LOCATION:UWM Student Union Alumni Fireside Lounge\, 2200 E. Kenwood Blvd\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
ATTACH;FMTTYPE=image/jpeg:https://uwm.edu/biology/wp-content/uploads/sites/21/2026/04/Ganesh-Babu-2026.jpg
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DTSTART;TZID=America/Chicago:20260508T150000
DTEND;TZID=America/Chicago:20260508T160000
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CREATED:20260505T142946Z
LAST-MODIFIED:20260505T142946Z
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SUMMARY:Biological Sciences Colloquium: Dr. Daisy Sahoo
DESCRIPTION:Dr. Daisy Sahoo\, professor of biochemistry at Medical College of Wisconsin\, will be giving a talk about her work entitled “Receptor-mediated Approaches to Reducing Cardiovascular Risk.” The abstract is as follows: \nAtherosclerosis\, a major cause of cardiovascular disease (CVD)\, is an inflammatory disease resulting from the build-up of cholesterol in plaque along the artery walls. As such\, the development of strategies to lower plasma cholesterol levels remains a high priority.  While various lipid-lowering therapies designed to prevent cholesterol from accumulating in the blood have proved successful\, such treatments are sometimes accompanied by adverse side effects and residual CVD risk.  In this seminar\, we will discuss three different receptor-based approaches to reducing plasma cholesterol and CVD risk. At the level of the macrophage\, we will focus on the roles of CD36 (an oxidized LDL receptor) and free fatty acid receptor 4 (FFAR4) in the development of atherosclerosis.  We will also discuss SR-BI\, a receptor responsible for mediating HDL-cholesterol delivery to the liver for whole body cholesterol excretion. \nThe presentation will begin at 3:00 PM in Lapham Hall N101\, preceded by an informal reception from 2:45-3:00 PM.
URL:https://uwm.edu/biology/event/biological-sciences-colloquium-dr-daisy-sahoo/
LOCATION:Lapham Hall\, N101\, 3209 N Maryland Ave\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
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