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Christopher Quinn

Assistant Professor
 (414) 229-2602
 Lapham Hall N413

Education

  • Postdoctoral Fellow, Rutgers University, 2009
  • PhD, Yale University, 2001
  • BA, Rutgers University, 1996

Research Interests

Our lab is interested in the question of how neural circuits are formed during development. Failures in this process may underlie mental and neurological disorders such as Autism and Down Syndrome. In addition, it is widely believed that an understanding of the mechanisms that control neural circuit formation will lead to the development of therapies to promote regeneration after neural injury.

We are currently focusing on axon guidance, a key step in the formation of neural circuits. Axon guidance involves the navigation of axons through the developing nervous system to reach their synaptic targets. This process is mediated by the growth cone, a structure that sits at the tip of growing axons. The growth cone steers to its target by making a series of attractive and repulsive responses to extracellular guidance cues. Previous studies have been successful in identifying several axon guidance cues and receptors. However, much less is known about the intracellular machinery that enables the growth cone to sense and respond to directional information. An important, yet poorly understood, part of this response involves the establishment of asymmetry within the growth cone. To learn about how asymmetry is established, we are taking advantage of the powerful genetic analysis that is possible with the model organism C. elegans, and complementing this with biochemical and cell culture experiments.

We have identified MIG-10/lamellipodin as an intracellular scaffolding protein that is required for guidance and is asymmetrically localized within the neuron as it responds to extracellular guidance cues (See Figure 1). We have found that MIG-10 is asymmetrically recruited by an interaction with the Rac GTPase, a component of a highly conserved direction-sensing module (See Figure 2). We are currently taking advantage of these findings to build our understanding of how asymmetry is established within the growth cone.

Selected Publications

Xu, Yan, Taru, Hidenori, Jin, Yishi, and Quinn, Christopher C. “SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) function interdependently to promote axon guidance by regulating the MIG-2 GTPase.” PLoS Genetics 11.4 (2015): e1005185.
Xu, Yan, and Quinn, Christopher C. “MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.” PLoS Genetics 8.11 (2012): e1003054.
Xu, Yan, Ren, Xing-Cong, Quinn, Christopher C., and Wadsworth, William G. “Axon response to guidance cues is stimulated by acetylcholine in Caenorhabditis elegans.” Genetics, Genetics Society of America 189.3 (2011): 899-906.
Quinn, Christopher C., Pfeil, D. S., and Wadsworth, W. G. “CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.” Current Biology 18.11 (2008): 808-13.
Quinn, Christopher C., and Wadsworth, W. G. “Axon guidance: asymmetric signaling orients polarized outgrowth.” Trends in Cell Biology 18.12 (2008): 597-603.
Quinn, Christopher C., Pfeil, D. S., Chen, E., Stovall, E. L., Harden, M. V., Gavin, M. K., Forrester, W. C., Ryder, E. F., Soto, M. C., and Wadsworth, W. G. “UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin.” Current Biology 16.9 (2006): 845-53.
Quinn, Christopher C., and Wadsworth, W. G. “Axon guidance: ephrins at WRK on the midline.” Current Biology 16.22 (2006): R954-5.