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Valerică Raicu

Professor
 (414) 229-4969
 Physics Building 486

Website: https://pantherfile.uwm.edu/vraicu/www/Raicu/

Research

Professor Raicu’s main research interests are:

  • Spectral fluorescence imaging, Förster resonance energy transfer (FRET), and nonlinear optical microscopy for studying protein-protein interactions and protein complex structure and dynamics in vivo
  • Studies of the physical properties of heterogeneous systems, including biological cells and tissues, biomembranes, electrode/electrolyte interfaces, polymers, and colloidal systems
  • Dielectric and mechanical relaxation in biological and nonbiological systems
  • Nonlinear laser spectroscopy for probing reaction dynamics and mechanical and thermal relaxation in proteins

Biographical Sketch

Valerică Raicu obtained his Physics Diploma in 1991 and his Ph.D. in Biophysics in 1998, both from the University of Bucharest (Romania). During that time, he worked as a Research Scientist for the Institute of Physical Chemistry of Romanian Academy (1992-1996) and for Research & Design Institute for Rare and Radioactive Metals (1996-1998). The following three years he was a Research Instructor at the Department of Physiology at Kochi Medical School (Japan). In 2002, Raicu obtained a Postdoctoral Fellowship at the Departments of Chemistry and Physics and Charles H. Best Institute, University of Toronto.

Since 2004, Raicu has been at the University of Wisconsin-Milwaukee, where he holds the rank of Professor in the Department of Physics and Adjunct Professor at the Department of Biological Sciences. He currently serves as the Chair of the Physics Department. Professor Raicu has developed a Biophysics course for which he also wrote the book Integrated Molecular and Cellular Biophysics (Springer, 2008). His research has been supported by the National Science Foundation (Programs: Physics of Living Systems, Major Research Instrumentation, and Partnerships for Innovation), Bradley Foundation, UWM Research Foundation, Aurora Spectral Technologies, LLC, and UWM Research Growth Initiative.

Selected Publications

Biener, Gabriel, Stoneman, Michael R., Acbas, Gheorghe, Holz, Jessica D., Komarova, Luidmila, Orlova, Marianna, Kuchin, Sergei, and Raicu, Valerica. “Development and experimental testing of an optical micro-spectroscopic technique incorporating true line-scan excitation.” International Journal of Molecular Sciences, MDPI AG 15.1 (2014): 261-76.
Singh, Deo R., Mohammad, Mohammad M., Patowary, Suparna, Stoneman, Michael, Oliver, Julie A., Movileanu, Liviu, and Raicu, Valerica. “Determination of the quaternary structure of a bacterial ATP-binding cassette (ABC) transporter in living cells.” Integrative Biology, The Royal Society of Chemistry 5.2 (2013): 312-323.
Patowary, Suparna, Alvarez-Curto, Elisa, Xu, Tian-Rui, Holz, Jessica D., Oliver, Julie A., Milligan, Graeme, and Raicu, Valerica. “The Muscarinic M3 Acetylcholine receptor exists as two differently sized complexes at the plasma membrane.” Biochemical Journal (2013).
Mannan, M. Amin-ul, Shadrick, William R., Biener, Gabriel, Anshu, Ashish, Raicu, Valerica, Frick, David N., and Dey, Madhusudan. “An Ire1-Phk1 Chimera Reveals a Dispensable Role of Autokinase Activity in Endoplasmic Reticulum Stress Response.” J. Mol. Biol. 425. (2013): 2083-99.
Singh, Deo R., and Raicu, Valerica. “FRET spectrometry: a new tool for the determination of protein quaternary structure in living cells.” Biophysical Journal, Reed Elsevier 105.9 (2013): 1937-45.
Stoneman, Michael, Patowary, Suparna, Singh, Deo R., Westrick, L, Oliver, Jule, and Raicu, Valerica. “Quantifying the efficiency of various FRET constructs using OptiMiS.” BioTechniques, Informa BioSciences 52.3 (2012): 191-195.
Stoneman, Michael R., Singh, Deo R., and Raicu, Valerica. “In-vivo quantification of G protein coupled receptor interactions using spectrally-resolved two-photon microscopy.” Journal of Visualized Experiments, Journal of Visualized Experiments 47.e2247 (2011).
Pisterzi, Luca, Jansam, David, Georgiou, J, Woodside, Michael, T-C Chou, J, Angers, Stephane, Raicu, Valerica, and Wells, James. “Oligomeric size of the M2 muscarinic receptor in live cells as determined by quantitative fluorescence resonance energy transfer (FRET).” Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 285. (2010): 16723–16738.
Habibi, Mohammad, Klemer, David, and Raicu, Valerica. “Two-dimensional dielectric spectroscopy: Implementation and validation of a scanning open-ended coaxial probe.” Review of Scientific Instruments, AIP Publishing LLC 81. (2010): 075108.