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Peter Schwander

Professor & Graduate Academic Committee Chair
Physics
 KEN 3188
BiophysicsFaculty

Research

Professor Schwander’s research focuses on the structure and function of biological macromolecules by analyzing snapshots obtained by x-rays and electron microscopy.

He is also a participant in BioXFEL, a Science and Technology Center (STC) established by the National Science Foundation in 2013 of eight U.S. research universities aimed at addressing the fundamental questions in biology at the molecular level.

Research Interests

Structure and dynamics of macromolecular assemblies, molecular machines, single-particles methods using X-ray Free-Electron Laser and cryo-Electron Microscopy, data mining of large data sets by Manifold Embedding, Tomography.

Biographical Sketch

Peter Schwander graduated with his PhD in Physics from the Swiss Federal Institute of Technology Zürich (ETHZ), the most prestigious university in Switzerland, and completed postdoctoral studies at AT&T Bell Laboratories in New Jersey. Dr. Schwander returned to Switzerland after completing his postdoctoral work and then joined IHP, a Leibniz Institute for Microelectronics in Frankfurt (Oder), Germany before joining UWM as a Senior Scientist and Adjunct Professor. He worked in that capacity for six years before being promoted to Associate Professor in 2014.

In addition to his academic appoints, Dr. Schwander has served as the Vice President for Research and Development at Lesswire AG in Germany.

