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Decoding ncRNAs: Pharmacological Targets of Modifieoligonucleotides in an Emerging Application of Gene Therapeutics for Anticancer Drug Development – Grant Fernstrum

March 27, 2015 @ 3:00 pm - 4:00 pm

DECODING NCRNAS: PHARMACOLOGICAL TARGETS OF MODIFIEOLIGONUCLEOTIDES IN AN EMERGING APPLICATION OF GENE THERAPEUTICS FOR ANTICANCER DRUG DEVELOPMENT
Advisor: Dr. Alexander Arnold

ABSTRACT

Despite the fact that only ~1.5% of the studied human genome exists as the protein-coding exons, the non-protein coding portion is the largest part of the transcribed genome and is of crucial functional importance1. Within the last decade the discovery that noncoding RNAs (ncRNAs) play an integral role in cellular gene expression and are key regulators in maintaining cellular homeostasis has resulted in a boom of research activity. Deficiencies within the ncRNA pathway have been linked to cancer and the onset of human diseases such as neurological, cardiovascular, and autoimmune disorders making ncRNAs ideal pharmacological targets. Complementary base pairing of chemically synthesized oligonucleotides and modified oligonucleotide analogues to specific targets on ncRNA have shown to be effective modulators of ncRNAs resulting in tumor suppression and attenuation of genetic disorders2.

References:

1. Non-coding RNAs in human disease. Nat. Rev. 12, 861-874 (2011)
2. J. Med. Chem. 57, 10220-10240 (2014)

Details

Date:
March 27, 2015
Time:
3:00 pm - 4:00 pm
Event Category: