Dr. Cook is a University Distinguished Professor having a research focus on medicinal and synthetic organic chemistry. A key NIH-funded program deals with the design and synthesis of GABAAergic benzodiazepine receptor modulator ligands for the treatment of anxiety disorders, schizophrenia, neuropathic pain, Alzheimer’s disease, as well as alcohol dependence. His group also develops novel anti-infective agents and efficient methods for their synthesis. The Cook group is actively involved is the total synthesis of indole alkaloids with biological activity. Several therapeutic compounds have been licensed commercially for preclinical and clinical development.