Selected Publications

Seitz, Evan, Acosta-Reyes, Francisco, Maji, Suvrajit, Schwander, Peter, and Frank, Joachim. “Recovery of Conformational Continuum from Single-particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth” IEEE Transaction on Computational Imaging8. (2022): 462-478.
Hosseinizadeh, achmad, Breckwold, N, Fung, Russell, Schmidt, Marius, Schwander, Peter, Santra, R., and Ourmazd, Abbas. “Single-femtosecond atomic-resolution observation of a protein traversing a conical intersection” Nature(2021).
Cruz-Chu, Eduardo R., Hosseinizadeh, Ahmad, Mashayekhi, Ghoncheh, Fung, Russell, Ourmazd, Abbas, and Schwander, Peter. “Selecting XFEL single-particle snapshots by geometric machine learning” Structural Dynamics8.1 (2021).
Assalauova, D, Kim, Y Y., Bobkov, S, Khubbutdinov, R, Rose, M, Alvarez, R, Andreasson, J, Balaur, E, Contreras, A, DeMirci, H, Gelisio, L, Hajdu, J, Hunter, M S., Kurta, R P., Li , H, McFadden, M, Nazari, R, Schwander, Peter, Teslyuk, A, Walter, P, Xavier, P L., Yoon, C H., Zaare, S, Ilyin, V A., Kirian, R A., Hogue, B G., Aquila, A, and Vartanyants, I A.“An advanced workflow for single-particle imaging with the limited data at an X-ray free-electron laser” IUCrJ7.Pt 6 (2020): 1102-1113.
Dashti, Ali, Mashayekhi, Ghoncheh, Shekhar, Mrinal, Hail, Danya B., Salah, Salah, Schwander, Peter, des Georges, Amedee, Singharoy, Abhishek, Frank, Joachim, and Ourmazd, Abbas. “Retrieving functional pathways of biomolecules from single-particle snapshots” Nature Communications11. (2020).
Sobolov, Egor, Zolotarev, Serguey, Giewekemeyer, Klaus, Bielecki, Johan, Okomoto, Kenta, Reddy, Hemanth K., Andreasson, Jakob, Ayyer, Kartik, Barak, Imrich, Bari, Sadia, Barty, Anton, Bean, Richard, Bobkov, Sergey, Chapman, Henry N., Chojnowski, Grzegorz, Daurer, Benedikt J., Dörner, Katerina, Ekeberg, Tomas, Flückiger, Leonine, Galzitskaya, Oxana, Gelisio, Luca, Hauf, Steffen, Hogue, Brenda G., Horke, Daniel A., Hosseinizadeh, Ahmad, Illyin, Vyacheslav, Jung, Chulho, Kim, Chan, Kim, Yoonhee, Kirian, Richard A., Kirkwood, Henry, Kulyk, Olena, Letrun, Romain, Loh, Duane, Messerschmidt, Marc, Mühlig, Kerstin, Ourmazd, Abbas, Raab, Natascha, Rode, Andrei V., Rose, Max, Round, Adam, Sata, Takushi, Schubert, Robin, Schwander, Peter, Sellberg, Jonas A., Sikorski, Marcin, Silenzi, Alessandro, Song, Changyong, Spence, John C., Stern, Stephan, Sztuk-Dambietz, Jolanta, Teslyuk, Anthon, Timneanu, Nicusor, Trebbin, Martin, Utrecht, Charlotte, Weinhausen, Britta, Williams, Garth J., Xavier, P L., Xu, Chen, Vartanyants, Ivan, Lamzin, Victor S., Mancuso, Adrian, and Maia, Filipe R.“Megahertz single-particle imaging at the European XFEL” Communications Physics(2020).
Poudyal, Ishwor, Schmidt, Marius, and Schwander, Peter. “Single-Particle Imaging by X-Ray Free-Electron Lasers – How Many Snapshots are Needed?” Structural Dynamics7.2 (2020): 12.
Sh, Yingchen, Y., Tai, Xuecheng, DeMirci,, Hasan, Hosseinizadeh, Ahmad, Hogue, Brenda G., Ourmazd, Abbas, Schwander, Peter, Vartaniants, Ivan A., Yoon, Chun H., Aquila, Andrew, and Liu, Haiguang. “Evaluation of the Performance of Classification Algorithms for XFEL Single-Particle Imaging Data” IUCrJ(2019).
