Professor Schmidt is using physical methods to investigate biological molecules. He is concentrating mainly on static and time-resolved macromolecular crystallography to investigate the structure, dynamics and kinetics of proteins. Schmidt is also developing new, sophisticated software for the analysis of the time-resolved (4-dimensional) X-ray data. Results from crystallography are corroborated by (time or energy resolved) spectroscopic methods.
Marius Schmidt obtained his Dipl. in Biology in 1990 at Johannes-Gutenberg-University, Mainz (Germany). He received his Dr. rer. Nat. in 1996 at Technische Universität München, Garching (Germany), where later he became habilitated in Experimental Physics in 2004. In 2008 he obtained an habilitation in the French system in Theoretical, physical and analytical Chemistry.
From 1996 to 1998 Schmidt worked as a scientist for the Physics Department at Technische Universität München (Germany) and from 1998 to 2001 as a research associate for the Department of Biochemistry and Molecular Biology at the University of Chicago. From 2001 to 2007 he worked as a scientist and Privatdozent for the Physics Department at Technische Universität München (TUM), (Germany).
Schmidt has been at the University of Wisconsin-Milwaukee since 2007, where he holds the rank of Professor.
Ahmad, Hosseinizadeh, Ghoncheh, Mashayekhi, Jeremy, Copperman, Schwander, Peter, Ali, Dashti, Russell, Fung, Schmidt, Marius, Yoon, Brenda, Hogue, Andrew, Aquila, and Ourmazd, Abbas. “Conformational Landscape of a Virus by Single-particle X-ray Scattering.” Nature Methods.
Pande, Kanupriya, Hutchinson, Christopher D., Groenhof, Gerrit, Aquilla, Andy, Robinson, Joe S., Tenboer, Jason, Basu, Shibom, DePonte, Daniel D., Liang, Meng, White, Thomas, Zatsepin, Nadia A., Yefanov, Oleksandr, Morozov, Dimitry, Oberthuer, Dominik, Gati, Cornelius, Subramanian, Ganesh, James, Daniel, Zhao, Yun, Koralek, Jacob, Brayshaw, Jennifer, Kupitz, Christopher, Conrad, Chelsie, Roy-Showdhuri, Shatabdi, Coe, Jesse D., Metz, Markus, Xavier, Poulray L., Grant, Thomas E., Koglin, Jason E., Ketawala, Gihan, Fromme, Raimund, Srajer, Vukica, Henning, Robert, Spence, John C., Ourmazd, Abbas, Schwander, Peter, Weierstall, Uwe, Frank, Matthias, Fromme, Petra, Barty, Anton, Chapman, Henry N., Moffat, Keith, van Thor, Jasper J., and Schmidt, Marius. “Femtosecond Structural Dynamics Drives the Trans/Cis Isomerization in Photoactive Yellow Protein.” Science
352. (2016): 725-729.
Ayyer, K, Yefanov, O M., Oberthür, D, Roy-Chowdhury, S, Galli, L, Mariani, V, Basu, S, Coe, J, Conrad, C E., Fromme, R, Schaffer, A, Dörner, K, James, D, Kupitz, C, Metz, M, Nelson, G, Xavier, P L., Beyerlein, K R., Schmidt, Marius, Sarrou, I, Spence, J C., Weierstall, U, White, T A., Yang, J H., Zhao, Y, Liang, M, Aquila, A, Hunter, M S., Robinson, J S., Koglin, J E., Boutet, S, Fromme, P, Barty, A, and Chapman, H N. “Macromolecular diffractive imaging using imperfect crystals.” Nature
530.7589 (2016): 202-6.
Schmidt, Marius, Pande, Kanupriya, Basu, Shibom, and Tenboer, Jason. “Room Temperature Structures beyond 1.5 Å by Serial Femtosecond Crystallography.” Structural Dynamics 2.041708 (2015): 1-9.
Tenboer, Jason, Basu, Shibom, Zatsepin, Nadia, Pande, Kanupriya, Milathianaki, Despina, Frank, Matthias, Hunter, Mark, Boutet, Sebastien, Williams, Garth, Koglin, Jason E., Oberthuer, Dominik, Heymann, Michael, Kupitz, Chris, Conrad, Chelsie, Coe, Jesse, Roy-Chowdhury, Shatabti, Weierstall, Uwe, James, Dan, Wang, Dingjie, Grant, Tom, Barty, Anton, Yefanov, Oleksandr, Scales, Jennifer, Gati, Cornelius, Seuring, Carolin, Srajer, Vukica, Henning, Robert, Schwander, Peter, Fromme, Raimund, Ourmazd, Abbas, Moffat, Keith, Van Thor, Jasper J., Spence, John C., Fromme, Petra, Chapman, Henry, and Schmidt, Marius. “Time Resolved Serial Crystallography Captures High Resolution Intermediates of Photoactive Yellow Protein.” Science
Schmidt, Marius, Srajer, Vukica, Ihee, Harry, Henning, Robert, Purwar, Namrta, Tenboer, Jason, and Tripathi, Shailesh. “Protein Energy Landscape Determined by Five-Dimensional Crystallography.” Acta Crystallographica D
69. (2013): 2534-2542.
Jung, Y.O., Lee, H., Kim, J, Schmidt, Marius, Moffat, K., Srajer, V., and Ihee, H. “Volume-conserving trans-cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography.” Nature Chemistry
Youngblut, Matt, Judd, Evan, Srajer, Vukica, Sayyed, Bilal, Goelzer, Tyler, Elliot, Sean, Schmidt, Marius, and Pacheco, Andy. “Laue Structure of Shewanella oneidensis ccNIR.” Journal of Biological Inorganic Chemistry
17. (2012): 647-672.
Schmidt, Marius, Srajer, Vukica, Purwar, Namrta, and Tripathi, Shailesh. “The Kinetic Dose Limit in Room-Temperature Time-Resolved Laue Crystallography.” J. Synchrotron Rad. 19.2 (2012): 264-273.
Purwar, Namrta, McGarry, Jennifer, Kostera, Josh, Pacheco, Andy, and Schmidt, Marius. “Interaction of Nitric Oxide with Catalase: Structural, and Kinetic Analysis.” Biochemistry
50. (2011): 4491-4503.