Web Site: http://neuralcircuits.uwm.edu
Ph.D., Brown University 2002
Key Areas of Interests:
Sleep and Brain Rhythm
Optogenetic Dissection of Neuronal Circuits
Teaching and Research Interests:
We are interested in how different regions in the brain coordinate to encode, store, and transfer information.
The brain generates an assortment of neuronal oscillations that vary depending on the behavior and state of the animal, from active exploration to resting and different stages of sleep. Accordingly, in our recordings of large populations of spiking neurons we observe state-dependent temporal relationships at multiple timescales. What role do these unique spike patterns play and what do they tell us about the function of each brain state? To answer these and related questions, we combine behavioral studies of learning and exploring rats, multi-channel recordings of the simultaneous electrical (spiking) activity from hundreds of neurons during behavior and sleep, and optogenetics (based on virus-mediated light-activated ion channels and pumps) to excite and silence specific neural populations in precise time windows during learning, consolidation and recall.
We are currently looking for students with an interest in neurophysiology. Quantitative skills (statistics and signal processing), programming skills and appreciation of electronics are helpful; a desire to learn is essential.
Psych 954: Seminar in Physiological Psychology: Reactivation, Recall, and Memory Consolidation
Psych 933: Seminar in Neuroscience
Psych 210: Psychological Statistics
Taxidis, J., Anastassiou, C. A., Diba, K., & Koch, C. (2015, August). Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples. Neuron
Diba, K., Amarasingham, A., Mizuseki, K., & Buzsaki, G. (2014, November). Millisecond Timescale Synchrony among Hippocampal Neurons. Journal of Neuroscience
Mizuseki, K., Diba, K., Pastalkova, E., Teeters, J., Sirota, A., & Buzsaki, G. (2014, January (1st Quarter/Winter)). Neurosharing: large-scale data sets (spike, LFP) recorded from the hippocampal-entorhinal system in behaving rats. F1000Research
Gilmartin, M. R., Miyawaki, H., Helmstetter, F. J., & Diba, K. (2013, June). Prefrontal activity links nonoverlapping events in memory. Journal of Neuroscience
Grosmark, A. D., Mizuseki, K., Pastalkova, E., Diba, K., & Buzsaki, G. (2012, September). REM sleep reorganizes hippocampal excitability. Neuron
Mizuseki, K., Royer, S., Diba, K., & Buzsáki, G. (2012, August). Activity dynamics and behavioral correlates of CA3 and CA1 hippocampal pyramidal neurons. Hippocampus
Vandecasteele, M., S, Royer, S., Belluscio, M., Berenyi, A., Diba, K., Fujisawa, S., Grosmark, A., Mao, D., Mizuseki, K., Patel, J., Stark, E., Sullivan, D., Watson, B., & Buzsaki, G. (2012, March). Large-scale recording of neurons by movable silicon probes in behaving rodents. Journal of visualized experiments : JoVE
Vizuete, J. A., Pillay, S., Diba, K., Ropella, K. M., & Hudetz, A. G. (2012, October (4th Quarter/Autumn)). Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia. Frontiers in Integrative Neuroscience
Mizuseki, K., Diba, K., Pastalkova, E., & Buzsaki, G. (2011, August). Hippocampal CA1 pyramidal cells form functionally distinct sublayers. Nature Neuroscience, 14(9), 1174-81.
Sullivan, D., Csicsvari, J., Mizuseki, K., Montgomery, S., Diba, K., & Gyorgy, G. (2011, June). Relationships between Hippocampal Sharp Waves, Ripples, and Fast Gamma Oscillation: Influence of Dentate and Entorhinal Cortical Activity. Journal of Neuroscience, 31(23), 8605-8616.