Gisriel, Chris, Coe, Jesse, Letrun, Romain, Yefanov, Oleksandr M., Luna-Chavez, Cesar, Stander, Natasha E., Lisova, Stella, Mariani, Valerio, Kuhn, Manuela, Aplin, Steve, Grant, Thomas D., Doerner, Katerina, Sato, Tokushi, Echelmeier, Austin, Villarreal, Jorvani C., Hunter, Mark S., Wiedorn, Max O., Knoska, Juraj, Mazalova, Victoria, Roy-Chowdhury, Shatabdi, Yang, Jay-How, Jones, Alex, Bean, Richard, Bielecki, Johan, Kim, Yoonhee, Mills, Grant, Weinhausen, Britta, Meza, Jose D., Al-Qudami, Nasser, Bajt, Sasa, Brehm, Gerrit, Botha, Sabine, Boukhelef, Djelloul, Brockhauser, Sandor, Bruce, Barry D., Coleman, Matthew A., Danilevski, Cyril, Discianno, Erin, Dobson, Zachary, Fangohr, Hans, Martin-Garcia, Jose M., Gevorkov, Yaroslav, Hauf, Steffen, Hosseinizadeh, Ahmad, Januschek, Friederike, Ketawala, Gihan K., Kupitz, Christopher, Maia, Luis, Manetti, Maurizio, Messerschmidt, Marc, Michelat, Thomas, Mondal, Jyotirmoy, Ourmazd, Abbas, Previtali, Gianpietro, Sarrou, Iosifina, Schoen, Silvan, Schwander, Peter, Shelby, Megan L., Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Turcato, Monica, White, Thomas A., Wrona, Krzysztof, Xu, Chen, Abdellatif, Mohamed H., Zook, James D., Spence, John C. H., , Chapman, Henry N., Barty, Anton, Kirian, Richard A., Frank, Matthias, Ros, Alexandra, Schmidt, Marius, Fromme, Raimund, Mancuso, Adrian P., Fromme, Petra, and Zatsepin, Nadia A.“Membrane protein megahertz crystallography at the European XFEL” NATURE COMMUNICATIONS10. (2019).
Pande, Kanupriya, Donatelli, Jeffrey J., Malmerberg, Erik, Foucar, Lutz, Poon, Billy K., Sutter, Markus, Botha, Sabine, Basu, Shibom, Doak, R. B., Dorner, Katerina, Epp, Sascha W., Englert, Lars, Fromme, Raimund, Hartmann, Elisabeth, Hartmann, Robert, Hauser, Guenter, Hattne, Johan, Hosseinizadeh, Ahmad, Kassemeyer, Stephan, Lomb, Lukas, Montero, Sebastian F. Carron, , Menzel, Andreas, Rolles, Daniel, Rudenko, Artem, Seibert, Marvin M., Sierra, Raymond G., Schwander, Peter, Ourmazd, Abbas, Fromme, Petra, Sauter, Nicholas K., Bogan, Michael, Bozek, John, Bostedt, Christoph, Schlichting, Ilme, Kerfeld, Cheryl A., and Zwart, Petrus H.“Free-electron laser data for multiple-particle fluctuation scattering analysis” SCIENTIFIC DATA5. (2018).
Olmos, Jr, J L., Pandey, S, Martin-Garcia, J M., Calvey, G, Katz, A, Knoska, J, Kupitz, C, Hunter, M S., Liang, M, Oberthuer, D, Yefanov, O, Wiedorn, M, Heyman, M, Holl, M, Pande, K, Barty, A, Miller, M D., Stern, S, Roy-Chowdhury, S, Coe, J, Nagaratnam, N, Zook, J, Verburgt, J, Norwood, T, Poudyal, I, Xu, D, Koglin, J, Seaberg, M H., Zhao, Y, Bajt, S, Grant, T, Mariani, V, Nelson, G, Subramanian, G, Bae, E, Fromme, R, Fung, R, Schwander, Peter, Frank, M, White, T A., Weierstall, U, Zatsepin, N, Spence, J, Fromme, P, Chapman, H N., Pollack, L, Tremblay, L, Ourmazd, Abbas, Phillips, Jr, G N., and Schmidt, Marius. “Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography” BMC biology16.1 (2018): 59.
Ahmad, Hosseinizadeh, Ghoncheh, Mashayekhi, Jeremy, Copperman, Schwander, Peter, Ali, Dashti, Russell, Fung, Marius, Schmidt, ., Brenda, Hogue, Andrew, Aquila, and Ourmazd, Abbas. “Conformational Landscape of a Virus by Single-particle X-ray Scattering” Nature Methods14.9 (2017): 877–881.
Hosseinizadeh, Achmad, Mashayekhi, Goncheh, Copperman, Jeremy, Schwander, Peter, Dashti, Ali, Sepehr, Reyhaneh, Fung, Russel, Schmidt, Marius, Yoon, Chuck, Hogue, Brenda, Williams, Garth J., Aquilla, Andy, and Ourmazd, Abbas. “Conformational Landscape of a Virus by Single-particle X-ray Scattering” Nature Methodsonline. (2017).
Kupitz, Christoper, Schwander, Peter, and .. “Structural enzymology using X-ray free electron lasers” Structural Dynamics4. Ed. Schwander, Peter. (2017): 044003.
Dashti, Ali, Hail, Danya B., Mashayekhi, Ghoncheh, Schwander, Peter, des Georges, Amadee, Frank, Joachim, and .. “Conformational Dynamics and Energy Landscapes of Ligand Binding in RyR1” bioRxiv(2017).
Reddy, Hemanth K., Yoon, Chun Hong, Aquila, Andrew, Awel, Salah, Ayyer, Kartik, Barty, Anton, Berntsen, Peter, Bielecki, Johan, Bobkov, Sergey, Bucher, Maximilian, Carini, Gabriella A., Carron, Sebastian, Chapman, Henry, Daurer, Benedikt, DeMirci, Hasan, Ekeberg, Tomas, Fromme, Petra, Hajdu, Janos, Hanke, Max F., Hart, Philip, Hogue, Brenda G., Hosseinizadeh, Ahmad, Kim, Yoonhee, Kirian, Richard A., Kurta, Ruslan P., Larsson, Daniel S., Loh, Duane N., Maia, Filipe R., Mancuso, Adrian P., Mühlig, Kerstin, Munke, Anna, Nam, Daewoong, Nettelblad, Carl, Ourmazd, Abbas, Rose, Max, Schwander, Peter, Seibert, Marvin, Sellberg, Jonas A., Song, Changyong, Spence, John C., Svenda, Martin, Van der Schot, Gijs, Vartanyants, Ivan A., Williams, Garth J., and Xavier, P. Lourdu. “Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source” Nature – Scientific DataScientific Data 4.Article number: 170079 (2017).
Munke, Anna, Andreasson, Jakob, Aquila, Andrew, Awel, Salah, Ayyer, Kartik, Barty, Anton, Bean, Richard J., Berntsen, Peter, Bielecki, Johan, Boutet, Sébastien, Bucher, Maximilian, Chapman, Henry N., Daurer, Benedikt J., DeMirci, Hasan, Elser, Veit, Fromme, Petra, Hajdu, Janos, Hantke, Max F., Higashiura, Akifumi, Hogue, Brenda G., Hosseinizadeh, Ahmad, Kim, Yoonhee, Kirian, Richard A., Reddy, Hemanth K., Lan, Ti-Yen, Larsson, Daniel S., Liu, Haiguang, Loh, Duane N., Maia, Filipe R., Mancuso, Adrian P., Mühlig, Kerstin, Nakagawa, Atsushi, Nam, Daewoong, Nelson, Garrett, Nettelblad, Carl, Okamoto, Kenta, Ourmazd, Abbas, Rose, Max, van der Schot, Gijs, Schwander, Peter, Seibert, Marvin M., Sellberg, Jonas A., Sierra, Raymond G., Song, Changyong, Svenda, Martin, Timneanu, Nicusor, Vartanyants, Ivan A., Westphal, Daniel, Wiedorn, Max O., Williams, Garth J., Xavier, Paulraj Lourdu, Yoon, Chun Hong, and Zook, James. “Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source” Nature – Scientific Data(2016).
Pande, Kanupriya, Hutchinson, Christopher D., Groenhof, Gerrit, Aquilla, Andy, Robinson, Joe S., Tenboer, Jason, Basu, Shibom, DePonte, Daniel D., Liang, Meng, White, Thomas, Zatsepin, Nadia A., Yefanov, Oleksandr, Morozov, Dimitry, Oberthuer, Dominik, Gati, Cornelius, Subramanian, Ganesh, James, Daniel, Zhao, Yun, Koralek, Jacob, Brayshaw, Jennifer, Kupitz, Christopher, Conrad, Chelsie, Roy-Showdhuri, Shatabdi, Coe, Jesse D., Metz, Markus, Xavier, Poulray L., Grant, Thomas E., Koglin, Jason E., Ketawala, Gihan, Fromme, Raimund, Srajer, Vukica, Henning, Robert, Spence, John C., Ourmazd, Abbas, Schwander, Peter, Weierstall, Uwe, Frank, Matthias, Fromme, Petra, Barty, Anton, Chapman, Henry N., Moffat, Keith , van Thor, Jasper J., and Schmidt, Marius. “Femtosecond Structural Dynamics Drives the Trans/Cis Isomerization in Photoactive Yellow Protein” Science352. (2016): 725-729.
Hosseinizadeh, Ahmad, Dashti, Ali, Schwander, Peter, Fung, Russell, and Ourmazd, Abbas. “Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges” STRUCTURAL DYNAMICS(2015).
Pande, Kanupriya, Schmidt, Marius, Schwander, Peter, and Saldin, Dilano. “Simulations on time-resolved structure determination of uncrystallized biomolecules in the presence of shot noise” STRUCTURAL DYNAMICS2. (2015).